RNS Number:0917O
British Biotech PLC
29 July 2003

To: RNS

SECTIONS 198 and 199 COMPANIES' ACT 1985 - DISCLOSABLE INTERESTS IN SHARES

I am writing to inform you that British Biotech plc has today been notified
under Section 198/199 Companies' Act 1985 of the following disclosable interests
in the Company's shares. The overall interest is an increase of 100,000 shares,
as follows:

Name:                 Amvescap plc and subsidiary companies

No. of shares:        14,759,485 (representing 22.11%)

Date of transaction:  28th July 2003

I would further advise that the above holding includes the following notifiable 
holdings:

(a)    Invesco Perpetual High Income Fund holds 3,269,315 shares which 
       represents a 4.89% shareholding; and
(b)    Invesco Perpetual UK Growth Fund holds 2,256,157 shares which represents 
       a 3.37% shareholding;

both of which are registered in the name of Vidacos Nominees Limited; and

(c)    St. James' Place Net Income Distribution Fund holds 2,146,201 shares 
       which represents a 3.21% shareholding and this is registered in the name 
       of HSBC Nominees Limited;

From:
 
Jonathan Bond 
Head of Legal Services & Company Secretary
British Biotech
 

To: British Biotech PLC

SECTION 198 COMPANIES ACT 1985 ("THE ACT")

We write to give you notice that, following the purchase of 100,000 shares on
28th July 2003, AMVESCAP PLC (AMVESCAP) and subsidiary companies on behalf of
discretionary clients have an interest within the meaning of Part VI of the Act
in 14,759,485 Ordinary 5p Shares of your Company (representing 22.11%*); details
of that interest, together with a breakdown between registered holders (as
required by Section 202(3) of the Act), are set out below:-

Vidacos Nominees Limited                     10,466,929 
HSBC Nominees Limited                         2,752,787 
Chase Nominees Limited                          372,389 
Bank of New York Nominees Limited               986,792 
Northern Trust Nominees Limited                 178,870 
CM Investment Nominees Limited                    1,718

We wish to advise you that none of these shares are beneficially owned by
AMVESCAP Subsidiary companies of AMVESCAP have a large number of portfolio
management clients for whom they act as investment manager and investment
advisor and by virtue of Section 203 of the Companies Act 1985 AMVESCAP is
deemed to have the same interest in the shares.

We would further advise that the above holding includes the following notifiable
holdings:- INVESCO Perpetual High Income Fund holds 3,269,315 shares (4.89%*) 
and INVESCO Perpetual UK Growth Fund holds 2,256,157 shares (3.37%*), both
registered in the name of Vidacos Nominees Limited.  St. James' Place Net Income
Distribution Fund holds 2,146,201 shares (3.21%*) registered in the name of
HSBC Nominees Limited.

* Based on an issued share capital of 66,751,780

From: AMVESCAP PLC
 



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            The company news service from the London Stock Exchange

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