ContraFect Corporation (Nasdaq:
CFRX), a late clinical-stage biotechnology company focused
on the discovery and development of direct lytic agents (DLAs),
including lysins and amurin peptides, as new medical modalities for
the treatment of life-threatening, antibiotic-resistant infections,
announces today that the Company has been selected to present two
posters at the ASM Microbe Conference to be held in Washington,
D.C. from June 9-13, 2022. The data being presented features the
Company’s Breakthrough Therapy designated product candidate,
exebacase, currently being studied in a pivotal Phase 3 superiority
design trial.
ASM Microbe 2022 Poster Presentation
Details:
Poster Title: |
Lysin Exebacase Has a Low Propensity for Resistance Development and
Suppresses the Emergence of Resistance to Anti-Staphylococcal
Antibiotics |
Session
Title: |
AAR02 Antibiotic Agents:
Mechanism of Action and Resistance |
Date: |
June 11, 2022, 10:00am―5:00pm
ET |
PresentationTimes: |
10:30am―11:30am ET and
4:00pm―5:00pm ET |
|
|
Poster
Title: |
Locally Delivered
Anti-staphylococcal Lysins Exebacase or CF-296 is Active in
Methicillin-Resistant Staphylococcus Aureus Implant-Associated
Osteomyelitis |
Session
Title: |
AAR06 Novel Approaches:
Diagnostics/Discovery and Non-Traditional Therapies to Combat
Drug-Resistant Infections |
Date: |
June 12, 2022, 10:00am – 5:00pm
ET |
PresentationTimes: |
10:30am―11:30am ET and
4:00pm―5:00pm ET |
|
|
Following the meeting, the presentation posters
will be available on the ContraFect website.
About Exebacase (CF-301):
Exebacase is a recombinantly-produced lysin
(cell wall hydrolase enzyme) with potent bactericidal activity
against Staph aureus, a major cause of bloodstream infections
(BSIs) also known as bacteremia. In the Company’s Phase 2 study of
exebacase, a pre-specified analysis of MRSA-infected patients
showed that the clinical responder rate at Day 14 in patients
treated with exebacase was nearly 43-percentage points higher than
in patients treated with SOC antibiotics alone (74.1% for patients
treated with exebacase compared to 31.3% for patients treated with
SOC antibiotics alone (p=0.010)). In addition to the higher rate of
clinical response, MRSA-infected patients treated with exebacase
showed a 21-percentage point reduction in 30-day all-cause
mortality (p=0.056), a four-day lower median length of hospital
stay and meaningful reductions in hospital readmission rates.
Exebacase was well-tolerated and treatment emergent adverse events,
including serious treatment-emergent serious adverse events (SAEs)
were balanced between the treatment groups. There were no SAEs
determined to be related to exebacase, there were no reports of
hypersensitivity related to exebacase and no patients discontinued
treatment with study drug in either treatment group.
Exebacase is currently being studied in the
Phase 3 DISRUPT superiority design study of exebacase in patients
with Staph aureus bacteremia, including right-sided
endocarditis.
Exebacase has the potential to be a
first-in-class treatment for Staph aureus bacteremia. The
lysin was licensed from The Rockefeller University and is being
developed at ContraFect.
About ContraFect
ContraFect is a biotechnology company focused on
the discovery and development of DLAs, including lysins and amurin
peptides, as new medical modalities for the treatment of
life-threatening, antibiotic-resistant infections. An estimated
700,000 deaths worldwide each year are attributed to
antimicrobial-resistant infections. We intend to address life
threatening infections using our therapeutic product candidates
from our platform of DLAs, which include lysins and amurin
peptides. Lysins are a new class of DLAs which are recombinantly
produced antimicrobial proteins with a novel mechanism of action
associated with the rapid killing of target bacteria, eradication
of biofilms and synergy with conventional antibiotics. Amurin
peptides are a novel class of DLAs which exhibit broad-spectrum
activity against a wide range of antibiotic-resistant Gram-negative
pathogens, including P. aeruginosa, Acinetobacter
baumannii, and Enterobacter species. We believe that the
properties of our lysins and amurin peptides will make them
suitable for targeting antibiotic-resistant organisms, such as MRSA
and highly resistant strains of P. aeruginosa, which can cause
serious infections such as bacteremia, pneumonia and osteomyelitis.
We have completed a Phase 2 clinical trial for the treatment
of Staph aureus bacteremia, including endocarditis, with
our lead lysin candidate, exebacase, which is the first lysin to
enter clinical studies in the U.S. Exebacase, currently being
studied in a pivotal Phase 3 clinical study, was granted
Breakthrough Therapy designation by the FDA for development as a
treatment of MRSA bloodstream infections, including right-sided
endocarditis, when used in addition to SOC anti-staphylococcal
antibiotics.
Follow ContraFect on
Twitter @ContraFectCorp and LinkedIn.
Activities related to exebacase during the
period of performance under the contract will be funded in part
with federal funds from HHS; ASPR; BARDA, under contract number
75A501212C00021.
Forward-Looking Statements
This press release contains, and our officers
and representatives may make from time to time, “This press release
contains, and our officers and representatives may make from time
to time, “forward-looking statements” within the meaning of the
U.S. federal securities laws. Forward-looking statements can be
identified by words such as “projects,” “may,” “will,” “could,”
“would,” “should,” “believes,” “expects,” “anticipates,”
“estimates,” “intends,” “plans,” “potential,” “promise” or similar
references to future periods. Examples of forward-looking
statements in this release include, without limitation, statements
regarding: the ASM Microbe presentations and data to be presented,
ContraFect’s ability to discover and develop DLAs as new medical
modalities for the treatment of life-threatening,
antibiotic-resistant infections, exebacase attributes, whether
ContraFect will address life-threatening infections using
therapeutic candidates from its DLA platform, whether exebacase has
the potential to be a first-in-class treatment for Staph aureus
bacteremia, whether lysins are a new class of DLAs which are
recombinantly produced, antimicrobial proteins with a novel
mechanism of action associated with the rapid killing of target
bacteria, eradication of biofilms and synergy with conventional
antibiotics, whether amurins are a novel class of DLAs which
exhibit broad-spectrum activity against a wide range of
antibiotic-resistant Gram-negative pathogens, and whether the
properties of ContraFect’s lysins and amurins will make them
suitable for targeting antibiotic-resistant organisms, such as MRSA
and P. aeruginosa. Forward-looking statements are statements
that are not historical facts, nor assurances of future
performance. Instead, they are based on ContraFect’s current
beliefs, expectations and assumptions regarding the future of its
business, future plans, strategies, projections, anticipated events
and trends, the economy and other future conditions. Because
forward-looking statements relate to the future, they are subject
to inherent risks, uncertainties and changes in circumstances that
are difficult to predict and many of which are beyond ContraFect’s
control, including the occurrence of any adverse events related to
the discovery, development and commercialization of ContraFect’s
product candidates such as unfavorable clinical trial results,
insufficient supplies of drug products, the lack of regulatory
approval, or the unsuccessful attainment or maintenance of patent
protection and other important risks detailed under the caption
“Risk Factors” in ContraFect's filings with the Securities and
Exchange Commission. Actual results may differ from those set forth
in the forward-looking statements. Important factors that could
cause actual results to differ include, among others, our ability
to develop treatments for drug-resistant infectious diseases. Any
forward-looking statement made by ContraFect in this press release
is based only on information currently available and speaks only as
of the date on which it is made. Except as required by applicable
law, ContraFect expressly disclaims any obligations to publicly
update any forward-looking statements, whether written or oral,
that may be made from time to time, whether as a result of new
information, future developments or otherwise.
Investor Relations Contacts:
Michael MessingerContraFect CorporationTel:
914-207-2300Email: mmessinger@contrafect.com
Media:
Jules AbrahamCORE IRTel:
917-885-7378Email: Julesa@coreir.com
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