PLRX Pliant Therapeutics Inc

Pliant Therapeutics, Inc. (Nasdaq: PLRX), a clinical-stage biotechnology company and leader in the discovery and development of novel therapeutics for the treatment of fibrotic diseases, today announced that the Company will present four scientific posters at the upcoming 2024 American Thoracic Society (ATS) International Conference, taking place in San Diego, California from May 17-22, 2024.

The following abstracts are posted on ATS 2024’s online itinerary planner.

Title: Post-hoc Analysis of Biomarkers of Interstitial Lung Disease Progression in Participants with Idiopathic Pulmonary Fibrosis Receiving Bexotegrast Over 12-weeks in INTEGRIS-IPFPresenter: Martin L. Decaris, Ph.D., Senior Director, Translational Sciences, Pliant TherapeuticsPoster: 15055Session A68: Unveiling Novel Avenues in IPF TherapiesDate: Sunday, May 19, 2024Presentation Time: 11:30 a.m. – 1:15 p.m. Pacific TimeLocation: TDP15

Title: Bexotegrast Targets TGF-beta Inhibition to Specific Cell Types in the Fibrotic Human LungPresenter: Mahru C. An, Ph.D., Principal Scientist, Pliant TherapeuticsPoster: 11411Session B29: Biomarkers and New Therapeutics Targets in Lung FibrosisDate: Monday, May 20, 2024Presentation Time: 9:15 a.m. – 11:15 a.m. Pacific TimeLocation: San Diego Convention Center, Room 30C-E (Upper Level)

Title: Evaluation of Quantitative Imaging in a Phase 2a Study for the Treatment of Idiopathic Pulmonary Fibrosis with Bexotegrast (INTEGRIS-IPF)Presenter: Jonathan G. Goldin, M.D., Ph.D., Professor of Radiology, Medicine and Biomedical Physics at the David Geffen School of Medicine at the University of California, Los AngelesPoster: 10368Session C23: Machine Learned: AI-Driven Solutions in ILD and Lung TransplantDate: Tuesday, May 21, 2024Presentation Time: 9:15 a.m. – 11:15 a.m. Pacific TimeLocation: San Diego Convention Center, Room 33A-C (Upper Level)

Pliant was also selected for a featured oral presentation as part of the ATS 2024 Mini Symposiums program.

Title: Update on the Safety and Tolerability of Bexotegrast, A Dual-selective Inhibitor of Integrins αvβ6 and αvβ1, in Development for Idiopathic Pulmonary Fibrosis and Primary Sclerosing CholangitisPresenter: Gregory P. Cosgrove, M.D., FCCP, Vice President, Clinical Development, Pliant TherapeuticsOral Presentation: 10340Mini Symposium C95: New Clinical Trial Results in Chronic Lung DiseaseDate: Tuesday, May 21, 2024Presentation Time: 3:51 p.m. – 4:03 p.m. Pacific TimeLocation: San Diego Convention Center, Ballroom 20A (Upper Level)

Posters will be available to view during the ATS Conference, Sunday, May 19 - Wednesday, May 22.

About Pliant Therapeutics, Inc.

Pliant Therapeutics is a clinical-stage biopharmaceutical company and leader in the discovery and development of novel therapeutics for the treatment of fibrotic diseases. Pliant's lead product candidate, bexotegrast (PLN-74809), is an oral, small molecule, dual selective inhibitor of αvß6 and αvß1 integrins that is in development in the lead indications for the treatment of idiopathic pulmonary fibrosis, or IPF, and primary sclerosing cholangitis, or PSC. Bexotegrast has received Fast Track Designation and Orphan Drug Designation from the U.S. Food and Drug Administration (FDA) in IPF and PSC and Orphan Drug Designation from the European Medicines Agency in IPF and PSC. Pliant is conducting BEACON-IPF, a Phase 2b/3 trial of bexotegrast in IPF. Pliant has also developed PLN-1474, a small molecule, selective inhibitor of αvß1 integrin for the treatment of metabolic dysfunction-associated steatohepatitis, or MASH. Pliant has initiated a Phase 1 study for its third clinical program, PLN-101095, a small molecule, dual-selective inhibitor of αvß8 and αvß1 integrins, that is being developed for the treatment of solid tumors. In addition to clinical-stage programs, Pliant currently has a preclinical program targeting muscular dystrophies. For additional information, please visit: www.PliantRx.com. Follow us on social media: X, LinkedIn, Facebook and YouTube.

Investor and Media Contact:

Christopher KeenanVice President, Investor Relations and Corporate CommunicationsPliant Therapeutics, Inc.ir@pliantrx.com