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AC Immune SA

AC Immune SA (ACIU)

4.05
-0.04
(-0.98%)
Closed June 22 4:00PM
4.13
0.08
(1.98%)
After Hours: 7:59PM

Professional-Grade Tools, for Individual Investors.

Key stats and details

Current Price
4.05
Bid
3.86
Ask
4.30
Volume
692,275
4.01 Day's Range 4.125
1.90 52 Week Range 5.14
Market Cap
Previous Close
4.09
Open
4.06
Last Trade
2
@
4.04
Last Trade Time
Financial Volume
$ 2,830,583
VWAP
4.0888
Average Volume (3m)
917,699
Shares Outstanding
99,197,829
Dividend Yield
-
PE Ratio
-7.37
Earnings Per Share (EPS)
-0.55
Revenue
14.8M
Net Profit
-54.23M

About AC Immune SA

AC Immune SA is a clinical-stage biopharmaceutical company that focuses on neurodegenerative diseases. The company uses its proprietary technology platforms to discover, design, and develop novel proprietary small molecules, antibodies, and vaccines for prevention, diagnosis, and treatment of neurod... AC Immune SA is a clinical-stage biopharmaceutical company that focuses on neurodegenerative diseases. The company uses its proprietary technology platforms to discover, design, and develop novel proprietary small molecules, antibodies, and vaccines for prevention, diagnosis, and treatment of neurodegenerative diseases associated with protein misfolding. Show more

Sector
Pharmaceutical Preparations
Industry
Pharmaceutical Preparations
Headquarters
Lausanne, Che
Founded
1970
AC Immune SA is listed in the Pharmaceutical Preparations sector of the NASDAQ with ticker ACIU. The last closing price for AC Immune was $4.09. Over the last year, AC Immune shares have traded in a share price range of $ 1.90 to $ 5.14.

AC Immune currently has 99,197,829 shares outstanding. The market capitalization of AC Immune is $399.77 million. AC Immune has a price to earnings ratio (PE ratio) of -7.37.

ACIU Latest News

AC Immune Progress Update on Phase 2 Active Immunotherapy Clinical Pipeline for Alzheimer's and Parkinson diseases

AC Immune Progress Update on Phase 2 Active Immunotherapy Clinical Pipeline for Alzheimer's and Parkinson diseases ABATE Phase 1b/2 AD trial of ACI-24.060 completed enrollment of cohorts 1 and 2...

PeriodChangeChange %OpenHighLowAvg. Daily VolVWAP
1-0.54-11.76470588244.594.68642310974.13725127CS
40.4913.76404494383.564.97823.473580994.43970683CS
121.053534.97822.259176993.3762276CS
26-0.05-1.219512195124.15.142.255046123.41857689CS
52297.56097560982.055.141.95182063.37743483CS
156-3.9-49.05660377367.9512.611.684347025.35428153CS
260-1.71-29.68755.7614.891.684281996.16600965CS

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ACIU Discussion

View Posts
MiamiGent MiamiGent 4 weeks ago
ACIU Stii in. Closed at $3.87 today, up 9.32%.
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MiamiGent MiamiGent 1 month ago
ACIU sold all yesterday at 3.46.
Rebot @ 3.35
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MiamiGent MiamiGent 1 month ago
$ACIU Added substantially in P-M @3.40.
Why go looking for a runner when ya got one!
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MiamiGent MiamiGent 1 month ago
ACIU Slow and steady wins the race!

At 2:12 pm: $3.54 +.24.... +7.28%
$3.59 HOD
Prev Close 3.30

2.8M vol.
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MiamiGent MiamiGent 1 month ago
$ACIU Being traded as it heads up. Has a catalyst this Q. Decent hold.
Bullish
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MiamiGent MiamiGent 1 month ago
AICU AC Immune Reports First Quarter 2024 Financial Results and Provides a Corporate Update
6:05 AM ET May-13-2024
AC Immune Reports First Quarter 2024 Financial Results and Provides a Corporate Update

Landmark deal announced with Takeda for ACI-24.060 with $100 million upfront and total potential payments for option exercise and milestones of up to approximately $2.1 billion
ACI-24.060 ABATE Phase 2 trial on track to report Abeta-PET imaging results in Q2 2024, evaluating amyloid plaque reduction after 6 months of anti-Abeta active immunotherapy
ACI-7104.056 VacSYn Phase 2 trial of anti-a-syn active immunotherapy in Parkinson’s disease (PD) on track for safety and immunogenicity interim data in H2 2024
Three-year cash runway with CHF 104.8 million at quarter end, plus $100 million upfront from Takeda and the anticipated ACI-35.030-related CHF 25 million milestone
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MiamiGent MiamiGent 1 month ago
$AICU Quote
AS OF 5/13/2024 11:37AM ET

$3.3399
+$1.0299 (+44.584%)
Bid x Size
$3.33 x 26
Ask x Size
$3.34 x 4
Volume
23,125,900
90 Day Avg. Vol.
166,680
Open
$3.38
Previous Close 05/10/2024
$2.31
Day Range
Low$2.88
High$3.47
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MiamiGent MiamiGent 1 month ago
AICU Will go ...can't beat the news ... and accumulation underway:

Volume
21,425,253
90 Day Avg. Vol.
166,680

128 X's the 90 DAV!!
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MiamiGent MiamiGent 1 month ago
$AICU 120 X 90 DAV!!
Have faith

Volume
20,132,107
90 Day Avg. Vol.
166,680
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MiamiGent MiamiGent 1 month ago
$ACIU Here we go..
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MiamiGent MiamiGent 1 month ago
$AICU There are a few with high shts but we'll get legs
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MiamiGent MiamiGent 1 month ago
$ACIU has the best news this morning..
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MiamiGent MiamiGent 1 month ago
$ACIU In @ 3.23. Let's go!
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MiamiGent MiamiGent 1 month ago
See my post above. But..
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MiamiGent MiamiGent 1 month ago
Lacking float + sht but still...
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Monksdream Monksdream 1 month ago
News this morning
Will it grow legs after 9:30
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TheFinalCD TheFinalCD 12 months ago
congrat$$$$ ACIU
👍️ 1
weedtrader420 weedtrader420 12 months ago
What a day $$$$$$
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weedtrader420 weedtrader420 12 months ago
I’m surprise ACIU is not trading up 200% today
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weedtrader420 weedtrader420 12 months ago
WOOHOOOOOO WOOHOOOOOO awesome break out
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weedtrader420 weedtrader420 12 months ago
WOOHOOOOOO WOOHOOOOOO
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weedtrader420 weedtrader420 12 months ago
FDA fast track
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weedtrader420 weedtrader420 12 months ago
ACIU$
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TheFinalCD TheFinalCD 12 months ago
ACIOU AND SOMETIMES Y

https://finviz.com/quote.ashx?t=ACIU&ty=c&ta=1&p=d
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$ubmachine $ubmachine 1 year ago
ACIU @$2.15, huge collaboration with Eli Lilly & Genentech!

ROBUST PIPELINE Addressing Alzheimer’s, Parkinson’s and other neurodegenerative diseases

"Based on our SupraAntigen® and Morphomer® technology platforms, we are advancing one of the industry’s broadest and most diverse clinical-stage pipelines focused on neurodegenerative diseases.
We design first- and best-in-class therapeutic and diagnostic candidates to tackle established and novel disease targets enabling AC Immune’s comprehensive precision medicine approach."
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$ubmachine $ubmachine 1 year ago
That`s huge! SAP founder is major shareholder with 21% stake!

AC Immune Key Shareholders

About Dietmar Hopp

About Dietmar Hopps dievini Hopp BioTech holding
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$ubmachine $ubmachine 1 year ago
CEO Andrea Pfeifer about Alzheimer & Parkinson:
(from an interview with german weekly magazine "Die Bunte", may 2022 - through google translator)
We've finally made a breakthrough in Parkinson's

Q: How is the brain destroyed in Alzheimer's and Parkinson's?

A: All neurodegenerative diseases - whether Alzheimer's, Parkinson, ALS – have one thing in common: a different protein that previously has a normal function in the body,
begins for reasons we don't even know yet, to change its structure. It becomes pathological, forms clumps and kills the nerve cells in the brain.
We want to fight these proteins. But that is great for two reasons difficult: The therapies first have to go all the way to be brought to the brain. And then they are only allowed to attack the sick protein, not the healthy one.

Q: Where do you stand in Parkinson's research?

A: We've had a groundbreaking breakthrough this year.
We have developed an imaging method that early diagnosis of Parkinson's disease could. What has been known about Alzheimer's for 20 years was for Parkinson's not yet possible. We can now to the first take a look inside the brains of Parkinson's patients and make the pathological deposits visible. That is a incredibly important first step in diagnosis and treatment development of Parkinson's disease. It's a revolution from my point of view.

Q: Why?

A: This is the only way we can make early and precise diagnoses.
When the first symptoms of Alzheimer's appear, that's it destroys up to 70 percent of nerve cells. It already exists today a blood test with a probability of more than 90 percent ability to predict whether one will fall ill. I am convinced that at some point this will also be possible with Parkinson's will be. And I also firmly believe that against both Diseases it will eventually have vaccinations.
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ALERTS100%to10000%GAIN ALERTS100%to10000%GAIN 1 year ago
looking good
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$ubmachine $ubmachine 1 year ago
ACIU clinical stage programs
ACI-7104 and ACI-12589
Their ACI-7104 and ACI-12589 is on alpha-synuclein for Parkinsons desease

Novel targets programs:
Anti-a-syn antibody and Morphomer® a-syn aggregation inhibitor on alpha-synuclein for Parkinsons desease
$$$
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$ubmachine $ubmachine 1 year ago
Latest ACIU news:
AC Immune Awarded New Grants from MJFF and Target ALS Supporting Programs Targeting TDP-43
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$ubmachine $ubmachine 1 year ago
ACIU had the most number of Alpha Synuclein drugs under development in 2022!!!
Parkinsons desease gamechanger on todays MJFF breakthrough news!!!!!
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$ubmachine $ubmachine 1 year ago
Parkinson Breakthrough News for ACIU
MICHAEL J. FOX FOUNDATION ANNOUNCES SIGNIFICANT BREAKTHROUGH IN SEARCH FOR PARKINSON'S BIOMARKER

alpha-synuclein is key protein here - A number of companies are involved in the development of Alpha Synuclein drugs. One of this few is AC Immune SA (ACIU) -
AC Immune SA had the most number of Alpha Synuclein drugs under development in 2022!!!
Read here about Alpha Synuclein Pipeline Drugs Market

AC Immune SA (ACIU) is currently a Nasdaq-listed 181m company! This one should rocket now!
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tw0122 tw0122 2 years ago
This one running in sympathy to BIIB news from last night
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Pedro2004 Pedro2004 3 years ago
Went back to single territory within 1.5 hours of trading.
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make it happen make it happen 3 years ago
Back to singles today or tomorrow imho over $110,000,000 million NEGATIVE cash flow

$0.03 revenue per share with huge negative operating margins and returns

Profitability
Profit Margin 0.00%
Operating Margin (ttm) -3,592.01%

Management Effectiveness
Return on Assets (ttm) -19.15%
Return on Equity (ttm) -33.76%

Income Statement
Revenue (ttm) 2.07M
Revenue Per Share (ttm) 0.03
Gross Profit (ttm) -44.06M
EBITDA -72.49M
Net Income Avi to Common (ttm) -74.3M
Diluted EPS (ttm) -1.12

Cash Flow Statement
Operating Cash Flow (ttm) -68.32M
Levered Free Cash Flow (ttm) -42.91M
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tw0122 tw0122 3 years ago
AC Immune’s Alzheimer’s Vaccine Generates Potent Anti-pTau Antibody Response in a Phase 1b/2a Study

Interim results of ACI-35.030 vaccination show high titers of antigen-specific antibodies at potentially therapeutic levels in 100% of older patients with early Alzheimer’s disease

ACI-35.030 was safe and well tolerated with no safety concerns observed. Results support plans to further develop the Alzheimer’s vaccine into Phase 2/3

LAUSANNE, Switzerland, Feb. 11, 2021 (GLOBE NEWSWIRE) -- AC Immune SA (NASDAQ: ACIU), a Swiss-based, clinical-stage biopharmaceutical company with a broad pipeline focused on neurodegenerative diseases, today announced positive interim results from its ongoing Phase 1b/2a clinical trial evaluating its first-in-class anti-phospho-Tau (pTau) vaccine candidate ACI-35.030 for the treatment of Alzheimer’s disease (AD). ACI-35.030 vaccination generated a potent antigen-specific antibody response against pTau in 100% of older patients with early AD, achieving antibody levels several orders of magnitude higher than pre-vaccination levels. No clinically relevant adverse events were observed. AC Immune and strategic partner Janssen Pharmaceuticals, Inc., believe these interim findings from the first two dosing groups support plans to advance the development of ACI-35.030 for the treatment of AD.

Immunization with anti-Tau vaccines represents a novel strategy for the treatment of AD and other neurodegenerative diseases characterized by Tau pathology. ACI-35.030 is a first-in-class vaccine candidate designed to generate a specific antibody response against pTau proteins in the brain. Anti-pTau antibodies generated by ACI-35.030 have the potential to reduce the spread and seeding of Tau pathology, which is a major hallmark of AD.

These new results provide encouraging clinical support for ACI-35.030, which employs a new vaccine formulation to achieve active immunization that significantly improves antibody responses in older patients with potentially attenuated immune systems. Notably, anti-pTau vaccination generates antibody responses with pharmacokinetic characteristics and target epitopes that differ substantially from the Company’s anti-Tau monoclonal antibody semorinemab, highlighting the comprehensive and complementary nature of AC Immune’s anti-Tau pipeline.

Prof. Andrea Pfeifer, CEO of AC Immune SA, commented: “These remarkable data show that ACI-35.030 is capable of generating unprecedented antibody responses against pTau in an elderly population, with very high antigen-specific titers. Importantly, it generated a much stronger antibody response compared to direct injection of exogenous antibodies. As pathological pTau is present as a precursor many years before Tau accumulation in the brain is detectable via brain imaging, such results highlight the significant promise of ACI-35.030 as an early intervention for AD, especially when combined with cutting-edge pTau diagnostics that would enable identification of people at risk of developing Tau-driven disease. We look forward to continuing to advance ACI-35.030 in our collaboration with Janssen Pharmaceuticals, Inc., as we aim to bring this potentially breakthrough vaccine to patients.”

Interim data from the Phase 1b/2a study showed:

Anti-Tau IgG response preferentially targets phosphorylated Tau in all patients;
100% of patients demonstrated an anti-pTau IgG response after the 1st injection for both lowest and second highest dosages;
Very high anti-pTau IgG titers observed following injection;
Anti-pTau IgM response was also elicited in all patients for both doses;
ACI-35.030 was safe and well tolerated with no clinically relevant safety concerns observed to date.
The companies plan to advance to the third and highest dosing group, per the study protocol.

ACI-35.030 is derived from AC Immune's proprietary SupraAntigenTM platform, which accelerates the discovery and development of conformation specific antibodies and vaccine candidates to power successful therapeutic and diagnostic approaches. Additional clinical-stage candidates derived from this platform include ACI-24, a proprietary anti-amyloid beta (Abeta) vaccine, crenezumab, an anti-Abeta monoclonal antibody, and semorinemab, an anti-Tau monoclonal antibody, which is in Phase 2 development for the treatment of moderate AD.

AC Immune’s SupraAntigenTM platform has also more recently generated conformation-specific antibodies against emerging neurodegenerative disease targets such as alpha-synuclein, TDP-43 and the NLRP3 inflammasome pathway. AC Immune’s programs directed against these emerging targets are among the most advanced and comprehensive in the field.

About the Phase 1b/2a pTau AD Vaccine Trial

AC Immune’s Phase 1b/2a pTau AD vaccine trial is a randomized, multicenter, double-blind, placebo-controlled clinical study with a primary objective to assess the safety, tolerability and immunogenicity of different doses of ACI-35.030 over a 48-week treatment phase in 32 patients with early AD. Other endpoints will assess clinical and cognitive parameters as well as additional immunogenicity and safety parameters.

About ACI-35.030

ACI-35.030 is a potent liposomal anti-pTau active investigational vaccine designed to elicit antibodies against phosphorylated pathological Tau protein. It is designed to reduce and facilitate the clearance of related Tau aggregates, slowing the progression of Tau-pathology and/or treating the underlying Tauopathy.

It builds on the success of AC Immune’s ACI-35 vaccine, which demonstrated an early target-specific antibody response against pTau after the first injection in the vast majority of participants in a Phase 1b study in mild-to-moderate AD. In preclinical studies, ACI-35.030 retained the excellent non-clinical safety profile and the highly specific antibody response against phosphorylated pathological Tau produced by ACI-35, while demonstrating an enhanced and more homogeneous antibody response.

AC Immune is developing the ACI-35.030 vaccine in collaboration with Janssen Pharmaceuticals, Inc., under a 2014 licensing agreement to develop and commercialize therapeutic anti-Tau vaccines for the treatment of AD and potentially other Tauopathies.

About AC Immune SA
AC Immune SA is a Nasdaq-listed clinical-stage biopharmaceutical company, which aims to become a global leader in precision medicine for neurodegenerative diseases. The Company utilizes two proprietary platforms, SupraAntigenTM and MorphomerTM, to design, discover and develop small molecule and biological therapeutics as well as diagnostic products intended to diagnose, prevent and modify neurodegenerative diseases caused by misfolding proteins. The Company's pipeline features nine therapeutic and three diagnostic product candidates, with six currently in clinical trials. It has collaborations with major pharmaceutical companies including Genentech, a member of the Roche Group, Eli Lilly and Company and Janssen Pharmaceuticals.

For further information, please contact:

Head of Investor Relations
Joshua Drumm, Ph.D.
AC Immune
Phone: +1 917 809 0814
Email: joshua.drumm@acimmune.com
US Media
Katie Gallagher
LaVoie Health Science
Phone: +1 617 792 3937
Email: kgallagher@lavoiehealthscience.com

European Investors & Media
Chris Maggos
LifeSci Advisors
Phone: +41 79 367 6254
Email: chris@lifesciadvisors.com
Forward looking statements
This press release contains statements that constitute “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Forward-looking statements are statements other than historical fact and may include statements that address future operating, financial or business performance or AC Immune’s strategies or expectations. In some cases, you can identify these statements by forward-looking words such as “may,” “might,” “will,” “should,” “expects,” “plans,” “anticipates,” “believes,” “estimates,” “predicts,” “projects,” “potential,” “outlook” or “continue,” and other comparable terminology. Forward-looking statements are based on management’s current expectations and beliefs and involve significant risks and uncertainties that could cause actual results, developments and business decisions to differ materially from those contemplated by these statements. These risks and uncertainties include those described under the captions “Item 3. Key Information – Risk Factors” and “Item 5. Operating and Financial Review and Prospects” in AC Immune’s Annual Report on Form 20-F and other filings with the Securities and Exchange Commission. These include: the impact of Covid-19 on our business, suppliers, patients and employees and any other impact of Covid-19. Forward-looking statements speak only as of the date they are made, and AC Immune does not undertake any obligation to update them in light of new information, future developments or otherwise, except as may be required under applicable law. All forward-looking statements are qualified in their entirety by this cautionary statement.


Source: AC Immune SA
© 2021 GlobeNewswire, Inc.
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whytestocks whytestocks 4 years ago
News: $ACIU Here's Why AC Immune Jumped Higher Today

Shares of AC Immune (NASDAQ: ACIU) a re up 26% at 2:23 p.m. EDT after the biotech revealed top-line results from an early-stage clinical trial testing its Alzheimer's disease vaccine, ACI-35.030, which A C Immune is developing with Johnson & Johnson (NYSE: JNJ) . Based on the ...

Got this from ACIU - Here's Why AC Immune Jumped Higher Today
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ClayTrader ClayTrader 4 years ago
* * $ACIU Video Chart 07-16-2020 * *

Link to Video - click here to watch the technical chart video

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Mrgood Mrgood 4 years ago
any GREEN day is a good day
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whytestocks whytestocks 4 years ago
News: $ACIU 24/7 Market News- Biotech Headlines

DENVER, Colo., July 16, 2020- Today’s biotech headlines include developments from Emmaus Life Sciences, Inc. (OTCQB:EMMA), AC Immune SA (NASDAQ:ACIU), and Nabriva Therapeutics plc (NASDAQ:NBRV). Emmaus Life Sciences, Inc. (OTCQB:EMMA), a leader in sickle cell disease treatment, announced ...

Got this from ACIU - 24/7 Market News- Biotech Headlines
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whytestocks whytestocks 4 years ago
News: $ACIU AC Immune Advances phospho-Tau Alzheimer's Vaccine in Phase 1b/2a Study

Interim data confirm the promising safety, tolerability and Tau-specific immunogenicity observed in the previous clinical study ACI-35.030 is a clinical stage vaccine generated with the proprietary SupraAntigen ™ platform addressing proteinopathies across neurodegenerative dise...

In case you are interested ACIU - AC Immune Advances phospho-Tau Alzheimer's Vaccine in Phase 1b/2a Study
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$$$-Play $$$-Play 4 years ago
Nice trap! Weak open, vwap reclaim. Pm high to break is next target.
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Mrgood Mrgood 4 years ago
Will get exciting if/when they get to stage 3
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$$$-Play $$$-Play 4 years ago
Agree. Could be a short trap. They make it look weak now. Early shorts pilling in abd we coukd get a r/g move for break over P M high. Will see, all depends on volume coming in.
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Mrgood Mrgood 4 years ago
Nice pre market action
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crudeoil24 crudeoil24 4 years ago
AC Immune Advances Phospho-Tau Alzheimer's Vaccine In Phase 1b/2a Study
7:04 am ET July 16, 2020 (Benzinga) Print
Interim data confirm the promising safety, tolerability and Tau-specific immunogenicity observed in the previous clinical study

ACI-35.030 is a clinical stage vaccine generated with the proprietary SupraAntigen™ platform addressing proteinopathies across neurodegenerative diseases

LAUSANNE, Switzerland, July 16, 2020 (GLOBE NEWSWIRE) -- AC Immune SA (NASDAQ:ACIU), a Swiss-based, clinical-stage biopharmaceutical company with a broad pipeline focused on neurodegenerative diseases, today announced the initiation of the second highest dosing group in the Company's Phase 1b/2a clinical trial evaluating ACI-35.030 for the treatment of Alzheimer's disease (AD). The decision to advance to the higher dosing group follows encouraging interim safety, tolerability and immunogenicity results from the initial dosing group.

Immunization with anti-Tau vaccines has become an important strategy for the treatment of AD and other neurodegenerative diseases characterized by Tau pathology. ACI-35.030, which is being developed in collaboration with Janssen Pharmaceuticals, Inc., is the first AD vaccine candidate designed to generate a specific antibody response against pathologic phospho-Tau (pTau) proteins in the brain. Anti-pTau antibodies generated by ACI-35.030 have the potential to reduce the spread and seeding of Tau pathology throughout the brain.
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whytestocks whytestocks 5 years ago
News: $ACIU AC Immune to Present at Jefferies 2019 London Healthcare Conference

LAUSANNE, Switzerland, Nov. 14, 2019 (GLOBE NEWSWIRE) -- AC Immune SA (NASDAQ: ACIU), a Swiss-based biopharmaceutical company with a broad clinical-stage pipeline focused on neurodegenerative diseases, today announced that it will present at Jefferies 2019 London Healthcare Conference in Lo...

In case you are interested ACIU - AC Immune to Present at Jefferies 2019 London Healthcare Conference
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whytestocks whytestocks 5 years ago
News: $ACIU AC Immune Q3 2019 Financial Results and Business Update

 CHF 32 Million in Milestone Revenues Multiple Upcoming Catalysts Execution Across Clinical and Preclinical Neurodegenerative Development Pipeline LAUSANNE, Switzerland, Nov. 13, 2019 (GLOBE NEWSWIRE) -- AC Immune SA (NASDAQ: ACIU), a Swiss-based biopharmaceutical...

In case you are interested ACIU - AC Immune Q3 2019 Financial Results and Business Update
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Screech691 Screech691 5 years ago
volume alert, I'm loaded
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dAWG44 dAWG44 5 years ago
What do you all use to find potential big gainers in bio tech market? Besides the catalyst site, is there something more? Thanks
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