-- National Survey Shows Misconceptions Still Prevalent: Nearly One in Three Believe Tight Underwear Can Lead to Erectile Dysfunction NEW YORK, Sept. 20 /PRNewswire-FirstCall/ -- According to a recent survey of more than 4,000 men aged 40 - 60 living in the United States, men are surprisingly well informed about their health. While often given less credit than they deserve, men proved they are generally knowledgeable about things such as their health, including their current blood pressure and cholesterol level. Further, men shattered the myth that they refuse to enter a doctor's office: the survey found that of all respondents, 66 percent see a doctor once or more than once a year. These facts are just some of the findings of a new national survey conducted on behalf of Best Life magazine and Lilly ICOS LLC (NYSE:LLYNYSE:andNYSE:Nasdaq:NYSE:ICOS), the maker of Cialis(R) (tadalafil), in association with Dr. Ridwan Shabsigh of Columbia University Medical Center and New York Presbyterian Hospital/Columbia, by Harris Interactive(R). The survey was designed to gauge the attitudes, fears, and overall health knowledge of men in the United States. The survey, funded by Lilly ICOS, found that despite their relatively solid knowledge of general health, many men are still lacking important information about their sexual health. This may put their health at risk. "The popular belief is that men can rattle off sports scores and cite their stock portfolios, but they know very little about their health, so I was encouraged to learn that of all the men surveyed, 71 percent know their blood pressure numbers, and 66 percent know that the PSA is a test for prostate cancer," said Jeff Csatari, executive editor of Best Life magazine. While 73 percent of all men surveyed indicated that they are either "very comfortable" or "extremely comfortable" discussing important health issues with their physician, there are still some men that are hesitant to consult their doctor if they experience erectile problems. Twenty-five percent of all respondents are only "somewhat" or "not at all likely" to talk to their doctor about problems they may have with erectile function. Why? Of those men who are hesitant to see their doctor to discuss erectile dysfunction (ED), some incorrectly believe that ED "is just a sign of aging" (32 percent) or are simply too embarrassed (31 percent) to talk about it. What men should know is that ED can be caused by a number of conditions including diabetes, high blood pressure, and cardiovascular disease, any one of which merits medical attention. "I'm still amazed at what some men don't do -- specifically, go to their doctors when they experience symptoms that require attention. They still seem to be either embarrassed by certain health issues, or they think they're invincible," said Csatari. Let's Talk About Sex Experts agree that 80 - 90 percent of ED cases are related to a physical or medical condition, like diabetes, cardiovascular diseases, and prostate cancer treatment, while 10 - 20 percent of cases are due to psychological causes(1,2). Most men surveyed not only knew the definition of ED but also correctly identified its causes. However, there are some myths about erectile dysfunction that many respondents believe to be facts. Of all those surveyed, some believe that ED is caused by unsafe sexual behavior (38 percent), wearing tight underwear (29 percent), or even sleeping on one's stomach (4 percent). Men can rest easy, because these factors do not cause ED. "Based on what we know, some men wait an inordinate amount of time before they consult a doctor after experiencing ED. Generally men will wait three or four years before they seek medical help because they are just too embarrassed to talk about erectile problems," says Ridwan Shabsigh, M.D., associate professor of Urology at Columbia University Medical Center and the director of The New York Center for Human Sexuality at the New York Presbyterian Hospital/Columbia. "What men may not realize is that often ED hints at potentially life-threatening conditions -- erectile function can be viewed as an outward indicator of a man's overall health." Isn't it a Shame? The majority of those surveyed place a high priority on their ability to engage in sex. For example, comparing the loss of sexual ability to other losses, the survey found that if given the option, instead of losing the ability to have sex, men are significantly more likely to choose losing a full head of hair (87 percent vs. 13 percent of all respondents), having to declare bankruptcy (69 percent vs. 31 percent of all respondents), or losing their job (61 percent vs. 39 percent of all respondents). Some men remain reluctant to see their doctor, despite the availability of effective oral ED treatments and media attention to these treatments. "We've heard from thousands of men about the impact ED has on their relationships, and how much they regret the loss of intimacy due to their condition," said Leonard Blum, senior vice president, sales and marketing, ICOS Corporation. "We hope this survey will remind men of the close link between ED and their overall health. Also, it is important for men to know there are effective oral ED treatments such as Cialis available; men should see their doctor when they are experiencing symptoms." What To Do? A man with any concerns about his erectile function in particular or his health in general should see a doctor or other healthcare professional for either a brief consultation or a thorough physical exam, including diagnostic tests, depending on the man's medical history and the doctor's familiarity with that history. In addition to the negative impact that ED can have on a man's life, ED can also be an indication of an underlying medical condition such as diabetes, high blood pressure and/or cardiovascular disease. There is plenty a man can do to prepare for a doctor's visit, including being prepared to ask questions. For additional suggestions, see the October/November issue of Best Life on newsstands now, or visit http://www.bestlifeonline.com/ or http://www.cialis.com/. Survey Methodology This survey of 4,043 men aged 40 to 60, living in the United States, was conducted by Harris Interactive(R) on behalf of Lilly ICOS, the maker of Cialis, Best Life magazine, and in association with Dr. Ridwan Shabsigh of Columbia University Medical Center and New York Presbyterian Hospital/Columbia. The survey was fielded online from June 3, 2005 - June 17, 2005 across the U.S., specifically over-sampling participants in Atlanta, Chicago, Detroit, Dallas/Ft. Worth, Los Angeles, Miami, New York, Philadelphia, Seattle, and San Diego. Data were weighted to be representative of the total U.S. population of men aged 40 to 60 on the basis of age, gender, education, household income, race/ethnicity, and propensity to be online. Although online samples are not probability samples, in theory, with samples of this size, one can say with 95 percent certainty that the results have a sampling error of plus or minus 1.54 percentage points. Sampling error for the sub-sample of men who are not at all likely or somewhat likely to consult a doctor about erectile problems (n=901) is plus or minus 3.26 percentage points. About Cialis Cialis(R) (tadalafil) was approved by the FDA in November 2003 for the treatment of erectile dysfunction. Cialis is available by prescription only and is not for everyone. Men taking nitrates, often used for chest pain, should not take Cialis. Such a combination could cause a sudden, unsafe drop in blood pressure. The most common side effects with Cialis were headache, upset stomach, delayed backache or muscle ache. As with any ED tablet, in the rare event of priapism (an erection lasting more than four hours), men should seek immediate medical attention to avoid long-term injury. Men should not drink alcohol in excess with Cialis. Cialis does not protect a man or his partner from sexually transmitted diseases, including HIV. In rare instances, men taking prescription ED tablets (including Cialis) reported a sudden decrease or loss of vision. It's not possible to determine if these events are related directly to the ED tablets or to other factors. If a man has a sudden decrease or loss of vision, he should stop taking any ED tablet and seek immediate medical attention. Men should discuss their medical conditions and all medications with their doctors to ensure Cialis is right for them and that they are healthy enough for sexual activity. For full patient information, visit http://www.cialis.com/. About Lilly ICOS LLC Lilly ICOS LLC, a joint venture between ICOS Corporation (NASDAQ:ICOS) and Eli Lilly and Company (NYSE:LLY), developed tadalafil for the treatment of erectile dysfunction. ICOS Corporation, a biotechnology company headquartered in Bothell, Washington, is dedicated to bringing innovative therapeutics to patients. Through Lilly ICOS LLC, ICOS is marketing its first product, Cialis, for the treatment of erectile dysfunction. ICOS is working to develop treatments for serious unmet medical conditions such as pulmonary arterial hypertension, benign prostatic hyperplasia, cancer and inflammatory diseases. Additional information about ICOS is available at http://www.icos.com/. Lilly, a leading innovation-driven corporation is developing a growing portfolio of first-in-class and best-in-class pharmaceutical products by applying the latest research from its own worldwide laboratories and from collaborations with eminent scientific organizations. Headquartered in Indianapolis, Ind., Lilly provides answers -- through medicines and information -- for some of the world's most urgent medical needs. Additional information about Lilly is available at http://www.lilly.com/. About Best Life Best Life is the fastest growing men's magazine in the country(3). Published by Rodale, Inc., it offers hands-on advice about health, fitness, family, personal style and financial security for affluent, accomplished men. Through stunning photography, exceptional writing from noted authors and compelling service journalism, Best Life shows men how to spend their most precious resources -- time and money -- to live life to the fullest. The magazine will publish seven times through 2005 and 10 times in 2006. About Harris Interactive Harris Interactive Inc. (http://www.harrisinteractive.com/), the 13th largest market research firm in the world, is a Rochester, NY-based global research company that blends premier strategic consulting with innovative and efficient methods of investigation, analysis and application. Known for The Harris Poll(R) and for pioneering Internet-based research methods, Harris Interactive conducts proprietary and public research to help its clients achieve clear, material and enduring results. Harris Interactive combines its intellectual capital, databases and technology to advance market leadership through its U.S. offices and wholly owned subsidiaries, HI Europe in London (http://www.hieurope.com/), Novatris in Paris (http://www.novatris.com/), and through an independent global network of affiliate market research companies. Except for historical information contained herein, this press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements are based on current expectations, estimates and projections about the industry, management beliefs and certain assumptions made by the management of ICOS and Lilly. Investors are cautioned that matters subject to forward-looking statements involve risks and uncertainties, including economic, competitive, governmental, technological, legal and other factors discussed in the two companies' respective filings with the Securities and Exchange Commission, which may affect the business and prospects of the two companies and Lilly ICOS. Results and the timing and outcome of events may differ materially from those expressed or implied by the forward-looking statements in this press release. More specifically, there can be no assurance that Cialis will achieve commercial success or that competing products will not pre-empt market opportunities that might exist for the product. P-LLY (1) Diseases and Conditions: Impotence, http://www.umm.edu/men/impotenc.htm. Data accessed November 20, 2003 (2) Shabsigh, R. (2002). Back To Great Sex: Overcome ED and Reclaim Lost Intimacy. (New York: Kensington) 45-46 (3) Audit Bureau of Investigations, August 2005 Report. http://www.accessabc.com/ Date accessed: 09/07/2005. (Photo: http://www.newscom.com/cgi-bin/prnh/20031219/LLYLOGO http://www.newscom.com/cgi-bin/prnh/20050919/BESTLIFELOGO ) http://www.newscom.com/cgi-bin/prnh/20031219/LLYLOGO http://www.newscom.com/cgi-bin/prnh/20050919/BESTLIFELOGO DATASOURCE: Lilly ICOS LLC CONTACT: Kindra Strupp of Lilly, +1-317-277-5170; Lacy Fitzpatrick of ICOS, +1-425-415-2207; or Karen Mazzotta of Best Life, +1-631-549-1580

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