LONDON, Feb. 19, 2018 /PRNewswire/ -- Download the full
report: https://www.reportbuyer.com/product/119494
The report provides separate comprehensive analytics for the US,
Canada, Japan, Europe, Asia-Pacific, and Rest of World.
Annual estimates and forecasts are provided for the period 2016
through 2024. Also, a five-year historic analysis is provided for
these markets. Market data and analytics are derived from primary
and secondary research. Company profiles are primarily based on
public domain information including company URLs.
The report profiles 14 companies including many key and niche
players such as:
- Allergan Plc
- Daewoong Pharmaceutical Co., Ltd.
- HUGEL Pharma
- Ipsen Group
- Medy-Tox Inc.
- Merz Pharma GmbH & Co. KGaA
Download the full report:
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BOTULINUM TOXIN MCP-1833 A GLOBAL STRATEGIC BUSINESS REPORT
CONTENTS
I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS
Study Reliability and Reporting Limitations
Disclaimers
Data Interpretation & Reporting Level
Quantitative Techniques & Analytics
Product Definitions and Scope of Study
Cosmetic Applications
Therapeutic Applications
II. EXECUTIVE SUMMARY
1. INDUSTRY OVERVIEW
Botulinum Toxin: Expanding Cosmetic & Therapeutic Applications
to Propel Growth
Therapeutic BTX Applications Lead, Cosmetic BTX Gradually Gaining
Momentum
Table 1: Global Therapeutic BTX Neurotoxin Market (2016):
Percentage Breakdown of Value Sales by Therapeutic Indication
(includes corresponding Graph/Chart)
Developed Regions Dominate Botulinum Toxin Market
Developing Markets to Drive Future Growth
Increase in Healthcare Spending Stirs Demand for BTX in Therapeutic
Applications
Table 2: Healthcare Spending as % of GDP by Geographic Region
(2016) (includes corresponding Graph/Chart)
Table 3: Per Capita Healthcare Spending (in $) in Select Developed
Countries for the Year 2016 (includes corresponding
Graph/Chart)
Cosmetic BTX - A Promising Application Market
Factors Propelling the Cosmetic BT Market - In a Nut Shell
Rise in the Number of Musculoskeletal Indications - Potential for
Growth
Pharma Companies Keenly Eye Lucrative BT Market
2. COMPETITIVE LANDSCAPE
Intense Competition Characterizes Botulinum Toxin Market
Allergan Leads the Global BTX Market
Table 4: Leading Products in the Global Aesthetic Botulinum Toxin
Market (2016): Percentage Breakdown of Value Sales for Botox,
Dysport, Dysport/Azzalure, Meditoxin, and Xeomin (includes
corresponding Graph/Chart)
Botulinum Toxin Products Worldwide
Botox - The Leading Brand in Cosmetic BTX Market
Biosimilar BTX Variants Challenge Botox's Leadership
Lack of Differentiation among Approved BTX Products
Comparison of Leading Neurotoxins - Botox, Dysport and Xeomin by
Safety and Efficacy
Daewoong Pharmaceutical All Set to Make a Mark on the International
Scenario
A Review of Major BTX Products
Comparison of Botox®, Dysport® and Xeomin® by Indications and Year
of Approval
BOTOX®
Approvals and Indications of Botox in Select Regions
Key Characteristics of Botox® and Botox® Cosmetic
Common Adverse Reactions with Botox
Therapeutics to Offer Higher Prospects for Botox
Botox Therapeutic Approvals in the US by Indication
Migraine Indication Bolsters Allergan's Botox Sales
Dysport®
Key Characteristics of Dysport®
Ipsen Counts on New Indications for Future Growth of Dysport
Dysport Therapeutic Development Pipeline by Region
Xeomin®
Key Characteristics of Xeomin®
Xeomin® FDA Approval and Indications
Global Expansion Helps Merz Gain in the BTX Market
Myobloc®/NeuroBloc®
Key Characteristics of Myobloc®
Meditoxin®
RT002
Other Products
3. MARKET TRENDS & ISSUES
Rising Demand for Non-Invasive Cosmetic Treatments Bodes Well for
BTX Market
Table 5: Non-Surgical Cosmetic Procedures Worldwide (2016):
Percentage Breakdown of Procedure Volume for Injectables (Botulinum
Toxin, Calcium Hydroxylapatite, Hyaluronic Acid and Poly-L-Lactic
Acid), Facial Rejuvenation and Others (includes corresponding
Graph/Chart)
Botulinum Toxin - The Preferred Solution in Facial Injectables
Market
Table 6: Global Dermal Fillers Market by Application (2017):
Percentage Breakdown of Value Sales for Face Lift Treatment, Facial
Line Correction Treatment, Lip Treatment and Others (includes
corresponding Graph/Chart)
Table 7: Cosmetic Botulinum Toxin Procedures Performed Worldwide
(2016): Percentage Breakdown of Procedure Volume by Gender
(includes corresponding Graph/Chart)
Table 8: Number of Cosmetic Botulinum Toxin Procedures (in '000s)
in Select Countries for the Year 2016 (includes corresponding
Graph/Chart)
Botox Gains Popularity among Millennials
Table 9: Cosmetic Botulinum Toxin Procedures Performed Worldwide
(2016): Percentage Breakdown of Procedure Volume by Age Group
(includes corresponding Graph/Chart)
Longer Life Expectancy and Rising Disposable Incomes Propel Sales
of Cosmetic BTX
Table 10: Life Expectancy at Birth in Years of People in Select
Countries (2017) (includes corresponding Graph/Chart)
Table 11: Life Expectancy at Birth (in Years) of Men and Women by
Region (2017) (includes corresponding Graph/Chart)
BTX - The Wonder Drug for Increasing Number of Non-Cosmetic
Uses
BoNT/X - The New Toxin with Potential Use in New Therapeutic
Areas
Topical Botulinum Toxin: Needle-Free Administration Imparts an Edge
over Injected Variants
Unmet Medical Needs Encourage Off-Label Use: A Cause for Concern or
Jubilation?
Urgent Need for Physician Education about Off-Label Usage
Campaigns Boost Patient Awareness
Digital Revolution to Impact Consumer Choices
Financing of Non-Reimbursed Healthcare: Need of the Hour
Combination Therapies: A Double Whammy Success
Botulinum Toxin - Potential Applications in Treatment of Dental
Diseases
Short-lived Aesthetic Effects: A Strong Business Case for Revision
Treatments
Novel Injection Systems for Highly Precise Dosage of Botulinum
Toxin
Undesirable Side Effects: A Challenge to Reckon With
Immunogenicity Undermines Patient Compliance
Reduction of Protein Load in BTX Products - The Probable Answer for
Immunogenicity
Antigenicity: A Problematic Issue in Drug Development
Stringent Regulations Delay Market Approvals & Put
Reimbursements in Limbo
Study Offers Support for Possible Remote Effects with Botulinum
Toxin
Higher Product Costs to Challenge Market Growth
Consumer Skepticism: The Biggest Challenge to Beat
Animal Cruelty - A Part & Parcel of Botox Testing
Botulinum Toxins - A Wonder Drug or Bio-terror Threat?
Fears of Terrorism & Biological Warfare Thwart International
Trade
4. PRODUCT OVERVIEW
Botulinum Toxin: A Poison That Cures
Structure & Mechanism of Action
Disadvantages
Classification of Botulinum Toxin
Botulinum Toxin Type A
Historical Timeline of Botulinum Toxin: 1885-2002
Botulinum Toxin Type B
Procedure
Anaesthesia
Injection Procedure
Applications of Botulinum Toxin
Cosmetic Applications
Glabellar Lines
Facial Wrinkles
Key Cosmetic Indications for Botulinum Toxin
Crow's Feet
Forehead Rhytids
Temporal Brow Lift
Lower Eyelid Rhytids
Downturned Lips
Pebbly Chin
Therapeutic Applications
Movement Disorders/Pain
Cervical Dystonia
Hemifacial Spasm
Blepharospasm
Strabismus
Site of Injection and Doses of Neurotoxins used in the Treatment of
Dystonias
Chronic Pain
Botox in Migraine Treatment
List of Countries where Botox has been Approved for Prophylaxis of
Headache in Adults Suffering from Chronic Migraine
Table 12: Modes of Injection of Onabotulinum ToxinA for Chronic
Migraine by Dose and Muscle Injected (includes corresponding
Graph/Chart)
Hyperhidrosis
Bladder Dysfunctions
Spasticity
Other Applications
Side Effects
5. PRODUCT INTRODUCTIONS/APPROVALS
Ipsen Gains FDA Approval for Dysport® in Treatment of Lower Limb
Spasticity Treatment in Adults
Medytox to Introduce Coretox Protein Free Botox Product
Allergan's BOTOX® Cosmetic Wins FDA Approval for Third
Indication
Ipsen Gains FDA Approval for Dysport® in Treatment of Pediatric
Lower Limb Spasticity
Merz Receives European Approval for Bocouture® Use in Treatment of
Upper Facial Lines
Merz Announces Availability of Xeomin® 200-unit Single-Dose Vial in
US
FDA Approves BOTOX® for Treatment of Adult Lower Limb
Spasticity
6. RECENT INDUSTRY ACTIVITY
Allergan's VISTABEL® Receives Positive Opinion for Severe Forehead
Lines Treatment in Adults
Merz and Teijin Partner to Commercialize Xeomin® in Japan
Ipsen Inks Promotion Agreement with Saol Therapeutics
Bain Capital Takes Over Hugel
Huons to Invest in New BTX Plant in Korea
Allergan Gains Marketing Approval for BOTOX Vista® in Japan
Allergan Takes Over Anterios
Daewoong Pharm Expands Sales of Nabota BTX Biosimilar to
Southeast Asia
Revance Acquires BTX-related IP from Botulinum Toxin Research
Associates
Revance Releases Phase 2 Trial Results of RT001 Topical Botulinum
Toxin Type A Drug Candidate
Ipsen Collaborates with EpiVax for Developed Next-Gen Botulinum
Toxins
Revance Begins Phase 3 Clinical Trial for Botulinum Toxin Type A
Topical Gel
Revance Commences Phase 2 Study for RT002 Botulinum Toxin Type
A
Revance Begins Phase 2 Trial for Botulinum toxin Type A Topical
Gel
Bloomage BioTechnology and Medytox to Establish JV in China
Ipsen Gains FDA's sBLA Approval for Dysport®
Actavis Bags FDA Approval for Expanding BOTOX® Label
Actavis Acquires Allergan
7. FOCUS ON SELECT PLAYERS
Allergan Plc (Ireland)
Daewoong Pharmaceutical Co., Ltd. (South
Korea)
HUGEL Pharma (South Korea)
Ipsen Group (France)
Medy-Tox Inc. (South Korea)
Merz Pharma GmbH & Co. KGaA (Germany)
Metabiologics, Inc. (USA)
Revance Therapeutics, Inc. (USA)
US WorldMeds (USA)
8. GLOBAL MARKET PERSPECTIVE
Table 13: World Recent Past, Current & Future Analysis for
Botulinum Toxin by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Rest of World Markets Independently
Analyzed by Annual Sales Figures in US$ Thousand for the Years 2016
through 2024 (includes corresponding Graph/Chart)
Table 14: World Historic Review for Botulinum Toxin by Geographic
Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Rest of World Markets Independently
Analyzed by Annual Sales Figures in US$ Thousand for the Years 2011
through 2015 (includes corresponding Graph/Chart)
Table 15: World 14-Year Perspective for Botulinum Toxin by
Geographic Region - Percentage Breakdown of Dollar Sales for US,
Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Rest of World Markets for the Years
2011, 2017 & 2024 (includes corresponding Graph/Chart)
Table 16: World Recent Past, Current & Future Analysis for
Botulinum Toxin in Cosmetic Applications by Geographic Region - US,
Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Rest of World Markets Independently
Analyzed by Annual Sales Figures in US$ Thousand for the Years 2016
through 2024 (includes corresponding Graph/Chart)
Table 17: World Historic Review for Botulinum Toxin in Cosmetic
Applications by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Rest of World Markets Independently
Analyzed by Annual Sales Figures in US$ Thousand for the Years 2011
through 2015 (includes corresponding Graph/Chart)
Table 18: World 14-Year Perspective for Botulinum Toxin in Cosmetic
Applications by Geographic Region - Percentage Breakdown of Dollar
Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Rest of World Markets for the Years
2011, 2017 & 2024 (includes corresponding Graph/Chart)
Table 19: World Recent Past, Current & Future Analysis for
Botulinum Toxin in Therapeutic Applications by Geographic Region -
US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Rest of World Markets Independently
Analyzed by Annual Sales Figures in US$ Thousand for the Years 2016
through 2024 (includes corresponding Graph/Chart)
Table 20: World Historic Review for Botulinum Toxin in Therapeutic
Applications by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Rest of World Markets Independently
Analyzed by Annual Sales Figures in US$ Thousand for the Years 2011
through 2015 (includes corresponding Graph/Chart)
Table 21: World 14-Year Perspective for Botulinum Toxin in
Therapeutic Applications by Geographic Region - Percentage
Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific (excluding Japan) and Rest of World Markets for the Years
2011, 2017 & 2024 (includes corresponding Graph/Chart)
III. MARKET
1. THE UNITED STATES
A.Market Analysis
Current and Future Analysis
Therapeutic BTX Market - New Entrants Slow in Gaining Market
Share
Approved Therapeutic Indications of Botulinum Toxin in the US by
Year of Approval
Neurogenic OAB - A Relatively Smaller Market Opportunity
Idiopathic OAB Bodes Healthy Prospects for Botox
Cosmetic BTX Market: Rapid Growth in Store
Table 22: Age-wise Distribution for Botulinum Toxin Procedures
Performed in the US for the Year 2016 (includes corresponding
Graph/Chart)
Table 23: Gender Distribution for Botulinum Toxin Procedures
Performed in the US (2016) (includes corresponding Graph/Chart)
Increasing Demand for Cosmetic Treatments Bodes Well for BTX
Market
Some Interesting Facts on Cosmetic Procedures
Table 24: Number of Surgical & Non-Surgical Cosmetic Procedures
('000s) in the US for the Years 1997, 2015 & 2016 (includes
corresponding Graph/Chart)
Table 25: Top 5 Surgical Cosmetic Procedures in the US - Ranked by
the Number of Procedures Performed (In '000s) for 2016 (includes
corresponding Graph/Chart)
Table 26: Top 5 Non-Surgical Cosmetic Procedures in the US - Ranked
by the Number of Procedures Performed ('000s) for 2016 (includes
corresponding Graph/Chart)
Table 27: Total Number of Cosmetic Procedures Performed by Category
in the US (2016) (includes corresponding Graph/Chart)
Table 28: Number of Botulinum Toxin Procedures Performed in the US
(1997, 2015 and 2016) (includes corresponding Graph/Chart)
Demand for Professional Help On Rise
Aging Baby Boomers Drive Aesthetic Business
Table 29: US Population by Age Group (2017): Percentage Breakdown
for 0-14, 15-24, 25-59 and 65+ Age Groups (includes corresponding
Graph/Chart)
Table 30: North American Aging Population by Age Group: 1975-2050
(includes corresponding Graph/Chart)
Expanding Physician Base Extends Impetus to Growth
Table 31: Average Physician/Surgeon Fees for Botulinum Toxin Per
Procedure in the US (2007- 2016) (includes corresponding
Graph/Chart)
Competitive Landscape
Allergan's Botox Leads Cosmetic BTX Market
Major BTX Products and Associated Fillers in the Cosmetic Botulinum
Toxin Market
Table 32: Leading Brands in the US Cosmetic Neurotoxin Treatment
Market (2016): Percentage Breakdown of Value Sales for Botox,
Dysport and Others (includes corresponding Graph/Chart)
Dysport Takes on Botox in the Therapeutic Space
Table 33: Leading Brands in the US Therapeutic Botulinum Toxin
Market (2016): Percentage Breakdown of Value Sales for Botox and
Dysport (includes corresponding Graph/Chart)
AAN Releases New Guidelines on BTX for Identified Disorders
Rise in Botulinum Toxin Lawsuits - A Concern for Physicians?
Product Launches/Approvals
Strategic Corporate Developments
Key Players
B.Market Analytics
Table 34: US Recent Past, Current & Future Analysis for
Botulinum Toxin by Application - Cosmetic and Therapeutic Markets
Independently Analyzed by Annual Sales Figures in US$ Thousand for
the Years 2016 through 2024 (includes corresponding
Graph/Chart)
Table 35: US Historic Review for Botulinum Toxin by Application -
Cosmetic and Therapeutic Markets Independently Analyzed by Annual
Sales Figures in US$ Thousand for the Years 2011 through 2015
(includes corresponding Graph/Chart)
Table 36: US 14-Year Perspective for Botulinum Toxin by Application
- Percentage Breakdown of Dollar Sales for Cosmetic and Therapeutic
Markets for the Years 2011, 2017 & 2024 (includes corresponding
Graph/Chart)
2. CANADA
Market Analysis
Table 37: Canadian Recent Past, Current & Future Analysis for
Botulinum Toxin by Application - Cosmetic and Therapeutic Markets
Independently Analyzed by Annual Sales Figures in US$ Thousand for
the Years 2016 through 2024 (includes corresponding
Graph/Chart)
Table 38: Canadian Historic Review for Botulinum Toxin by
Application - Cosmetic and Therapeutic Markets Independently
Analyzed by Annual Sales Figures in US$ Thousand for the Years 2011
through 2015 (includes corresponding Graph/Chart)
Table 39: Canadian 14-Year Perspective for Botulinum Toxin by
Application - Percentage Breakdown of Dollar Sales for Cosmetic and
Therapeutic Markets for the Years 2011, 2017 & 2024 (includes
corresponding Graph/Chart)
3. JAPAN
A.Market Analysis
Current and Future Analysis
Table 40: Non-Surgical Aesthetic Procedures in Japan (2016): Percentage Breakdown of Number
of Procedures by Procedure Type (includes corresponding
Graph/Chart)
Strategic Corporate Developments
B.Market Analytics
Table 41: Japanese Recent Past, Current & Future Analysis for
Botulinum Toxin by Application - Cosmetic and Therapeutic Markets
Independently Analyzed by Annual Sales Figures in US$ Thousand for
the Years 2016 through 2024 (includes corresponding
Graph/Chart)
Table 42: Japanese Historic Review for Botulinum Toxin by
Application - Cosmetic and Therapeutic Markets Independently
Analyzed by Annual Sales Figures in US$ Thousand for the Years 2011
through 2015 (includes corresponding Graph/Chart)
Table 43: Japanese 14-Year Perspective for Botulinum Toxin by
Application - Percentage Breakdown of Dollar Sales for Cosmetic and
Therapeutic Markets for the Years 2011, 2017 & 2024 (includes
corresponding Graph/Chart)
4. EUROPE
A.Market Analysis
Current and Future Analysis
BTX Cosmetic Market Positioned for Growth
Botox Approvals and Indications in Select European Countries
Table 44: Non-Surgical Aesthetic Procedures in Select European
Countries (2016): Percentage Breakdown of Number of Procedures by
Procedure Type (includes corresponding Graph/Chart)
Anti-Aging Treatment on the Rise among Young Mothers
Regulations for Botulinum Toxin Usage in the EU
The United Kingdom
Cosmetic Treatment Procedures in the UK
Snapshots
Russia
Mandates Registration of BTX Drugs
Strategic Corporate Developments
Key Players
B.Market Analytics
Table 45: European Recent Past, Current & Future Analysis for
Botulinum Toxin by Application - Cosmetic and Therapeutic Markets
Independently Analyzed by Annual Sales Figures in US$ Thousand for
the Years 2016 through 2024 (includes corresponding
Graph/Chart)
Table 46: European Historic Review for Botulinum Toxin by
Application - Cosmetic and Therapeutic Markets Independently
Analyzed by Annual Sales Figures in US$ Thousand for the Years 2011
through 2015 (includes corresponding Graph/Chart)
Table 47: European 14-Year Perspective for Botulinum Toxin by
Application - Percentage Breakdown of Dollar Sales for Cosmetic and
Therapeutic Markets for the Years 2011, 2017 & 2024 (includes
corresponding Graph/Chart)
5. ASIA-PACIFIC
A.Market Analysis
Current and Future Analysis
Botox Approvals and Indications in Select Asian Countries
A PEEK INTO SELECT MARKETS
Australia
Table 48: Non-Surgical Aesthetic Procedures in Australia (2016): Percentage Breakdown of
Number of Procedures by Procedure Type (includes corresponding
Graph/Chart)
China
Rising Demand for Cosmetic Treatments - Opportunity for BTX
Botulinum Toxin Injections Approved by China Food and Drug
Administration (CFDA)
India
Table 49: Non-Surgical Aesthetic Procedures in India (2016): Percentage Breakdown of Number
of Procedures by Procedure Type (includes corresponding
Graph/Chart)
South Korea
Botulinum Toxin Market - An Overview
Table 50: South Korean Botulinum Toxin Use by Application for the
Years 2005, 2010 and 2015 (includes corresponding Graph/Chart)
Strong Demand for Cosmetic Procedures - Potential for BTX
Market
Table 51: Working Women as % of Total Female Population for 2005,
2010, 2015 & 2016 (includes corresponding Graph/Chart)
Table 52: Aging Population in Korea (2015 & 2025): Percentage
Breakdown of Population by Age Group (includes corresponding
Graph/Chart)
Table 53: Foreign Patients Visiting Korea for Plastic Surgery &
Dermatology Procedures as a % of Total Visits of Foreign Patients
(includes corresponding Graph/Chart)
Meditoxin Dominates Domestic BTX Market
Table 54: Leading Players in the South Korean Botulinum Toxin
Market (2016): Percentage Breakdown of Sales for Daewoong Pharma,
Hugel, Medytox and Others (includes corresponding Graph/Chart)
List of Domestic Botox Products in Korea
Strategic Corporate Developments
Key Players
B.Market Analytics
Table 55: Asia-Pacific Recent Past, Current & Future Analysis
for Botulinum Toxin by Application - Cosmetic and Therapeutic
Markets Independently Analyzed by Annual Sales Figures in US$
Thousand for the Years 2016 through 2024 (includes corresponding
Graph/Chart)
Table 56: Asia-Pacific Historic Review for Botulinum Toxin by
Application - Cosmetic and Therapeutic Markets Independently
Analyzed by Annual Sales Figures in US$ Thousand for the Years 2011
through 2015 (includes corresponding Graph/Chart)
Table 57: Asia-Pacific 14-Year
Perspective for Botulinum Toxin by Application - Percentage
Breakdown of Dollar Sales for Cosmetic and Therapeutic Markets for
the Years 2011, 2017 & 2024 (includes corresponding
Graph/Chart)
6. REST OF WORLD
A.Market Analysis
Current and Future Analysis
Latin America: Facial Injectables
Market Set for Strong Growth
Table 58: Non-Surgical Aesthetic Procedures in Brazil (2016): Percentage Breakdown of Number
of Procedures by Procedure Type (includes corresponding
Graph/Chart)
Israel: Health Ministry Bans
Cosmetic Botox Treatment by Dentists
Botox Approvals and Indications in RoW
Botox Approvals and Indications in Select Latin American
Regions
Botox Approvals and Indications in Other Select Global Regions
B.Market Analytics
Table 59: Rest of World Recent Past, Current & Future Analysis
for Botulinum Toxin by Application - Cosmetic and Therapeutic
Markets Independently Analyzed by Annual Sales Figures in US$
Thousand for the Years 2016 through 2024 (includes corresponding
Graph/Chart)
Table 60: Rest of World Historic Review for Botulinum Toxin by
Application - Cosmetic and Therapeutic Markets Independently
Analyzed by Annual Sales Figures in US$ Thousand for the Years 2011
through 2015 (includes corresponding Graph/Chart)
Table 61: Rest of World 14-Year Perspective for Botulinum Toxin by
Application - Percentage Breakdown of Dollar Sales for Cosmetic and
Therapeutic Markets for the Years 2011, 2017 & 2024 (includes
corresponding Graph/Chart)
IV. COMPETITIVE LANDSCAPE
Total Companies Profiled: 14 (including Divisions/Subsidiaries -
17) The United States (5)
Japan (1) Europe (5) - France (1) - Germany (1) - The United Kingdom (1) - Rest of Europe (2) Asia-Pacific (Excluding Japan) (6)
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