RNS Number:4784P
British Biotech PLC
05 September 2003


                                  SCHEDULE 10

                   NOTIFICATION OF MAJOR INTERESTS IN SHARES


1. Name of company

British Biotech plc


2. Name of shareholder having a major interest

Amvescap plc


3. Please state whether notification indicates that it is in respect of holding
of the shareholder named in 2 above or in respect of a non-beneficial interest
or in the case of an individual holder if it is a holding of that person's
spouse or children under the age of 18

Notification indicates that it is in respect of a non-beneficial interest and is
made on behalf of subsidiary companies of Amvescap plc. By virtue of the
Companies Act Section 203 Amvescap is deemed to have the same interest in the
shares


4. Name of the registered holder(s) and, if more than one holder, the number of
shares held by each of them

Vidacos Nominees Ltd            24,875,049
HSBC Nominees Ltd                6,812,003
Chase Nominees Ltd               1,539,099
Bank of New York Nominees Ltd    1,535,021
Northern Trust Nominees Ltd      1,084,823
CM Investment Nominees Ltd           1,718


5. Number of shares / amount of stock acquired

n/a


6. Percentage of issued class

n/a


7. Number of shares / amount of stock disposed

n/a


8. Percentage of issued class

n/a


9. Class of security

Ordinary 5p shares


10. Date of transaction

n/a


11. Date company informed

5 September, 2003


12. Total holding following this notification

35,847,713


13. Total percentage holding of issued class following this notification

26.98 per cent


14. Any additional information

Change in notifiable holding is due to increase in issued share capital. 

Amvescap advises that this shareholding includes the following notifiable
holdings: 
INVESCO Perpetual International Equity Fund, which holds 6,186,693 shares (4.65
per cent) and; 
INVESCO Perpetual UK Growth Fund, which holds 7,592,071 shares (5.64 per cent); 
both of which are registered in the name of Vidacos Nominees Ltd.

15. Name of contact and telephone number for queries

Tony Weir + 44 1 865 781166


16. Name and signature of authorised company official responsible for making
this notification

Tony Weir, Finance Director


Date of notification

5 September, 2003


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for loss of business or loss of profits) arising in contract, tort or otherwise
from the use of or inability to use this document, or any material contained in
it, or from any action or decision taken as a result of using this document or
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