By Clemens Bomsdorf and John D. Stoll 

COPENHAGEN--Flush with cash and holding a dominant position in the growing diabetes market, Novo Nordisk A/S has been on the lookout for potential takeover targets but sees little strategic reason to jump into the deal-making wave sweeping the global pharmaceuticals sector.

Instead, the Danish drug maker is turning its immediate attention to further beefing up its research and development staff. It announced this month a plan to expand its R&D staff in Denmark by 3,000 over the next eight years as part of a wider hiring plan aimed at increasing head count by 6,000, or 15%, by 2022 to keep pace with strengthening demand for insulin products.

Novo Nordisk Chief Operating Officer Kare Schultz said in an interview the company does have small licensing deals on the agenda, but it currently has no plans to abandon a 25-year strategy of avoiding megadeals.

"We have looked a lot [for possible takeover targets]," Mr. Schultz said. "Of course, we could merge with another company given our high value, but we do not see any strategic reason to do so."

The strategy comes during a bumper year for pharmaceutical deals. There have been 14 announced mergers and acquisitions valued at more than $1 billion in 2014, compared with 10 over the course of 2013, according to S&P Capital IQ.

Drugs giants have been signing deals to narrow their focus: in a series of asset swaps worth more than $25 billion, GlaxoSmithKline PLC sold its cancer drugs to Novartis AG in April, in return for acquiring vaccines and consumer health products. Merck & Co. sold its consumer health business to Bayer AG for $14.2 billion in May, and several players are looking to shed portfolios of older, off-patent medicines.

Meanwhile, a blockbuster $120 billion tie-up between Pfizer Inc. and AstraZeneca PLC was rejected by the latter's board last month. And major drugs companies remain willing to buy up smaller companies that could help them find new treatments.

For Novo Nordisk, staying the course has been supported by the company's board and its biggest owner, the Novo Nordisk Foundation (which exercises influence through the Novo A/S holding company), according to people familiar with the matter. Directors have consistently encouraged management to stay focused on a core strategy of dominating an insulin market fueled by higher diabetes rates in emerging markets.

About 80% of revenue comes from diabetes care products.

Under its current plan, Novo Nordisk returns positive cash flow to shareholders, paying high dividends and launching a string of share repurchases. The Novo Nordisk Foundation holds 74% of the voting rights and 25.5% of the share capital. The foundation could waive its controlling interest to pave the way for a merger if that deal was considered necessary to strengthen the company.

Novo Nordisk, with a market capitalizaton of 664 billion Danish kroner ($120 billion), is the largest company by market value in the Nordic region. Mr. Schultz said the company's organic growth rate, often hitting 10% annually, could be dented by an acquisition. He also suspects the company's dominant position may limit Novo Nordisk's ability to get proposed deals past antitrust regulators.

Created by a merger of two Danish companies in 1989, the company has in the years since not participated in a deal valued at $1 billion or more. The company currently has several licensing partnerships worldwide, many focused on research, and a handful of product partnerships.

"We don't see any significant synergies coming from going with a company in another area," Mr. Schultz said, referring to the plan to remain committed to partnerships and solo research in diabetes.

Novo Nordisk has relied on gains by its Victoza drug to help sustain sales following the rejection of a new insulin product, Tresiba, by U.S. regulators last year. The company has said it expects to potentially launch Tresiba in the critical U.S. market before rival products. A study presented at the American Diabetes Association meeting in San Francisco over the weekend showed Victoza given in a high doses helps weight loss, and the launch of Victoza as an obesity treatment is planned.

But pricing pressure in diabetes drugs has ramped up in the U.S., leading Novo to cut its 2014 sales guidance in May. Pharmacy benefit manager Express Scripts excluded Victoza and two Novo insulin products from its recommended prescribing list in January, meaning patients must pay full retail price for them.

Meanwhile, the diabetes field is also becoming more competitive, with rivals including GlaxoSmithKline, Eli Lilly and Company and AstraZeneca all lining up or launching new treatments.

Hester Plumridge contributed to this article.

Write to Clemens Bomsdorf at clemens.bomsdorf@wsj.com and John D. Stoll at john.stoll@wsj.com

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