TIDMPOLX
Polarean Imaging PLC
14 May 2021
Polarean Imaging plc
("Polarean" or the "Company")
Scientific presentations on hyperpolarised Xenon-129 at upcoming
medical conferences
Polarean's investigational drug/device combination product to be
prominently featured in presentations across a wide range of lung
diseases
Polarean Imaging plc (AIM: POLX), the medical - imaging
technology company, with an investigational drug - device
combination product to enhance magnetic resonance imaging (MRI) in
pulmonary medicine, announces a number of abstracts and oral
presentations highlighting the use of hyperpolarised Xenon-129
("(129) Xe") will be made by leading academic researchers at the
upcoming American Thoracic Society ("ATS 2021") virtual conference
from 14-19 May 2021 and the International Society for Magnetic
Resonance in Medicine ("ISMRM 2021") virtual conference from 15-20
May 2021.
23 abstracts related to the use of hyperpolarised (129) Xe were
accepted for presentation at ATS 2021, consisting of 8 oral
presentations and 15 e-poster presentations. Polarean is also
supporting ATS 2021 by hosting a virtual exhibit booth.
Additionally, 34 abstracts related to the use of hyperpolarised
(129) Xe were accepted for presentation at ISMRM 2021, consisting
of 7 oral presentations and 27 e-poster presentations.
Hyperpolarised (129) Xe will also be discussed in a symposium on 17
May and in a sunrise session on 18 May. Furthermore, Polarean is
supporting ISMRM 2021 by hosting a virtual exhibit booth.
Richard Hullihen, Chief Executive Officer of Polarean commented:
"We are pleased at the important work being done by leading
investigators in the field of functional lung imaging. The data
being presented at these key scientific meetings will further add
to the body of evidence on hyperpolarised (129) Xenon, highlighting
several areas of unmet needs in current diagnostic modalities.
Research of (129) Xe MRI in interstitial lung disease,
long-COVID-19, asthma, COPD and interventional pulmonology
procedures are among the presentations that will be showcased."
A subset of the abstracts that will be presented during the ATS
2021 and ISMRM conferences are listed below.
Lead Author and ATS Abstract Presentation Abstract ATS Notes
Title Date Number
Mummy D et al. 16-May 1052 ORAL PRESENTATION
Regional Changes in Ventilation Session A12: Sunday,
Following Bronchodilation May 16, 2021 (3:30-5pm)
in COPD Are Not Associated
with Improved Gas Exchange
on Xenon-129 MRI
------------- --------- -------------------------
Mcintosh M et al. 18-May 1111 ORAL PRESENTATION
Response to Benralizumab Session C4: Tuesday,
in Severe Asthma: Oscillometry May 18, 2021 (8-9:30am)
and MRI Ventilation Defect
Improvements in Participants
with Abnormal FeNO
------------- --------- -------------------------
Eddy RL et al. 18-May 1112 ORAL PRESENTATION
Structure-Function Imaging Session C4: Tuesday,
Phenotypes of Asthma Using May 18, 2021 (8-9:30am)
CT and 129Xe MRI
------------- --------- -------------------------
HE M et al. 18-May 1113 ORAL PRESENTATION
Probing Early-Stage Pulmonary Session C4: Tuesday,
Pathophysiology in Young May 18, 2021 (8-9:30am)
Healthy E-cigarettes Users
Using Hyperpolarized 129Xe
MRI
------------- --------- -------------------------
Bdaiwi, AS et al. 18-May 1114 ORAL PRESENTATION
In Vivo Lung Morphometry Session C4: Tuesday,
of Lymphangioleiomyomatosis May 18, 2021 (8-9:30am)
Using Hyperpolarized 129Xe
Diffusion MRI
------------- --------- -------------------------
Bier E et al. 18-May 1115 ORAL PRESENTATION
Hyperpolarized 129Xe Magnetic Session C4: Tuesday,
Resonance Oscillation Imaging May 18, 2021 (8-9:30am)
in Pulmonary Hypertension
------------- --------- -------------------------
Mummy D et al. 18-May 1116 ORAL PRESENTATION
Hyperpolarized 129Xe MRI Session C4: Tuesday,
Features Identify Functional May 18, 2021 (8-9:30am)
Differences That Do Not
Correlate with Chest CT
in Patients with Idiopathic
Pulmonary Fibrosis
------------- --------- -------------------------
Plummer JW et al. 18-May 1166 ORAL PRESENTATION
129Xe gas-exchange MRI Session C15: Tuesday,
to detect diffusion abnormalities May 18, 2021 (3:30-5pm)
in children following bone-marrow
transplantation
------------- --------- -------------------------
Ruppert K et al. May 14-19 1998
First Experience with Hyperpolarized
129Xe Imaging in a Recovered E-poster
COVID-19 Patient Session TP031
------------- --------- -------------------------
Ranota TK et al. May 14-19 3835 E-poster
The Use of Hyper-polarized Session TP92
129Xe Pulmonary MRI for
Study of the Lung Damage
in COVID-19 Survivors, Preliminary
Results
------------- --------- -------------------------
Matheson AM et al. May 14-19 4453 E-poster
This Is What COVID-19 Survival Session TP117
Looks Like: 129Xe MRI, Oscillometry
and Pulmonary Function Measurements
------------- --------- -------------------------
Kooner HK et al. May 14-19 4531 E-poster
CT Mucus Score Predicts Session TP120
Benralizumab Response in
Severe Asthma
------------- --------- -------------------------
Woodward E et al. May 14-19 4574 E-poster
Four Years Observation Session TP121
of the Emphysema Progression
in Alpha-1 Antitrypsin Deficiency
Using 3He/129Xe MRI
------------- --------- -------------------------
Hamedani H et al. May 14-19 4578 E-poster
Monitoring Patients with Session TP121
Endobronchial Valve Interventions
Using a Multifaceted Hyperpolarized
(HP) Xenon Lung Function
Assessment
------------- --------- -------------------------
Bier E et al. May 14-19 4589 E-poster
Within-session Repeatability Session TP122
of Pulmonary 129Xe Static
and Dynamic Spectroscopy
------------- --------- -------------------------
Amzajerdian F et al. May 14-19 4590 E-poster
Exploring the Use of Continuous Session TP122
RF Irradiation for Xenon
Polarization Transfer Contrast
Imaging
------------- --------- -------------------------
Lead Author and ISMRM Abstract Presentation Abstract ISMRM Notes
Title Date Number
Leewiwatwong S et al. 18-May 391 ORAL PRESENTATION
Deep learning-based thoracic (Session: Machine
cavity segmentation for Learning for Image
hyperpolarized 129Xe MRI Analysis)
------------- --------- ------------------------------
Mummy D et al. 19-May 589 ORAL PRESENTATION
Regional Changes in Ventilation (Session: Lung)
Following Bronchodilation
in COPD Are Not Associated
With Improved Gas Exchange
on Xenon-129 MRI
------------- --------- ------------------------------
Hahn A et al. 19-May 591 ORAL PRESENTATION
Response of Hyperpolarized (Session: Lung)
129Xe MRI measures of ventilation
and gas-exchange to anti-fibrotic
treatment in Idiopathic
Pulmonary Fibrosis
------------- --------- ------------------------------
Hamedani H et al. 19-May 592 ORAL PRESENTATION
Monitoring Patients with (Session: Lung)
Endobronchial Valve Interventions
Using a Multifaceted Hyperpolarized
Xenon Lung Function Assessment
------------- --------- ------------------------------
Marshall H et al. 20-May 680 ORAL PRESENTATION
Hyperpolarised xenon ventilation (Session: Latest
MRI in difficult asthma; Advances in Hyperpolarized
initial experience in a MRI)
clinical setting
------------- --------- ------------------------------
Bier E et al. 20-May 681 ORAL PRESENTATION
Extension of a Diagnostic (Session: Latest
Model for Pulmonary Hypertension Advances in Hyperpolarized
with Hyperpolarized 129Xe MRI)
Magnetic Resonance Imaging
and Spectroscopy
------------- --------- ------------------------------
Albert B J et al. 20-May 684 ORAL PRESENTATION
Preclinical Hyperpolarized (Session: Latest
129Xe Ventilation Imaging Advances in Hyperpolarized
Using 3D Spiral (FLORET) MRI)
Encoding
------------- --------- ------------------------------
Rao M. 17-May MEMBER-INITIATED
Imaging Beyond Perfusion SYMPOSIUM
Using 129Xe MRI (Imaging Beyond
Perfusion Using
129Xe MRI)
------------- --------- ------------------------------
Woodward E et al. 17-May 1269 E-poster
The Use of the 3He/129Xe (Session: Novel
MRI Lung Morphometry for Contrast Mechanisms)
a Longitudinal Observation
of the Emphysema Progression
in AATD Patients
------------- --------- ------------------------------
Grist J et al. 17-May 1736 E-poster
Utilizing hyperpolarised (Session: MRI in
xenon MRI to detect gas COVID-19)
transport deficiencies in
post-COVID lungs
------------- --------- ------------------------------
Ranota T et al. 17-May 1739 E-poster
Feasibility of Single Breath-hold (Session: Role
Isotropic Voxel 129Xe MRI of Advanced Imaging
in COVID-19 Survivors using in COVID-19)
a Key-Hole Method
------------- --------- ------------------------------
Collier G et al. 17-May 1746 E-poster
Imaging lung structure (Session: Role
and function in acute COVID-19 of Advanced Imaging
patients with 129Xe and in COVID-19)
1H MRI
------------- --------- ------------------------------
Wild J. 18-May SUNRISE SESSION
Hyperpolarized 129Xe MRI (Lung MRI: You
of the Lung Can Do It!)
------------- --------- ------------------------------
Lu T et al. 18-May 1968 E-poster
Convolutional Neural Networks (Session: Machine
for Super-resolution of Learning to Reconstruct
Hyperpolarized 129Xe MR Accelerated Scans)
Images of the Lung
------------- --------- ------------------------------
Gandhi D B et al. 18-May 2273 E-poster
Comparison of Respiratory-Gating (Session: Pediatrics:
Weighting Algorithms in Body Topics)
Neonatal Pulmonary UTE-MRI
------------- --------- ------------------------------
Chan H-F et al. 19-May 3214 E-poster
Comparison of UTE 1H lung (Session: Lung:
MRI with quantitative CT Disease Assessment)
and hyperpolarized 129Xe
diffusion-weighted MRI in
IPF
------------- --------- ------------------------------
Eaden J et al. 19-May 3216 E-poster
Correlation of global and (Session: Lung
regional hyperpolarised Disease Assessment)
129-Xenon MRI with quantitative
CT in patients with idiopathic
pulmonary fibrosis
------------- --------- ------------------------------
Bdaiwi A S et al. 20-May 3558 E-poster
Optimizing Acquisition (Session: Hyperpolarization:
and Analysis for Diffusion Gas)
Weighted Hyperpolarized
129Xe MRI of Pediatric and
Adult Lungs
------------- --------- ------------------------------
Astley J et al. 20-May 3560 E-poster
Comparison of 3D convolutional (Session: Hyperpolarization:
neural networks and loss Gas)
functions for ventilated
lung segmentation using
multi-nuclear hyperpolarized
gas MRI
------------- --------- ------------------------------
Schulte R et al. 20-May 3562 E-poster
Imaging Gas-Exchange Lung (Session: Hyperpolarization:
Function using Density-Weighted Gas)
MRSI and Hyperpolarised
129Xe Gas
------------- --------- ------------------------------
Pratt R et al. 20-May 3563 E-poster
A 129Xe/1H Switched Frequency (Session: Hyperpolarization:
High Pass Birdcage Coil Gas)
for Hyperpolarized 129Xe
Gas Lung Imaging in Neonates
at 1.5 T
------------- --------- ------------------------------
Norquay G et al. 20-May 3564 E-poster
Temporal correlation of (Session: Hyperpolarization:
alveolar-capillary 129Xe Gas)
signal dynamics with the
cardiac cycle
------------- --------- ------------------------------
Amzajerdian F et al. 20-May 3565 E-poster
Feasibility of Xenon Polarization (Session: Hyperpolarization:
Transfer Contrast Imaging Gas)
using Continuous RF Irradiation
------------- --------- ------------------------------
Hamedani H et al. 20-May 3566 E-poster
Reproducibility Study Measuring (Session: Hyperpolarization:
Ventilation, Gas Exchange Gas)
and Surface-to-Volume Using
Hyperpolarized Xenon in
Free-breathing Human Subjects
------------- --------- ------------------------------
Rao M et al. 20-May 3567 E-poster
3D isotropic spectroscopic (Session: Hyperpolarization:
imaging of hyperpolarized Gas)
129Xe in the human brain
------------- --------- ------------------------------
Chan H-F et al. 20-May 3568 E-poster
Background field inhomogeneity (Session: Hyperpolarization:
effects on hyperpolarized Gas)
129Xe diffusion-weighted
MRI at 1.5T and 3T
------------- --------- ------------------------------
Ruppert K et al. 20-May 3569 E-poster
Detection of pulmonary (Session: Hyperpolarization:
abnormalities in a rabbit Gas)
thoracic insufficiency syndrome
model using hyperpolarized
xenon-129 MRI
------------- --------- ------------------------------
Ball G et al. 20-May 3570 E-poster
Modelling realistic Rb (Session: Hyperpolarization:
density and temperature Gas)
distributions in a high
throughput xenon-129 polariser
------------- --------- ------------------------------
Lu J et al. 20-May 3571 E-poster
Template-based bias field (Session: Hyperpolarization:
correction of Hyperpolarized Gas)
129Xe Gas Ventilation MRI
------------- --------- ------------------------------
Bdaiwi A S et al. 20-May 3575 E-poster
2D and 3D Spiral for Diffusion (Session: Hyperpolarization:
Weighted MRI with Hyperpolarized Gas)
129Xe
------------- --------- ------------------------------
Driehuys B et al. 20-May 3791 E-poster
Establishing the Structurally (Session: Hyperpolarization:
Limited Healthy RBC to Barrier Gas & Non-Gas)
Ratio for 129Xe Gas Exchange
MRI
------------- --------- ------------------------------
Bier E et al. 20-May 3792 E-poster
Within-session Repeatability (Session: Hyperpolarization:
of Pulmonary 129Xe Static Gas & Non-Gas)
and Dynamic Spectroscopy
------------- --------- ------------------------------
Doganay O et al. 20-May 3793 E-poster
Assessment of Gas Exchange (Session: Hyperpolarization:
Parameters in Healthy and Gas & Non-Gas)
COPD Subjects using Hyperpolarized
Xenon-129 MRI and Alveolar
Gas-exchange Model
------------- --------- ------------------------------
Loza L et al. 20-May 3794 E-poster
A Comparison of Multi-breath (Session: Hyperpolarization:
Wash-in/Wash-out and RF-Contrast Gas & Non-Gas)
Hyperpolarized 129Xe Imaging
Schemes for Quantifying
Fractional Ventilation
------------- --------- ------------------------------
Costa M L et al. 20-May 3795 E-poster
Optimized Magnetization (Session: Hyperpolarization:
Decay Correction of Hyperpolarized Gas & Non-Gas)
Xe Ventilation Images Using
Radial-Keyhole
------------- --------- ------------------------------
Qian Y et al. 20-May 3796 E-poster
Simulating the impact of (Session: Hyperpolarization:
asymmetric geometries on Gas & Non-Gas)
apparent alveolar septal
wall thickness measurements
with hyperpolarized xenon-129
MRI
------------- --------- ------------------------------
Enquiries:
Polarean Imaging plc www.polarean.com / www.polarean-ir.com
Richard Hullihen, Chief Executive Via Walbrook PR
Officer
Jonathan Allis, Chairman
Stifel Nicolaus Europe Limited (NOMAD and
Sole Corporate Broker) +44 (0)20 7710 7600
Nicholas Moore / Ben Maddison / Samira Essebiyea (Healthcare
Investment Banking)
Nick Adams / Fred Walsh (Corporate
Broking)
Walbrook PR Tel: +44 (0)20 7933 8780 or polarean@walbrookpr.com
Paul McManus / Anna Dunphy Mob: +44 (0)7980 541 893 / +44
(0)7879 741 001
About Polarean ( www.polarean.com )
The Company and its wholly owned subsidiary, Polarean, Inc.
(together the "Group") are revenue-generating, investigational
drug-device combination companies operating in the high-resolution
medical imaging research space.
The Group develops equipment that enables existing MRI systems
to achieve an improved level of pulmonary function imaging and
specialises in the use of hyperpolarised Xenon gas ((129) Xe) as an
imaging agent to visualise ventilation. (129) Xe gas is currently
being studied for visualisation of gas exchange regionally in the
smallest airways of the lungs, across the alveolar tissue barrier,
and into the pulmonary bloodstream.
In October 2020, the Group submitted a New Drug Application
("NDA") to the FDA for hyperpolarised (129) Xe used to evaluate
pulmonary function and to visualise the lung using MRI. In December
2020, the Group received confirmation of acceptance of its NDA by
the FDA, with a target PDUFA action date of 5 October 2021.
The Group operates in an area of significant unmet medical need
and the Group's technology provides a novel investigational
diagnostic approach, offering a non-invasive and radiation-free
functional imaging platform. The annual burden of pulmonary disease
in the US is estimated to be over US$150 billion.
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