FORM 4
[ X ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public
Utility Holding Company Act of 1935 or Section 30(f) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

HRUSOVSKY E KEVIN 		2. Issuer Name and Ticker or Trading Symbol

CALIPER LIFE SCIENCES INC [ CALP ] 		5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

__ X __ Director                      _____ 10% Owner
__ X __ Officer (give title below)      _____ Other (specify below)
President & CEO
(Last)          (First)          (Middle)

68 ELM STREET 		3. Date of Earliest Transaction (MM/DD/YYYY)

11/7/2011
(Street)

HOPKINTON, MA 01748
(City)        (State)        (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)

 
6. Individual or Joint/Group Filing (Check Applicable Line)

_ X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3) 		2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8) 		4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5) 		5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4) 		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock   11/7/2011     D    826725   D $10.5   (1) 0   D    

Table II - Derivative Securities Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3) 		2. Conversion or Exercise Price of Derivative Security 3. Trans. Date 3A. Deemed Execution Date, if any 4. Trans. Code
(Instr. 8) 		5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5) 		6. Date Exercisable and Expiration Date 7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4) 		8. Price of Derivative Security
(Instr. 5) 		9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Option (Right to Buy)   $5.46   11/7/2011     D         630471      (2) 7/13/2013   Common Stock   630471     (2) 0   D    
Option (Right to Buy)   $5.85   11/7/2011     D         61518      (3) 7/29/2014   Common Stock   61518     (3) 0   D    
Option (Right to Buy)   $6.25   11/7/2011     D         30540      (4) 8/16/2015   Common Stock   30540     (4) 0   D    
Option (Right to Buy)   $6.4   11/7/2011     D         112637      (5) 3/28/2016   Common Stock   112637     (5) 0   D    
Option (Right to Buy)   $5.69   11/7/2011     D         78995      (6) 4/4/2017   Common Stock   78995     (6) 0   D    
Option (Right to Buy)   $4.09   11/7/2011     D         192940      (7) 3/5/2018   Common Stock   192940     (7) 0   D    
Option (Right to Buy)   $1.3   11/7/2011     D         199992      (8) 3/2/2019   Common Stock   199992     (8) 0   D    
Option (Right to Buy)   $3.42   11/7/2011     D         62500      (9) 2/22/2020   Common Stock   62500     (9) 0   D    
Option (Right to Buy)   $6.57   11/7/2011     D         135000      (10) 2/22/2021   Common Stock   135000     (10) 0   D    
Restricted Stock Unit     (11) 11/7/2011     D         10000      (12)   (13) Common Stock   10000     (12) 0   D    
Restricted Stock Unit     (11) 11/7/2011     D         125000      (12)   (13) Common Stock   125000     (12) 0   D    
Restricted Stock Unir     (11) 11/7/2011     D         400000      (14)   (13) Common Stock   400000     (14) 0   D    
Restricted Stock Unit     (11) 11/7/2011     D         75000      (12)   (13) Common Stock   75000     (12) 0   D    
Restricted Stock Unit     (11) 11/7/2011     D         45000      (12)   (13) Common Stock   45000     (12) 0   D    

Explanation of Responses:
( 1)  Shares were disposed of pursuant to the terms of the merger agreement (the "Merger Agreement") between the Issuer, PerkinElmer, Inc. and PerkinElmer Hopkinton Co. in exchange for the right to receive $10.50 per share in cash.
( 2)  This option, which was fully vested on 07/14/2007, was cancelled pursuant to the Merger Agreement in exchange for a cash payment for each share underlying the option equal to $5.04 per share, representing the difference between the merger consideration of $10.50 per share and the exercise price of the option.
( 3)  This option, which was fully vested on 10/30/2007, was cancelled pursuant to the Merger Agreement in exchange for a cash payment for each share underlying the option equal to $4.65 per share, representing the difference between the merger consideration of $10.50 per share and the exercise price of the option.
( 4)  This option, which was fully vested on 11/27/2008, was cancelled pursuant to the Merger Agreement in exchange for a cash payment for each share underlying the option equal to $4.25 per share, representing the difference between the merger consideration of $10.50 per share and the exercise price of the option.
( 5)  This option, which was fully vested on 12/29/2009, was cancelled pursuant to the Merger Agreement in exchange for a cash payment for each share underlying the option equal to $4.10 per share, representing the difference between the merger consideration of $10.50 per share and the exercise price of the option.
( 6)  This option, which was fully vested on 10/04/2010, was cancelled pursuant to the Merger Agreement in exchange for a cash payment for each share underlying the option equal to $4.81 per share, representing the difference between the merger consideration of $10.50 per share and the exercise price of the option.
( 7)  This option, which provided for vesting as to 25% of the underlying shares on the first anniversary of the grant date and as to an additional 1/48 of the shares monthly thereafter until the fourth anniversary of the grant date, became fully vested and cancelled as of the effective time of the merger pursuant to the Merger Agreement in exchange for a cash payment for each share underlying the option equal to $6.41 per share, representing the difference between the merger consideration of $10.50 per share and the exercise price of the option.
( 8)  This option, which provided for vesting as to 25% of the underlying shares on the first anniversary of the grant date and as to an additional 1/48 of the shares monthly thereafter until the fourth anniversary of the grant date, became fully vested and cancelled as of the effective time of the merger pursuant to the Merger Agreement in exchange for a cash payment for each share underlying the option equal to $9.20 per share, representing the difference between the merger consideration of $10.50 per share and the exercise price of the option.
( 9)  This option, which provided for vesting as to 25% of the underlying shares on the first anniversary of the grant date and as to an additional 1/48 of the shares monthly thereafter until the fourth anniversary of the grant date, became fully vested and cancelled as of the effective time of the merger pursuant to the Merger Agreement in exchange for a cash payment for each share underlying the option equal to $7.08 per share, representing the difference between the merger consideration of $10.50 per share and the exercise price of the option.
( 10)  This option, which provided for vesting as to 25% of the underlying shares on the first anniversary of the grant date and as to an additional 1/48 of the shares monthly thereafter until the fourth anniversary of the grant date, became fully vested and cancelled as of the effective time of the merger pursuant to the Merger Agreement in exchange for a cash payment for each share underlying the option equal to $3.93 per share, representing the difference between the merger consideration of $10.50 per share and the exercise price of the option.
( 11)  Each restricted stock unit represents a contingent right to receive on share of Issuer common stock.
( 12)  These restricted stock units, which provided for vesting in four equal annual installments, became fully vested and cancelled as of the effective time of the merger pursuant to the Merger Agreement in exchange for a cash payment equal to $10.50 per restricted stock unit.
( 13)  These restricted stock units do not have an expiration date.
( 14)  These restricted stock units, which provided for a special 4 year cliff vesting, became fully vested and cancelled as of the effective time of the merger pursuant to the Merger Agreement in exchange for a cash payment equal to $10.50 per restricted stock unit.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director 10% Owner Officer Other
HRUSOVSKY E KEVIN
68 ELM STREET
HOPKINTON, MA 01748 		X
President & CEO

Signatures
/s/ Stephen E. Creager Attorney-In-Fact 11/7/2011
** Signature of Reporting Person Date


Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
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