As filed with the Securities and Exchange Commission on December 21, 2020

Registration No. 333-188368

Registration No. 333-106007

Registration No. 333-104828

Registration No. 333-96541

Registration No. 333-87736

Registration No. 333-67370

Registration No. 333-59380

Registration No. 333-39238

Registration No. 333-94367

Registration No. 333-86611

Registration No. 333-40681

Registration No. 333-38055

Registration No. 333-26979

Registration No. 333-00391

Registration No. 033-59009

Registration No. 033-57583

Registration No. 33-52252

Registration No. 33-40295

Registration No. 33-40294

Registration No. 33-32875

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-188368

POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-106007

POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-104828

POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-96541

POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-87736

POST-EFFECTIVE AMENDMENT NO. 2 TO FORM S-8 REGISTRATION STATEMENT NO. 333-67370

POST-EFFECTIVE AMENDMENT NO. 2 TO FORM S-8 REGISTRATION STATEMENT NO. 333-59380

POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-39238

POST-EFFECTIVE AMENDMENT NO. 2 TO FORM S-8 REGISTRATION STATEMENT NO. 333-93467

POST-EFFECTIVE AMENDMENT NO. 3 TO FORM S-8 REGISTRATION STATEMENT NO. 333-86611

POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-40681

POST-EFFECTIVE AMENDMENT NO. I TO FORM S-8 REGISTRATION STATEMENT NO. 333-38055

POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-26979

POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 333-00391

POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 033-59009

POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 033-57583

POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 33-52252

POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 33-40295

POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 33-40294

POST-EFFECTIVE AMENDMENT NO. 1 TO FORM S-8 REGISTRATION STATEMENT NO. 33-32875

UNDER THE SECURITIES ACT OF 1933

JOHNSON & JOHNSON

(Exact name of registrant as specified in its charter)

One Johnson & Johnson Plaza

New Brunswick, New Jersey 08933

(732) 524-0400

(Address of Principal Executive Offices)

JOHNSON & JOHNSON RETIREMENT SAVINGS PLAN

JOHNSON & JOHNSON SAVINGS PLAN FOR UNION REPRESENTED EMPLOYEES

JOHNSON & JOHNSON SAVINGS PLAN

JOHNSON & JOHNSON 2000 STOCK OPTION PLAN

SCIOS INC. 1992 EQUITY INCENTIVE PLAN

SCIOS INC. 1996 NON-OFFICER STOCK OPTION PLAN

JOHNSON & JOHNSON SAVINGS PLAN

ALZA CORPORATION TAX DEFERRAL INVESTMENT PLAN

SELFCARE, INC. EMPLOYEE STOCK PURCHASE PLAN

SELFCARE, INC. 1992 STOCK PLAN

SELFCARE, INC. 1994 INCENTIVE AND NONQUALIFIED STOCK OPTION PLAN

SELFCARE, INC. AMENDED AND RESTATED 1996 STOCK OPTION AND GRANT PLAN

STOCK OPTION GRANTS TO KEITH MAY, JEROME MCALEER AND DAVID SCOTT

INVERNESS MEDICAL TECHNOLOGY, INC. AMENDED AND RESTATED 2000 STOCK OPTION AND

GRANT PLAN INTEG INCORPORATED (FORMERLY INOMET, INC.) 1990 INCENTIVE AND STOCK

OPTION PLAN INTEG INCORPORATED (FORMERLY INOMET, INC.) 1991 INCENTIVE AND STOCK

OPTION PLAN INTEG INCORPORATED 1994 LONG-TERM INCENTIVE AND STOCK OPTION PLAN

INTEG INCORPORATED 1996 DIRECTORS’ STOCK OPTION PLAN

ALZA CORPORATION AMENDED AND RESTATED STOCK PLAN

ALZA CORPORATION AMENDED AND RESTATED EMPLOYEE STOCK PURCHASE PLAN

ALZA CORPORATION SUPPLEMENTAL EMPLOYEE STOCK PURCHASE PLAN

ALZA CORPORATION NONSTATUTORY STOCK OPTION PLAN

SEQUUS PHARMACEUTICALS, INC. 1987 EMPLOYEE STOCK OPTION PLAN

SEQUUS PHARMACEUTICALS, INC. 1987 CONSULTANT STOCK OPTION PLAN

SEQUUS PHARMACEUTICALS, INC. 1990 DIRECTOR STOCK PLAN

SEQUUS PHARMACEUTICALS, INC. EQUITY INCENTIVE PLAN

INNOVASIVE DEVICES, INC. 1992 STOCK OPTION PLAN

INNOVASIVE DEVICES, INC. 1996 NON-EMPLOYEE DIRECTOR STOCK PLAN

INNOVASIVE DEVICES, INC. 1996 OMNIBUS STOCK PLAN

CENTOCOR, INC. CONSULTANT NON-QUALIFIED STOCK OPTION AGREEMENTS

CENTOCOR, INC. 1983 INCENTIVE STOCK OPTION PLAN

CENTOCOR, INC. 1987 NON-QUALIFIED STOCK OPTION PLAN

CENTOCOR, INC. 1989 NON-EMPLOYEE DIRECTORS’ NON-QUALIFIED STOCK OPTION PLAN

GYNECARE, INC., 1994 STOCK PLAN

GYNECARE, INC. 1995 DIRECTOR OPTION PLAN

JOHNSON & JOHNSON/BIOSENSE (ISRAEL) LTD. 1995 STOCK OPTION PLAN

JOHNSON &JOHNSON/BIOSENSE, INC. 1996 STOCK OPTION PLAN

JOHNSON & JOHNSON STOCK OPTION PLAN FOR NON-EMPLOYEE DIRECTORS

THE CORDIS CORPORATION NON-QUALIFIED STOCK OPTION PLAN

THE CORDIS CORPORATION DIRECTOR NON-QUALIFIED STOCK OPTION PLAN

THE WEBSTER LABORATORIES, INC. 1992 STOCK PLAN

JOHNSON & JOHNSON 1995 STOCK OPTION PLAN

JOHNSON & JOHNSON 1991 STOCK OPTION PLAN

MITEK SURGICAL PRODUCTS, INC. 1988 STOCK OPTION PLAN

MITEK SURGICAL PRODUCTS, INC. NON-EMPLOYEE DIRECTOR STOCK OPTION PLAN

JOHNSON & JOHNSON 1991 STOCK OPTION PLAN

(Full title of the plan)

Matthew Orlando

Johnson & Johnson

Corporate Secretary

One Johnson & Johnson Plaza

New Brunswick, New Jersey 08933

(Name and address of agent for service)

Telephone: (732) 524-0400

(Telephone number, including area code, of agent for service)

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company” and “emerging growth company” in Rule 12b-2 of the Securities Exchange Act of 1934.

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.  ☐

EXPLANATORY NOTE

DEREGISTRATION OF SECURITIES

Johnson & Johnson (the “Registrant”) is filing these Post-Effective Amendments (“Amendments”) to those certain Registration Statements on Form S-8 (collectively, the “Registration Statements”) filed by Johnson & Johnson, a New Jersey corporation (“Johnson & Johnson”), as follows (note that the share numbers listed below do not take into account any corporate actions, such as stock splits, taken in the interim):

The offerings contemplated by the Registration Statements have been terminated. In accordance with the undertaking contained in the Registration Statements (pursuant to Item 512(a)(3) of Regulation S-K), Johnson & Johnson hereby removes from registration any securities that were registered but unsold under the Registration Statements. Accordingly, these Amendments are being filed to deregister any securities covered by the above referenced plans which remain unissued as of the date of this filing.

SIGNATURES

Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this Post-Effective Amendment to the Registration Statements to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of New Brunswick, State of New Jersey on this 21st day of December, 2020.

Pursuant to the requirements of the Securities Act of 1933, this Post-Effective Amendment to the Registration Statements on Form S-8 has been signed by the following persons in their respective capacities and on the respective dates indicated opposite their names.