U.K. drug maker Shire PLC (SHP.LN) Friday reported a 23% rise in fourth quarter profit, as strong sales of newer drugs offset a decline in sales of a big seller now losing ground to generic competition.

The company, the U.K.'s third biggest pharmaceutical company by market capitalization, said it expects to grow revenue again in 2010, when it is scheduled to launch six new drugs in the U.S., Europe and elsewhere.

The company reported a fourth quarter net profit of $174.3 million, compared to a profit of $141.3 million a year earlier. Revenue increased 17% to $893.3 million, helped by higher royalty income from sales of authorized generics of hyperactivity drug Adderall XR and a 36% rise in sales of core products including Vyvanse, also for hyperactivity, and rare disease medicines Elaprase and Replagal.

The company said U.S. regulators are scheduled to give their verdict on approval for velaglucerase alfa, a drug for Gaucher disease now known as Vpriv, at the end of February.

At 1214 GMT, Shire shares were 19 pence or 1.5% higher at 1,329 pence, outperforming a 0.2% lower FTSE 100 index.

-By Jason Douglas, Dow Jones Newswires; 44-20-7842-9272; jason.douglas@dowjones.com

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