UPI Uroplasty Common Stock

 13G Page 2 of 7 Pages


 CUSIP No. 917277204
--------- --------------------------------------------------------------------------------------------------------

 1. NAMES OF REPORTING PERSONS
 I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

 PERCEPTIVE ADVISORS LLC

--------- --------------------------------------------------------------------------------------------------------

 2. CHECK THE APPROPRIATE BOX IF A GROUP* (a) [ ]
 (b) [ ]
--------- --------------------------------------------------------------------------------------------------------

 3. SEC USE ONLY



--------- --------------------------------------------------------------------------------------------------------

 4. CITIZENSHIP OR PLACE OF ORGANIZATION

 Delaware

------------------- ---- -------------------------------------------- --------------------------------------------
 NUMBER OF
 SHARES 5. SOLE VOTING POWER 0
------------------- ---- -------------------------------------------- --------------------------------------------
 BENEFICIALLY
 OWNED BY 6. SHARED VOTING POWER 865,248
------------------- ---- -------------------------------------------- --------------------------------------------
 EACH
 REPORTING 7. SOLE DISPOSITIVE POWER 0
------------------- ---- -------------------------------------------- --------------------------------------------
 PERSON WITH:
 8. SHARED DISPOSTIVE POWER 865,248
------------------- ---- -------------------------------------------- --------------------------------------------

 9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 865,248
--------- ------------------------------------------------------------------------- ------------------------------

 10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) [ ]
--------- --------------------------------------------------------------------------------------------------------

 11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 5.7%
--------- ------------------------------------------------------------------------- ------------------------------

 12. TYPE OF REPORTING PERSON (SEE INSTRUCTIONS) IA
--------- ------------------------------------------------------------------------- ------------------------------

--------------------------------------- ------------------------------------ -------------------------------------

 13G Page 3 of 7 Pages

CUSIP No. 917277204
--------------------------------------- ------------------------------------ -------------------------------------

 13. NAMES OF REPORTING PERSONS
 I.R.S. IDENTIFICATION NO. OF ABOVE PERSONS (ENTITIES ONLY)

 JOSEPH EDELMAN

--------- --------------------------------------------------------------------------------------------------------

 14. CHECK THE APPROPRIATE BOX IF A GROUP* (A) [ ]
 (B) [ ]
--------- --------------------------------------------------------------------------------------------------------

 15. SEC USE ONLY



--------- --------------------------------------------------------------------------------------------------------

 16. CITIZENSHIP OR PLACE OF ORGANIZATION

 United States of America

--------- --------------------------------------------------------------------------------------------------------
 NUMBER OF
 SHARES 17. SOLE VOTING POWER 0
------------------- ---- -------------------------------------------- --------------------------------------------
 BENEFICIALLY
 OWNED BY 18. SHARED VOTING POWER 865,248
------------------- ---- -------------------------------------------- --------------------------------------------
 EACH
 REPORTING 19. SOLE DISPOSITIVE POWER 0
------------------- ---- -------------------------------------------- --------------------------------------------
 PERSON WITH:
 20. SHARED DISPOSTIVE POWER 865,248
--------- ------------------------------------------------------------------------- ------------------------------

 21. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 865,248
--------- --------------------------------------------------------------------------------------------------------

 22. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) [ ]
--------- ------------------------------------------------------------------------- ------------------------------

 23. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9) 5.7%
--------- ------------------------------------------------------------------------- ------------------------------

 24. TYPE OF REPORTING PERSON (SEE INSTRUCTIONS) IN
--------- ------------------------------------------------------------------------- ------------------------------

 13G Page 4 of 7 Pages

CUSIP No. 917277204
--------------------------------------- ------------------------------------ --------------------------------------

ITEM 1.
 (a) Name of Issuer: Uroplasty, Inc.

 (b) Address of Issuer's Principal Executive Offices: 5420 Feltl Road
 Minnetonka, Minnesota 55413-2820

ITEM 2.

 This Schedule 13G (the "Schedule") is being filed with respect to
 shares of Common Stock (as defined below) of Uroplasty, Inc. (the
 (a) Name of Person Filing: "Issuer") which are beneficially owned by Perceptive Advisors LLC and
 Joseph Edelman (together, the "Reporting Persons"). See Item 4 below.


 Perceptive Advisors LLC
 (b) Address of Principal Business Office or, 499 Park Avenue, 25th Floor
 if none, Residence: New York, NY 10022

 (c) Citizenship: Perceptive Advisors LLC is a Delaware limited liability company and
 Joseph Edelman is a United States Citizen.

 (d) Title of Class of Common Stock, par value $.01 (the "Common Stock")
 Securities:

 (e) CUSIP Number: 917277204



 ITEM 3. IF THIS STATEMENT IS FILED PURSUANT TO SS.SS.240.13D-1(B) OR 240.13D-2(B) OR (C),
 CHECK WHETHER THE PERSON FILING IS A:

 (a) [ ] Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o).
 (b) [ ] Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c).
 (c) [ ] Insurance company as defined in section 3(a)(19) of the Act (15 U.S.C. 78c).
 (d) [ ] Investment company registered under section 8 of the Investment Company Act of 1940 (15
 U.S.C 80a-8).
 (e) [ ] An investment adviser in accordance with ss.240.13d-1(b)(1)(ii)(E);
 (f) [ ] An employee benefit plan or endowment fund in accordance with ss.240.13d-1(b)(1)(ii)(F);
 (g) [ ] A parent holding company or control person in accordance with ss. 240.13d-1(b)(1)(ii)(G);
 (h) [ ] A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12
 U.S.C. 1813);
 (i) [ ] A church plan that is excluded from the definition of an investment company under section
 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
 (j) [ ] Group, in accordance with ss.240.13d-1(b)(1)(ii)(J).

 13G Page 5 of 7 Pages

CUSIP No. 917277204
--------------------------------------- ------------------------------------ --------------------------------------

ITEM 4. OWNERSHIP.

 Provide the following information regarding the aggregate number and percentage of the class of
securities of the issuer identified in Item 1.

 The Reporting Persons beneficially own 865,248 shares of Common Stock
 held by a private investment fund to which Perceptive Advisors LLC
 (a) Amount beneficially owned: serves as the investment manager. Mr. Edelman is the managing member
 of Perceptive Advisors LLC.

 The beneficial ownership of 5.7% is based on the 15,310,040 outstanding
 (b) Percent of class: shares of Common Stock of the Issuer, as disclosed on the Issuer's Form
 10-K/A filed with the SEC on June 18, 2010.

 (c) Number of shares as to which the
 person has:

 (i) Sole power to vote or to direct the vote:
 0
 (ii) Shared power to vote or to direct the vote:
 865,248
 (iii) Sole power to dispose or to direct the disposition of: 0

 (iv) Shared power to dispose or to direct the disposition
 of: 865,248

ITEM 5. OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS

If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to
be the beneficial owner of more than five percent of the class of securities, check the following [ ].

--------------------------------------- ------------------------------------ -------------------------------------

 13G Page 6 of 7 Pages

CUSIP No. 917277204
--------------------------------------- ------------------------------------ -------------------------------------

ITEM 6. OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON


As referred to in Item 4, other persons have the right to receive and the power
to direct the receipt of dividends from, and the proceeds from the sale of,
certain of the shares reported herein. In that regard, Mr. Edelman is the
managing member of Perceptive Advisors LLC, the investment manager of a private
investment fund. Accordingly, the private investment fund has the right to
receive and the power to direct the receipt of, dividends and the proceeds from
the sale of the shares reported herein that are held through the private
investment fund.

ITEM 7. IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE
 SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY OR CONTROL PERSON.

Not applicable.


ITEM 8. IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP.

Not applicable.


ITEM 9. NOTICE OF DISSOLUTION OF GROUP.


Not applicable.

ITEM 10. CERTIFICATION

 The following certification shall be included if the statement is
 filed pursuant to ss.240.13d-1(b):

 By signing below I certify that, to the best of my knowledge and
 belief, the securities referred to above were acquired and are
(a) held in the ordinary course of business and were not acquired and are
 not held for the purpose of or with the effect of changing or
 influencing the control of the issuer of the securities and were not
 acquired and are not held in connection with or as a participant in
 any transaction having that purpose or effect. [X]

--------------------------------------- ------------------------------------ -------------------------------------

 13G Page 7 of 7 Pages

CUSIP No. 917277204
--------------------------------------- ------------------------------------ -------------------------------------

 SIGNATURE


 After reasonable inquiry and to the best of my knowledge and belief, I certify that the
information set forth in this statement is true, complete and correct.


--------------------------------------- ------------------------------------ -------------------------------------
June 23, 2010
Date

PERCEPTIVE ADVISORS LLC

/s/ Joseph Edelman
Signature

Joseph Edelman/Managing Member
Name/Title
June 23, 2010
Date

/s/ Joseph Edelman
Signature

Joseph Edelman
Name/Title

--------------------------------------- ------------------------------------ -------------------------------------

 The original statement shall be signed by each person on whose behalf
 the statement is filed or his authorized representative. If the
 statement is signed on behalf of a person by his authorized
 representative other than an executive officer or general partner of
 the filing person, evidence of the representative's authority to sign
 on behalf of such person shall be filed with the statement, provided,
 however, that a power of attorney for this purpose which is already on
 file with the Commission may be incorporated by reference. The name
 and any title of each person who signs the statement shall be typed or
 printed beneath his signature.

 NOTE: Schedules filed in paper format shall include a signed original
 and five copies of the schedule, including all exhibits. See
 ss.240.13d-7 for other parties for whom copies are to be sent.

 ATTENTION: INTENTIONAL MISSTATEMENTS OR OMISSIONS OF FACT CONSTITUTE
 FEDERAL CRIMINAL VIOLATIONS (SEE 18 U.S.C. 1001)