FORM 4 [ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                       
1. Name and Address of Reporting Person * Roseborough Teresa Wynn 2. Issuer Name and Ticker or Trading Symbol HOME DEPOT, INC. [ HD ] 5. Relationship of Reporting Person(s) to Issuer (Check all applicable)_____ Director                    _____ 10% Owner
__X__ Officer (give title below)    _____ Other (specify below)
EVP, Gen. Counsel & Corp. Sec.
(Last)         (First)         (Middle)
2455 PACES FERRY RD		 3. Date of Earliest Transaction (MM/DD/YYYY)
11/17/2021
(Street)
ATLANTA, GA 30339
(City)       (State)       (Zip)
 4. If Amendment, Date Original Filed (MM/DD/YYYY)
 
 6. Individual or Joint/Group Filing (Check Applicable Line) _X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)		 2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8)		 4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)		 6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
$.05 Common Stock  11/17/2021    M    6785  A $130.22  26626.5075  D   
$.05 Common Stock  11/17/2021    M    12093  A $147.36  38719.5075  D   
$.05 Common Stock  11/17/2021    S    300  D $398.76 (1) 38419.5075  D   
$.05 Common Stock  11/17/2021    S    2065  D $398.13 (2) 36354.5075  D   
$.05 Common Stock  11/17/2021    S    3298  D $397.11 (3) 33056.5075  D   
$.05 Common Stock  11/17/2021    S    3433  D $395.98 (4) 29623.5075  D   
$.05 Common Stock  11/17/2021    S    2505  D $394.96 (5) 27118.5075  D   
$.05 Common Stock  11/17/2021    S    977  D $394.20 (6) 26141.5075  D   
$.05 Common Stock  11/17/2021    S    6300  D $392.87 (7) 19841.5075  D   
$.05 Common Stock                 60  I  By Spouse 

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3)		 2. Conversion or Exercise Price of Derivative Security 3. Trans. Date 3A. Deemed Execution Date, if any 4. Trans. Code
(Instr. 8)		 5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		 6. Date Exercisable and Expiration Date 7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4)		 8. Price of Derivative Security
(Instr. 5)		 9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Employee Stock Options  $130.22  11/17/2021    M        6785    (8) 3/22/2026  common stock  6785.0  $0  56373  D   
Stock Options  $147.36  11/17/2021    M        12093    (8) 3/21/2027  common stock  12093.0  $0  44280  D   

Explanation of Responses:
(1)  The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $398.70 to $398.79, inclusive. The reporting person undertakes to provide to the Company, any security holder of the Company, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.
(2)  The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $397.67 to $398.65, inclusive. The reporting person undertakes to provide to the Company, any security holder of the Company, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.
(3)  The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $396.66 to $397.58, inclusive. The reporting person undertakes to provide to the Company, any security holder of the Company, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.
(4)  The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $395.58 to $396.52, inclusive. The reporting person undertakes to provide to the Company, any security holder of the Company, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.
(5)  The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $394.53 to $395.50, inclusive. The reporting person undertakes to provide to the Company, any security holder of the Company, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.
(6)  The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $393.52 to $394.51, inclusive. The reporting person undertakes to provide to the Company, any security holder of the Company, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.
(7)  The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions at prices ranging from $392.50 to $393.39, inclusive. The reporting person undertakes to provide to the Company, any security holder of the Company, or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.
(8)  The stock options were issued under The Home Depot, Inc. Amended and Restated 2005 Omnibus Stock Incentive Plan and vest annually in 25% increments beginning on the second anniversary of the grant date.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director 10% Owner Officer Other
Roseborough Teresa Wynn
2455 PACES FERRY RD
ATLANTA, GA 30339

EVP, Gen. Counsel & Corp. Sec.

Signatures
/s/Stacy S. Ingram, Attorney-in-Fact 11/19/2021
**Signature of Reporting Person Date
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