NEWARK, Calif., June 13, 2018 /PRNewswire/ -- Intabio, Inc.,
announced today that it has entered into a collaboration with
Bruker to accelerate integration of Intabio's Blaze™ solution with
Bruker's high resolution mass spectrometers (MS). Intabio's Blaze™
utilizes a proprietary microchip technology to separate,
quantitate, and seamlessly transfer intact biotherapeutic proteins
by electrospray into a mass spectrometer for molecular
identification. Bruker will provide support for Intabio's
development of the hardware and software to integrate the Blaze
instrument to a Bruker MS.
"We are thrilled to be working with Bruker on the MS interface
for our Blaze system. Bruker is an ideal first partner due to the
organization's strengths in innovative, high-performance mass
spectrometry solutions," said Lena
Wu, Ph.D., CEO and co-founder of Intabio. "Intabio's
instrument is designed to operate as a stand-alone for imaged cIEF
only, or it can interface with any MS for imaged cIEF-MS analysis.
By working directly with Bruker, we can optimize the integration
between Blaze and Bruker's MS to provide a more robust solution for
our customers."
Rohan Thakur, Ph.D., Executive
Vice President for Bruker added, "Bruker's MS ion source design
provides the customer with a unique 'ease of use' benefit
especially when it comes to coupling separation techniques such as
cIEF. It makes the interface coupling a 'point-and-shoot'
combination, allowing the user to focus on high quality data and
not spend time adjusting the interface itself. This benefit
serves to improve productivity of this powerful hyphenated
technique for protein characterization in
biopharma."
Intabio is developing the first system to seamlessly integrate
capillary isoelectric focusing (cIEF) and mass spec, two pillars of
analytical methods in biopharmaceutical development and
manufacturing. The Blaze solution includes a bench-top instrument,
microfluidic chip, reagent kit, and software. Blaze utilizes
lab-on-a-chip functionality to integrate (1) separation of protein
isoforms by cIEF, (2) real-time, whole-column imaging of protein
isoforms for detection and quantitation, and (3) MS sample
preparation and delivery of each separated isoform by electrospray
into an adjacent mass spectrometer to provide molecular identity.
Because the Blaze system can provide an analysis of product quality
in minutes and can process 100-fold more samples at a fraction of
the cost of more traditional processes, Blaze delivers improved
productivity, shortened analytical timelines, and reduced risk of
costly therapeutic development failures.
Intabio will launch an early access program for Biopharma
customers in late summer 2018 for the Blaze.
About Intabio
Intabio, Inc. is a Silicon Valley-based
company developing analytical solutions to transform biotherapeutic
development and manufacturing with products that provide early
product quality characterization and profound efficiency gains
across all stages of biopharmaceutical development and
manufacturing. Intabio's first product, the Blaze™ system, is a
microchip-based instrument system that will provide rapid detection
and identification of subtle protein modifications - modifications
that can undermine the stability and efficacy of biotherapeutic
drugs such as monoclonal antibodies and recombinant proteins. For
more information, please visit us at www.intabio.com.
CONTACT: info@intabio.com
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SOURCE Intabio, Inc.