Redx Pharma plc Preclinical efficacy data presented on RXC005
May 15 2017 - 2:00AM
RNS Non-Regulatory
TIDMREDX
Redx Pharma plc
15 May 2017
15 May 2017
AIM: REDX
Abstract #219
Poster #210
REDX PHARMA PLC
("Redx" or "the Company")
Preclinical data for reversible BTK inhibitor RXC005 presented
at the 17(th) International Workshop of Chronic Lymphocytic
Leukemia
Redx Pharma, the research and development company focused on
cancer, immunology and infection, announces that preclinical
efficacy data in mouse-models for its development candidate,
RXC005, a reversible BTK inhibitor, has been presented in a poster
session at the 17(th) International Workshop of Chronic Lymphocytic
Leukemia (iwCLL) biennial meeting in New York City, U.S. on 14 May,
2017.
The poster, entitled "RXC005, a Potent and Selective, Reversible
BTK Inhibitor Targeting both Wild-type and Mutant C481S BTK with
Potent Efficacy in ABC-DLBCL Xenograft Mouse Models", demonstrated
that RXC005 successfully inhibits wild-type BTK and C481S mutant
BTK, as well as B-Cell Receptor signalling in ABC-DLBCL cell lines
and importantly primary CLL cells.
RXC005 was also shown to be highly selective and exhibits
improved target specificity against other Tec and Src kinase family
members. RXC005 demonstrated significant efficacy in ABC-DLBCL
xenograft mouse models such as TMD8 and OCI-Ly10 cell lines.
The poster can be found on the Company's website
www.redxpharma.com
Dr Neil Murray, Chief Executive Officer of Redx Pharma,
commented: "We are delighted to have presented further potent
efficacy data for one of our lead development candidates, RXC005,
at the prestigious iwCLL event in front of our peers and
contemporaries."
Dr Richard Armer, Chief Scientific Officer of Redx Pharma,
commented: "The data presented is further validation of RXC005's
potential to target both wild-type and mutant BTK, an important
emerging resistance mechanism in patients with CLL progression
following ibrutinib treatment. With good target engagement
demonstrated in the PK/PD studies and efficacy in mouse-models, we
look forward to filing an IND/CTA in late 2017 to take RXC005 into
the clinic."
For further information, please contact:
Redx Pharma Plc
Neil Murray, Chief Executive Officer T: +44 1625
469 900
Karl Hård, Head of IR & Corporate T: +44 7491
Communications 651 406
Cantor Fitzgerald Europe (Nomad & Broker) T: +44 20
7894 7000
Phil Davies/ Michael Reynolds
WG Partners LLP (Joint Broker) T: +44 20
3705 9330
Claes Spång/ Chris Lee/ David
Wilson
Consilium Strategic Communications T: +44 20
3709 5700
Amber Fennell/ Matthew Neal/ Melissa
Gardiner
About Redx Pharma Plc
Company website: www.redxpharma.com
Redx is focused on the discovery and development of proprietary,
small molecule therapeutics to address areas of high, unmet medical
need, principally in cancer, immunology and infection providing a
pipeline of assets to larger and emerging companies. By improving
the characteristics of existing drug classes to create highly
differentiated, novel, best-in-class drugs, Redx has already
established a broad portfolio of proprietary drug programs.
This information is provided by RNS
The company news service from the London Stock Exchange
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