FORM 4
[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public
Utility Holding Company Act of 1935 or Section 30(f) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

MADDEN DAVID 		2. Issuer Name and Ticker or Trading Symbol

ADOLOR CORP [ ADLR ] 		5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

__ X __ Director                      _____ 10% Owner
_____ Officer (give title below)      _____ Other (specify below)
(Last)          (First)          (Middle)

ADOLOR CORP, 700 PENNSYLVANIA DRIVE 		3. Date of Earliest Transaction (MM/DD/YYYY)

12/6/2011
(Street)

EXTON, PA 19431
(City)        (State)        (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)

 
6. Individual or Joint/Group Filing (Check Applicable Line)

_ X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3) 		2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8) 		4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5) 		5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4) 		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Adolor Common Stock (ADLR)   12/8/2011     M    20000   A $3.73   781407   D    
Adolor Common Stock (ADLR)   12/8/2011     M    100000   A $3.72   881407   D    
Adolor Common Stock (ADLR)   12/8/2011     M    45000   A $1.77   926407   D    
Adolor Common Stock (ADLR)   12/8/2011     M    20000   A $2.20   946407   D    
Adolor Common Stock (ADLR)   12/8/2011     M    20000   A $1.60   966407   D    
Adolor Common Stock (ADLR)   12/8/2011     M    30000   A $1.39   996407   D    
Adolor Common Stock (ADLR)   12/8/2011     M    30000   A $1.50   1026407   D    
Adolor Common Stock (ADLR)   12/6/2011     P    61650   A $4.65   1088057   D    
Adolor Common Stock (ADLR)   12/6/2011     P    18425   A $4.66   1106482   D    
Adolor Common Stock (ADLR)   12/7/2011     U    741095   D $4.25   (1) 365387   D    
Adolor Common Stock (ADLR)   12/8/2011     U    365387   D $4.25   (1) 0   D    
Adolor Common Stock (ADLR)   12/7/2011     U    70000   D $4.25   (1) 0   I   By Madden 2002 Trust   (2)

Table II - Derivative Securities Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3) 		2. Conversion or Exercise Price of Derivative Security 3. Trans. Date 3A. Deemed Execution Date, if any 4. Trans. Code
(Instr. 8) 		5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5) 		6. Date Exercisable and Expiration Date 7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4) 		8. Price of Derivative Security
(Instr. 5) 		9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (right to buy)   $3.73   12/8/2011     M         20000      (3)   (3) Adolor Common Stock (ADLR)   20000   $ 0   0   D    
Stock Option (right to buy)   $3.72   12/8/2011     M         100000      (3)   (3) Adolor Common Stock (ADLR)   100000   $ 0   0   D    
Stock Option (right to buy)   $1.77   12/8/2011     M         45000      (3)   (3) Adolor Common Stock (ADLR)   45000   $ 0   0   D    
Stock Option (right to buy)   $2.20   12/8/2011     M         20000      (3)   (3) Adolor Common Stock (ADLR)   20000   $ 0   0   D    
Stock Option (right to buy)   $1.60   12/8/2011     M         20000      (3)   (3) Adolor Common Stock (ADLR)   20000   $ 0   0   D    
Stock Option (right to buy)   $1.39   12/8/2011     M         30000      (3)   (3) Adolor Common Stock (ADLR)   30000   $ 0   0   D    
Stock Option (right to buy)   $1.50   12/8/2011     M         30000      (3)   (3) Adolor Common Stock (ADLR)   30000   $ 0   0   D    

Explanation of Responses:
( 1)  Shares are tendered pursuant to the tender offer commenced with respect to the Issuer's shares (the "Offer") at a purchase price of $4.25 per share in cash, plus one non-transferable contingent payment right for each share, which shall represent the right to receive up to $4.50 in cash subject to the fulfillment of certain conditions and/or the attainment of certain milestones, upon the terms and subject to the conditions set forth in the Offer.
( 2)  These securities are held in a trust for the benefit of the reporting person's children. Philip R. Mills is the Trustee. The reporting person disclaims beneficial ownership of these securities, and the filing of this report is not an admission that the reporting person is the beneficial owner of these securities for purposes of Section 16 or for any other purpose.
( 3)  Transaction pertains to the vesting of unvested stock options and the issuance of shares of common stock underlying certain vested stock options, pursuant to the terms of the Agreement and Plan of Merger, dated as of October 24, 2011, by and among the Issuer, FRD Acquisition Corporation and Cubist Pharmaceuticals, Inc. and the related Offer.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director 10% Owner Officer Other
MADDEN DAVID
ADOLOR CORP
700 PENNSYLVANIA DRIVE
EXTON, PA 19431 		X



Signatures
/s/ John M. Limongelli, Attorney-in-fact for David M. Madden 12/8/2011
** Signature of Reporting Person Date


Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
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