Waters Advances Proteomics and Lipidomics Research with Novel Mass Spectrometry Acquisition Mode
September 19 2016 - 11:02AM
Business Wire
Waters MS Technology Researchers Bob Bateman
and John Hoyes Recognized at HUPO World Congress with Science and
Technology Award
Waters Corporation (NYSE: WAT) introduces a new data acquisition
mode, SONAR™, for its Xevo® G2-XS quadrupole time-of-flight (QTof)
mass spectrometer (MS) that provides MS/MS data from
data-independent acquisitions (DIA). The technology enables
analytical scientists to be more efficient in the laboratory and
have more confidence in the results they generate. SONAR data
allows for the quantification and identification of lipids,
metabolites, and proteins in complex samples from a single
injection without additional method development normally associated
with MS/MS analysis.
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The novel MS acquisition mode was announced at the 15th annual
Human Proteome Organization (HUPO) World Congress, where Bob
Bateman and John Hoyes, senior MS technology experts at Waters
Corporation, are being recognized for advancing mass spectrometry
instrumentation.
In modern proteomics experiments, DIA-based mass spectrometry
has been a popular technique for capturing data-rich sample
profiles. As proteomics and lipidomics capabilities have
progressed, scientists seek to further focus experiments to
quantify specific peptides and proteins, which has required
additional method development and repeated assays. The newly
introduced SONAR data acquisition mode provides additional clarity
and information for increasingly complex samples.
“Today, as proteomics research has matured, scientists are
already collecting the majority of the information available from
proteins. What they want to be able to do is approach a protein or
specific peptides with a hypothesis, and use targeted MS/MS
quantification to investigate their ideas without setting up
additional methods or experiments,” said David Heywood, senior
manager, Omics business development at Waters Corporation. “Now,
with SONAR data acquisition, they can perform a more selective
all-in-one analysis. Compatible with high-speed UPLC separations,
it’s a more efficient workflow for more accurate qualitative and
quantitative analysis within a single injection.”
Waters Scientists Recognized at HUPO
Also at the annual HUPO meeting, Waters Corporation’s Consultant
for Technical Research, Bob Bateman, and MS Technical Director and
Scientific Fellow, John Hoyes, are being recognized for their
contributions to advancing technology for proteomics research with
the HUPO Industrial Advisory Board Science and Technology Award for
the development of the Q-Tof mass spectrometer.
“The availability of a Q-Tof tandem MS instrument had tremendous
influence on the development of proteomics in its early days, since
this type of mass spectrometer coupled with a nanoLC provided
unprecedented performance in analyzing a proteome,” noted the HUPO
Executive Committee in their award announcement. The Waters®
(Micromass®) Q-Tof™ Mass Spectrometer was first commercially
introduced in 1996 and has undergone many technological
advancements, most recently with the integration of ion mobility
separations and now with its novel SONAR MS data acquisition
mode.
SONAR Enhancements to MS Data Acquisition Modes
The additional selectivity offered by the SONAR data acquisition
mode is due to the behavior of the mass spectrometer’s quadrupole.
Instead of remaining open and transmitting all ions, in SONAR mode
the quadrupole slides over the selected mass range of interest,
with each scan capturing 200 spectra. The operation of the
quadrupole makes the SONAR mode compatible with fast
UltraPerformance LC® (UPLC®) separations that increase laboratory
throughput. Compounds that may have chromatographically coeluted
are now separated by the quadrupole and recorded individually for
more effective library searches. The SONAR data acquisition mode
collects both quantitative and qualitative data within a single
injection.
SONAR technology is the subject of several talks at HUPO World
Congress, taking place Sept. 18-22 at the Taipei International
Convention Center.
SONAR data is compatible with analytical workflows that utilize
Waters Progenesis® and Symphony™ software, and with third-party
software packages such as Skyline. SONAR is available on the Waters
Xevo G2-XS QTof Mass Spectrometer under MassLynx® Software
control.
Waters Corporation (NYSE:WAT) develops and manufactures advanced
analytical and material science technologies for laboratory
dependent organizations. For more than 50 years, the company has
pioneered a connected portfolio of separations science, laboratory
information management, mass spectrometry and thermal analysis
systems.
Waters, SONAR, Xevo, Micromass, Q-Tof, UltraPerformance LC,
UPLC, Progenesis, Symphony, and MassLynx are trademarks of Waters
Corporation.
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Waters CorporationKaren Haas, +1-508-482-3363Public
RelationsKaren_haas@waters.com
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