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Immatics NV

Immatics NV (IMTX)

7.85
0.17
(2.21%)
At close: December 06 4:00PM
7.85
0.005
( 0.06% )
After Hours: 5:22PM

Calls

StrikeBid PriceAsk PriceLast PriceMidpointChangeChange %VolumeOPEN INTLast Trade
1.000.000.000.000.000.000.00 %00-
2.000.000.000.000.000.000.00 %00-
3.002.706.000.004.350.000.00 %00-
4.000.000.000.000.000.000.00 %00-
5.001.303.700.002.500.000.00 %00-
6.000.000.000.000.000.000.00 %00-
7.000.000.000.000.000.000.00 %00-
8.000.000.000.000.000.000.00 %00-
9.000.680.050.680.3650.000.00 %02-
10.000.000.000.000.000.000.00 %00-
11.000.000.000.000.000.000.00 %00-
12.000.350.350.350.350.000.00 %010-
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15.000.000.000.000.000.000.00 %00-
16.000.000.000.000.000.000.00 %00-
17.000.000.000.000.000.000.00 %00-

Professional-Grade Tools, for Individual Investors.

Puts

StrikeBid PriceAsk PriceLast PriceMidpointChangeChange %VolumeOPEN INTLast Trade
1.000.000.750.000.000.000.00 %00-
2.000.000.000.000.000.000.00 %00-
3.000.000.000.000.000.000.00 %00-
4.000.000.750.000.000.000.00 %00-
5.000.000.000.000.000.000.00 %00-
6.000.000.000.000.000.000.00 %00-
7.000.000.250.000.000.000.00 %00-
8.000.101.950.701.0250.000.00 %06-
9.001.001.451.001.2250.000.00 %04,037-
10.000.000.000.000.000.000.00 %00-
11.000.000.000.000.000.000.00 %00-
12.003.404.800.004.100.000.00 %00-
13.000.000.000.000.000.000.00 %00-
14.004.308.000.006.150.000.00 %00-
15.006.407.900.007.150.000.00 %00-
16.006.609.700.008.150.000.00 %00-
17.007.6010.200.008.900.000.00 %00-

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IMTX Discussion

View Posts
Solarfuture Solarfuture 12 hours ago
https://finance.yahoo.com/news/why-immatics-n-v-imtx-180757431.html

Why Is Immatics N.V. (IMTX) Among the Best Small-Cap Biotech Stocks With Massive Potential According to Hedge Funds?
Laiba Immad
Wed, December 4, 2024 at 7:07 PM GMT+1 6 min
Ad
We recently compiled a list of the 10 Best Small-Cap Biotech Stocks with Massive Potential According to Hedge Funds. In this article, we are going to take a look at where Immatics N.V. (NASDAQ:IMTX) stands against the other small-cap biotech stocks.

Revolutionizing Healthcare and Economy: The Rapid Growth of Biotechnology
The biotechnology sector is expanding quickly due to rising demand for novel therapies, technological advances, and government assistance. Advances in fields like gene editing, sequencing, personalized medicine, and artificial intelligence are making new techniques possible, while the aging population and growing healthcare demands are driving a robust market for new treatments. According to a report by McKinsey & Company, venture capital firms made approximately $52 billion in global investments in therapeutic-focused biotech companies between 2019 and 2021. Two-thirds of this sum was given to platform-tech start-up companies.

Despite its growth, many biotech companies have faced challenges in turbulent markets, taking drastic measures such as cutting programs and implementing significant layoffs to conserve cash. While recent rate cuts could encourage the revival of scientific projects, analysts like Jared Holz note the difficulty of gauging their impact. Holz also highlighted a shift in market dynamics, observing that biotech's performance increasingly correlates with small-cap equities. If small-cap stocks trade well, biotech is likely to follow, though stagnation could occur if momentum fades. Notably, the idea of interest rates predicting biotech success is relatively new, emerging only after the pandemic, which reshaped the industry by driving substantial investment into therapeutic-focused companies.

With innovative treatments, biotech businesses are revolutionizing healthcare by tackling important unmet medical needs. Establishing the National Bioeconomy Board as a component of Biden's Investing in America agenda is a significant breakthrough. It seeks to maximize biotechnology's economic potential in the United States.

Furthermore, policy suggestions to expedite the approval process for biotechnology goods are being developed by the National Security Commission on Emerging Biotechnology. More academics will be able to use biotechnology for agricultural purposes if entry obstacles are reduced, which will benefit American farmers and increase food security. It is anticipated that these initiatives will open up new markets.

Pharmaceuticals as Defensive Investments and the 2024 Healthcare Market Outlook
This year (2024) started strongly for the biotechnology sector due to a rise in mergers and acquisitions as well as anticipations of falling interest rates. Therefore, estimates suggest that the worldwide biotechnology market might increase at a compound annual growth rate (CAGR) of around 14% from 2024 to 2033, reaching an astonishing $5.7 trillion. The market for agricultural biotechnology is also expected to develop at a 7.9% compound annual growth rate (CAGR) and reach $232 billion by 2032.
But even with the market's potential, investing in biotech companies still carries a number of serious dangers. Bankruptcy may result from failing to satisfy clinical trial endpoints or obtain adequate finance before a product launch. In the biotech industry, where drug development usually takes more than ten years and has an estimated failure rate of about 90%, the danger of failure is very substantial. Hence, biotech stocks are often considered โ€œhigh-risk, high-rewardโ€ investments due to their upside potential coupled with significant risks

Our Methodology
In our methodology, we identified the top small-cap biotech stocks with significant growth potential, ranked according to their total hedge fund holdings as of Q2 2024. Our selection process began by filtering companies with a small market capitalization. Next, we reviewed analyst recommendations, focusing on stocks with strong bullish sentiment and high institutional ownership. Finally, we ranked these companies based on the number of hedge funds holding their shares as of Q2 2024.

Why are we interested in the stocks that hedge funds pile into? The reason is simple: our research has shown that we can outperform the market by imitating the top stock picks of the best hedge funds. Our quarterly newsletter's strategy selects 14 small-cap and large-cap stocks every quarter and has returned 275% since May 2014, beating its benchmark by 150 percentage points (see more details here).


A close-up of test tubes and laboratory equipment, showing the complexity of biopharmaceutical research.

Immatics N.V. (NASDAQ:IMTX)
Number of Hedge Fund Holders: 32

Immatics N.V. (NASDAQ:IMTX) is a clinical-stage biopharmaceutical company focused on developing innovative cancer immunotherapies. At its core, the company specializes in discovering and developing novel T-cell receptor (TCR)-based therapies for cancer treatment.

Immatics N.V. (NASDAQ:IMTX) is advancing two types of therapies: Engineered Adoptive Cell Therapies (ACTengine) and antibody-like TCR Bispecifics (TCER), aimed at different stages of solid tumors. Its lead candidate, IMA203, has demonstrated promising clinical results, with a 55% overall response rate and a median response duration exceeding 13 months, indicating the potential for breakthrough treatments in melanoma and other solid cancers.

Immatics N.V. (NASDAQ:IMTX), one of the best small-cap biotech stocks with massive potential according to hedge funds, reported a significant increase in total revenue, which rose to $56.7 million in Q3 2024, up from $6.6 million in the same quarter last year. This surge was primarily driven by a one-time revenue from the IMA401 partnership termination by Bristol Myers Squibb YoY.

The total value of cash and cash equivalents, as well as other financial assets, increased from $476.8 million in the same quarter last year to $549.2 million in Q3 2024. The increase, which was primarily brought on by the January 2024 public offering, was somewhat mitigated by ongoing research and development activities. Following its $150 million initial public offering (IPO) in October 2024, Immatics N.V. (NASDAQ:IMTX) currently projects a financial runway until the second half of 2027.

As of Q3 2024, 32 hedge funds held stakes in the company as tracked by the Insider Monkey database. The largest stakeholder in the company was Perceptive Advisors with holdings worth $92.2 million. Street analysts hold a consensus Strong Buy rating on the stock, with an average target of $18.00. The high forecast is $19.00, and the low is $16.00, representing a 90.48% increase from the current price of $9.45.
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jondoeuk jondoeuk 2 weeks ago
Still early, but based on the data, and the fact that BMY abandoned IMA401, it isn't a great vote of confidence in their bispecific platform https://markets.businessinsider.com/news/stocks/immatics-announces-clinical-data-on-tcer-ima402-targeting-prame-1034031315
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Solarfuture Solarfuture 4 weeks ago
Immatics Announces Multiple Presentations at the 39th Annual Meeting of the Society for Immunotherapy of Cancer (SITC) on TCR-T Therapy Candidates Targeting PRAME
https://ih.advfn.com/stock-market/NASDAQ/immatics-nv-IMTX/stock-news/94874399/immatics-announces-multiple-presentations-at-the-3
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Solarfuture Solarfuture 4 weeks ago
Wellington Management Group LLP Increases Stake in Immatics NV
https://www.gurufocus.com/news/2593235/wellington-management-group-llp-increases-stake-in-immatics-nv
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Monksdream Monksdream 1 month ago
IMTX under $10
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maumar maumar 2 months ago
Perceptive Advisors bought about 1.4M shares presumably at the offering price. They also added 3.5M shares in Q2. They must be pretty bullish.

https://investors.immatics.com/static-files/6d4db1b8-0525-44bf-bdd3-93a94f4ed8ed
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Solarfuture Solarfuture 2 months ago
I was disappointed too. I hope a little that perhaps other sorts of cancer could get a faster FDA Permission...
But who knows...I will wait...
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FACT-MASTER FACT-MASTER 2 months ago
The article tries to highlight the positive aspects of the news, however no mention of RMAT designation, and what that would mean to the timeline of approval.
The timeline outlined is a much longer duration for approval then the timeline generally speaking under RMAT designation. I could cite examples of 6-12 months for previous approvals under RMAT designation by other biotech companies.

Secondly, it's designated for patients that have no alternative, so imo, why should it not be fast tracked for approval if the safety and efficacy are there? Sometimes things don't make sense.

Don't mean to sound negative, however i was disappointed with this news.
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Solarfuture Solarfuture 2 months ago
https://transkript.de/artikel/2024/gute-datenlage-immatics-kann-direkt-in-phase-iii-gehen/
Good data situation: immatics can go directly into Phase III
Tรผbingen-based Immatics NV published updated Phase Ib clinical data on ACTengine® IMA203, which allow for a more in-depth analysis compared to the last data update in May 2024. The data on progression-free survival (PFS) and overall survival (OS) are so convincing that the company can proceed directly with an approval-ready Phase III study on this basis. And Immatics is using the tailwind to place new shares for $150 million.



The data from the ongoing Phase 1b study have been eagerly awaited and will only be presented tomorrow by Dr. Martin Wermke at the Society for Melanoma Research Congress 2024. However, the Tรผbingen-based company Immatics NV is making it public earlier. The observation of significant tumor shrinkage and a lasting response in combination with meaningful results on progression-free survival and overall survival after a single treatment with ACTengine® IMA203, which Dr. Martin Wermke, coordinating investigator of the TCR-T study, will present there, are simply too impressive to keep quiet any longer.

"These results now confirm the therapeutic potential of IMA203 in this patient population, all of whom have exhausted multiple lines of systemic treatment. They demonstrate the impact IMA203 can have in patients with metastatic melanoma and provide a strong rationale for accelerating late-stage clinical development of this product candidate," said Wermke.

And that is the second important part of the advance announcement before the congress presentation: With the complete study data from Phase I, Immatics can go straight into a phase III study that is relevant for approval after consultation with the FDA. Recruitment will start soon, but the company expects that it will take around a year until enough study participants have been found, and then another year until the crucial data packages can be viewed in an interim analysis.

The Type D meeting with the US Food and Drug Administration (FDA) took place at the end of September. The study design for SUPRAME (Phase III) was discussed, in which IMA203, which targets PRAME, will be investigated in 360 HLA-A*02:01-positive patients with inoperable or metastatic melanoma in the second line or later (2L+) who were previously treated with a checkpoint inhibitor.

"We are excited about the clinical data as they confirm our belief in the durability and long-term efficacy of ACTengine® IMA203, as demonstrated by the favorable median progression-free survival of patients in the dose expansion cohort. I would like to highlight that a subset of 12 of the 26 patients had a reduction in tumor lesion size of more than 50% and a median PFS of 13.4 months," said Dr. Cedrik Britten, Chief Medical Officer at Immatics. "We believe that the presentation of this data set, coupled with our recent meeting with the FDA, which resulted in a pivotal study design with progression-free survival as the primary endpoint for full approval, positions us to significantly advance the development of IMA203."

The Tรผbingen-based cell therapy company is taking advantage of the tailwind and today announced the start of a subscribed public offering for its common shares. The volume is planned to reach 150 million US dollars, but this also depends a little on the current stock market situation. However, the data could also lead to increased interest.

© |transkript.de
Georg Kรครคb
October 10, 2024
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Solarfuture Solarfuture 2 months ago
Agree!
We'll need much more patience...
9,25 the new shares...
Nevertheless have a nice weekend!
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FACT-MASTER FACT-MASTER 2 months ago
I didn't like today's news.

They received RMAT designation just shy of a year ago.

https://www.sec.gov/Archives/edgar/data/1809196/000095010323015263/dp201755_6k.htm

Something did not go right with the FDA and regulatory process,imo. I was actually expecting FDA approval of IMA203 soon.
The new timeline puts IMA203 approval a fair distance down the road.
Another offering, at what price?. This could tank more, imo.
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Solarfuture Solarfuture 2 months ago
I thought so,too...
Clinical Data don't look bad.
But the second Public Offering for this year is no good idea in my opinion...
They have cash about 500 million, so they had the chance to wait for higher share prices...
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FACT-MASTER FACT-MASTER 2 months ago
Immatics Announces Proposed $150 Million Public Offering

https://finance.yahoo.com/news/immatics-announces-proposed-150-million-113000826.html

This story is not looking as good as expected, at the moment, imo

Thought IMA203 had RMAT designation, which would mean a shorter timeline to FDA approval.
Previous press release coupled with another offering means longer timeline to approval, which means longer timeline to revenue generation, imo.

Pre-market currently $9.50
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FACT-MASTER FACT-MASTER 2 months ago
Immatics Announces Updated Phase 1b Clinical Data on ACTengine® IMA203 TCR-T Targeting PRAME in Melanoma Patients and Provides Update on Upcoming SUPRAME Phase 3 Trial

Company to host conference call and webcast today, October 10, at 9:00 am EDT/3:00 pm CEST

Company announces updated Phase 1b clinical data on ACTengine® IMA203 targeting PRAME in 28 heavily pretreated metastatic melanoma patients with substantially enhanced maturity compared to the last data update in May 2024 and provides the first report on progression-free survival (PFS) and overall survival (OS)


Based on the Phase 1b data, the Company will proceed directly to a registration-enabling Phase 3 trial


Regulatory pathway and clinical trial design for IMA203 finalized following FDA Type D meetings and meeting with the Paul Ehrlich Institute (PEI); RP2D and CMC package confirmed


IMA203 continues to maintain a favorable tolerability profile in patients in Phase 1a and Phase 1b treated across all dose levels


IMA203 demonstrates a confirmed objective response rate of 54% with median duration of response of 12.1 months in Phase 1b


Median PFS is 6 months, comparing favorably to the IMA203 Phase 1a dose escalation median PFS of 2.6 months; patients with deep responses show median PFS of more than one year; median OS not reached


Phase 3 trial, โ€œSUPRAME,โ€ will enroll 360 patients with unresectable or metastatic melanoma post treatment with a checkpoint inhibitor (2L+) and will randomize patients 1:1 for treatment with IMA203 or investigatorโ€™s choice


Primary endpoint for full approval will be median PFS, which constitutes the fastest pathway to registration in this patient population


SUPRAME Phase 3 trial is on track to commence in December 2024; enrollment forecasted to be completed in 2026 with a pre-specified interim analysis planned for early 2026


Conference call and webcast can be accessed here


Houston, Texas and Tuebingen, Germany, October 10, 2024 โ€“ Immatics N.V. (NASDAQ: IMTX, โ€œImmaticsโ€ or the โ€œCompanyโ€), a clinical-stage biopharmaceutical company active in the discovery and development of T cell-redirecting cancer immunotherapies, today announced updated Phase 1b clinical data on ACTengine® IMA203 TCR-T targeting PRAME in melanoma patients and provided an update on SUPRAME, the upcoming Phase 3 trial to evaluate IMA203 in metastatic melanoma patients.

The data from the ongoing Phase 1b trial will be presented on Friday, October 11, 2024, by Martin Wermke, M.D., during Plenary Session 1, Developmental Immunotherapy (Cellular Immunotherapy, Vaccines, & New Checkpoints) at the Society for Melanoma Research Congress 2024. The IMA203 data slides are accessible in the โ€˜Events & Presentationsโ€™ section of the Investor & Media section of the Companyโ€™s website. The conference presentation will include additional patient cases.

โ€œObserving significant tumor shrinkage and durable responses combined with meaningful progression-free survival and overall survival outcomes after a single treatment with ACTengine® IMA203 in this patient population that have all exhausted multiple lines of systemic treatments illustrates the impact IMA203 can have on metastatic melanoma patients,โ€ said Martin Wermke, M.D., Coordinating Investigator of the ACTengine® IMA203 TCR-T trial. โ€œThese results now affirm the therapeutic potential of IMA203 and provide a strong rationale for the expedited late-stage clinical development of this product candidate.โ€

โ€œWe are enthusiastic about the clinical data as they confirm our conviction in the durability and long-term efficacy of ACTengine® IMA203, demonstrated by the favorable median progression-free survival for patients in the dose expansion cohort. I would like to highlight that a subgroup of 12 out of 26 patients showed more than 50% reduction of tumor lesions and a median PFS of 13.4 months,โ€ said Cedrik Britten, M.D., Chief Medical Officer at Immatics. โ€œWe believe the presentation of this data set in conjunction with our recent meeting with the FDA, which has resulted in a pivotal trial design with progression-free survival as the primary endpoint for full approval, positions us to advance the development of IMA203 in the second-line or later metastatic melanoma setting.โ€

Patient Population and Clinical Data Summary - ACTengine® IMA203 Monotherapy Phase 1b Trial

Patient population: Heavily pretreated metastatic melanoma patients
As of August 23, 2024, 28 heavily pretreated patients with metastatic melanoma were treated at the recommended Phase 2 dose (RP2D, 1 to 10 billion total TCR-T cells) with IMA203 during the Phase 1b dose expansion part of the clinical trial. The treated patient population is composed of patients with a median of 2 lines of prior systemic treatments, consisting of cutaneous melanoma patients (N=13), uveal melanoma patients (N=12), mucosal melanoma patients (N=2) and a patient with melanoma of unknown primary (N=1).

Safety: Favorable tolerability profile demonstrated across all dose levels in Phase 1a and Phase 1b
IMA203 monotherapy has maintained a favorable tolerability profile with no treatment-related Grade 5 adverse events in the safety population (N=701 Phase 1a and Phase 1b patients across all dose levels and all tumor types), even at doses up to ~10x109 TCR-T cells.

The most frequent adverse events were expected cytopenias (Grade 1 โ€“ 4) associated with lymphodepletion as well as mostly mild to moderate cytokine release syndrome (CRS). Some patients infrequently experienced ICANS (Grade 1: 6%, Grade 2: 4%, Grade 3: 4%).

The full IMA203 monotherapy tolerability profile is also generally consistent with that observed in the Phase 1b melanoma subset.

Anti-tumor activity and durability: Durable objective responses in melanoma patients at RP2D3
This data update adds substantial maturity to the most recent data update from May 2024 (data cut-off on April 25, 2024). The median follow-up for the median duration of response for this analysis was 9.3 months compared to 3.5 months in May 2024.



All melanoma patients in Phase 1b
(N=282,3)

Cutaneous melanoma patients in Phase 1b (N=133)







Confirmed Objective Response Rate

54% (14/26)

54% (7/13)

Objective Response Rate

62% (16/26)

62% (8/13)

Disease Control Rate

92% (24/26)

92% (12/13)

Tumor Shrinkage

88% (23/26)

85% (11/13)

Median Duration of Response

12.1 months

12.1 months

Median Progression-Free Survival

6.0 months

6.1 months

Median Overall Survival

Not reached

15.9 months

Progression-free survival (PFS) and overall survival (OS): Significant shift in PFS and OS between Phase 1a dose escalation to Phase 1b dose expansion in melanoma patients
Manufacturing improvements were implemented prior to the Phase 1b part of the trial to enhance key features of IMA203. As a result, all patients in dose expansion were treated with an updated version of IMA203 that includes a T cell enrichment process using monocyte depletion (negative selection) or CD8/CD4 positive selection.

The data presented today demonstrate a significant positive shift in median PFS and median OS between melanoma patients treated during Phase 1a and patients treated in Phase 1b.



Phase 1b dose expansion melanoma patients
(N=28)

Phase 1a dose escalation melanoma patients
(N=11)







Median Progression-Free Survival

6.0 months

2.6 months

Median Overall Survival

Not reached

6.3 months

In addition, approximately half of all patients in the Phase 1b trial have a deep response (>50% tumor reduction). This subgroup of patients was observed to have a median PFS of more than one year, while patients with <50% tumor reduction (including patients with tumor size increase) were still observed with a more than 2 times longer median PFS compared to patients treated in dose escalation with suboptimal doses.

Translational data: IMA203 T cell dose and T cell exposure are associated with clinical responses
Translational data from patients across Phase 1a and Phase 1b indicate that IMA203 T cells rapidly engrafted in all patients after a single dose and show a persistence of more than two years. Three associations/correlations were observed demonstrating high consistency of dose exposure, biological data and clinical outcome in all patients treated with IMA203 for which samples were available (N=65):

IMA203 T cell dose is significantly associated with confirmed clinical responses (p=0.02),
IMA203 T cell dose is correlated with T cell peak level (cmax, r=0.84, p=1.6x10-18),
IMA203 T cell peak level (cmax, p=0.05) and T cell exposure (AUC0-28d, p=0.05) are associated with confirmed clinical responses.

Development Path and Manufacturing for ACTengine® IMA203 Monotherapy

On September 24, 2024, Immatics completed a Type D meeting with the U.S. Food and Drug Administration (FDA) to confirm RP2D and the CMC package as well as discuss the trial design for SUPRAME, the planned registration-enabling Phase 3 randomized-controlled clinical trial for IMA203. Written post-meeting minutes from the FDA have been received.

The Phase 3 trial will evaluate IMA203 targeting PRAME in 360 HLA-A*02:01-positive patients with second-line or later (2L+) unresectable or metastatic melanoma who have received prior treatment with a checkpoint inhibitor. Patients will be randomized 1:1 for IMA203 or investigatorโ€™s choice of selected approved treatments in the 2L+ setting.

Based on the Companyโ€™s discussions with the FDA, the primary endpoint for full approval will be median PFS. Given the expected PFS of 2-3 months4 in this patient population, as well as the PFS of 6 months observed in the data from the IMA203 Phase 1b trial, the Company has determined that utilizing median PFS as the primary endpoint is the fastest pathway to seeking full approval and presents a more attractive commercial positioning as compared to objective response rate (ORR). Secondary endpoints for the trial will include ORR, safety, duration of response, no overall survival detriment and patient-reported outcomes. A pre-specified interim analysis is planned for early 2026.

The SUPRAME Phase 3 trial is planned to run globally with sites in the United States and Europe with the initial goal of seeking Biologics License Application (BLA) approval in the United States. On October 2, 2024, Immatics also completed a meeting with the Paul Ehrlich Institute (PEI), the German regulatory authority, and determined the same trial design for conducting the clinical trial in Germany.

The Phase 3 trial is on track to commence in December 2024 and patient enrollment is forecasted to be completed in 2026. The Company aims to submit a BLA in early 2027 for full approval.

Immaticsโ€™ late-stage clinical cell therapy development is supported by its differentiated manufacturing related to timeline, capabilities and facilities. ACTengine® IMA203 cell therapy products are manufactured within 7 days, followed by a 7-day QC release testing at a success rate of >95% to reach the target dose. The Company has also completed construction of a ~100,000 square foot R&D and GMP manufacturing facility with a modular design for efficient and cost-effective scalability intended to serve early-stage and registration-enabling trials, as well as commercial supply. The new site is expected to start GMP manufacturing of cell therapy products in early 2025. Meanwhile, the existing GMP facility, which is run in collaboration with UT Health, will remain active until YE 2025.

Immatics Conference Call and Webcast
Immatics will host a conference call and webcast today, October 10, 2024, at 9:00 am EDT/ 3:00 pm CEST to discuss the clinical data.

A replay of the webcast will be made available shortly after the conclusion of the call and archived on the Immatics website for at least 90 days.

About ACTengine® IMA203 and Target PRAME
ACTengine® IMA203 is Immaticsโ€™ most advanced TCR-based autologous cell therapy that is directed against an HLA-A*02-presented (human leukocyte antigen) peptide derived from preferentially expressed antigen in melanoma (PRAME), a protein frequently expressed in a large variety of solid cancers. PRAME is homogeneously and specifically expressed in tumor tissue and Immaticsโ€™ PRAME peptide is present at a high copy number per tumor cell. The peptide has been identified and characterized by Immaticsโ€™ proprietary mass spectrometry-based target discovery platform, XPRESIDENT®. Through its proprietary TCR discovery and engineering platform XCEPTOR®, Immatics has generated a highly specific T cell receptor (TCR) against this target for ACTengine® IMA203.
ACTengine® IMA203 TCR-T is currently being evaluated as a monotherapy in a Phase 1 clinical trial in patients with solid tumors expressing PRAME, such as cutaneous melanoma. An IMA203 registration-enabling randomized controlled Phase 3 trial, โ€œSUPRAME,โ€ is planned to commence in December 2024.

ACTengine® IMA203 TCR-T is also currently being evaluated in Phase 1 IMA203CD8 (GEN2) monotherapy, where IMA203 engineered T cells are co-transduced with a CD8aß co-receptor.

- END -

https://finance.yahoo.com/news/immatics-announces-updated-phase-1b-103000214.html
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Solarfuture Solarfuture 2 months ago
Immatics () has received a new Buy rating, initiated by Piper Sandler analyst, .

Joseph Catanzaro has given his Buy rating due to a combination of factors surrounding Immaticsโ€™ potential in the biotechnology sector. He identifies the companyโ€™s PRAME-targeting portfolio as having extensive utility across various solid tumors. Catanzaro is particularly impressed by Immaticsโ€™ lead program, IMA203, which he believes could offer superior cell therapy for post-PD-1 melanoma based on scenario modeling that indicates competitive durability and potential for registrational development. Furthermore, he sees substantial opportunity for Immaticsโ€™ cell therapy portfolio beyond melanoma, particularly with IMA203CD8, which could show meaningful clinical activity in ovarian, endometrial, and lung cancers. Catanzaroโ€™s outlook suggests that Immaticsโ€™ pipeline could lead to blockbuster therapies, with data expected in the next 6-18 months that could further reduce investment risks.
The positive rating also stems from validation of Immaticsโ€™ proprietary platforms, XPRESIDENT and XCEPTOR, which are starting to show clinical validation in their abilities to identify relevant peptide targets and generate highly active TCRs. These platforms have positioned Immatics to build a pipeline capable of developing first-in-class or best-in-class therapies for solid tumor indications. The report also highlights the competitive profile of the IMA203 program in post-PD-1 melanoma, noting its potential for best-in-indication response rates, competitive durability, and favorable safety profile. Lastly, Catanzaro emphasizes the potential of Immaticsโ€™ PRAME-targeting portfolio outside of melanoma, supported by strong evidence from clinical datasets and the enhanced efficacy observed with the incorporation of the CD8 co-receptor. Despite the inherent risks in clinical, regulatory, and commercial areas, Catanzaroโ€™s analysis suggests a strong Buy recommendation for Immatics.
https://www.tipranks.com/news/blurbs/immatics-promising-pipeline-and-buy-recommendation-a-comprehensive-analysis-by-joseph-catanzaro?mod=mw_quote_news
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Solarfuture Solarfuture 2 months ago
That's fine!
Yes, think we have good chance to see some nice weeks coming up...

Interesting article:
At the European Cancer Congress ESMO in Barcelona, Tรผbingen-based immatics NV did not present any new data on advanced T-cell therapy developments, but rather early data on the bispecific approach of a T-cell receptor against MAGEA4/8. The fact that the partner Bristol Myers Squibb is backing out of this previously collaborative development is only reported as a side note.


The many good news reports on advances in the treatment of cancer at the ESMO Congress in Barcelona in mid-September have given some companies like BioNTech a real boost, with their share prices soaring in just a few days. Tรผbingen-based immatics NV, on the other hand, did not choose the more advanced development of the so-called ACT engine, which is currently being evaluated in phase Ib either on its own or in combination with a CD8 binding site, as its presentation topic. This study is to continue with an increased dosage and will then be presented at another conference a little later in the year.

In contrast, Immatics' previous, preclinical approach to a bispecific T cell engaging receptor (TCER®) candidate, IMA401, was presented at the current conference. This is derived from a technology for the production of next-generation bispecific TCR molecules with an extended half-life. The molecules were developed to "maximize efficacy while minimizing toxicities," according to the company. The proprietary format, consisting of a high-affinity TCR domain against the tumor target and a low-affinity T cell recruiter that binds to the T cell, offers a more convenient dosing regimen for the patient than if such molecular capabilities had to be administered as individual active ingredients in combination.

Dr. Martin Wermke from the University Hospital Dresden presented the first clinical data of IMA401 (directed against the tumor antigen MAGEA4/8), which provided information on the safety, pharmacokinetics and antitumor activity of TCER IMA401 from the phase I dose escalation. These data show initial anti-tumor activity and a manageable tolerability profile for TCER® IMA401 monotherapy. The patient population includes 35 heavily pretreated patients with a total of 16 different solid tumor types; the dose escalation is now ongoing.

Only 29% was considered to be an objective response rate (ORR), or even 25% in the confirmed ORR (cORR). Nevertheless, a disease control rate (DCR) of 53% and a tumor shrinkage rate of 53% were shown in the "efficacy population" (i.e. those who responded). In addition, a "sustained partial response" of up to 13+ months and a deeper response (with tumor shrinkage of ≥50%) were shown in very different tumors, which is now being used as a justification for continuing and further increasing the dosage.

It was announced in passing that the previous development partner Bristol Myers Squibb is withdrawing from this sub-project of a broader development partnership (which was reported in the news a few months ago when it was converted into a shareholder ) and that immatics is giving back all rights. The stock market remained quiet, probably because immatics is currently extremely well financed with a good 530 million euros in the bank to take the next development steps on its own. The presentations from the adoptive, modified cell therapy development track will now receive much more attention, because the next approval-relevant studies are due to be carried out there after good data. Things remain exciting in Tรผbingen.

© |transkript.de
Georg Kรคab
17. September 2024

https://transkript.de/artikel/2024/hoch-und-tief-bei-immatics/
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FACT-MASTER FACT-MASTER 2 months ago
Thanks for pointing that out! That sounds very promising.

Given TCRX's success with targetting prame with leukemia, this does sound exceptionally promising.

TCRX has data showing durable activity with complete donor chimerism (they have used the word "cure" in some of their presentations)

Have a look here: ( slide 13/14 of particular interest)

https://ir.tscan.com/static-files/1d066354-1ed3-4f4f-b97b-28806d9da9f5

This data provides a good indicator, imo for IMTX"s upcoming presentation that you referenced.

Doing well, however busy with my work.
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Solarfuture Solarfuture 2 months ago
Thank you!
I like the title:
ACTengine IMA203 TCR-T targeting PRAME shows deep and durable anti-tumor activity in heavily pretreated solid cancer patients

Sounds promising!
All is well here - hope so, too!?
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FACT-MASTER FACT-MASTER 2 months ago
IMTX: Immatics Announces Upcoming Oral and Poster Presentations at the Society for Immunotherapy of Cancer Annual Meeting 2024. ( being held in Houston Texas, November 6-10)

https://finance.yahoo.com/news/immatics-announces-upcoming-oral-poster-130000202.html

2 Oral Presentations and 5 Poster Presentations!

Looks like a major event , and if i recall correctly, Immatics was working on opening a facility in Houston Texas. I'll see if i can find that in their sec filings.

Hope all is well over there!
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Solarfuture Solarfuture 3 months ago
Agree.
Think we have good chance to see nice development here for the rest of the year and later...
Good time to you...
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FACT-MASTER FACT-MASTER 3 months ago
Just doing a review of IMA402 before shutting down for some shut eye over here:

Previous presentation on IMA402:
https://investors.immatics.com/static-files/7d8a3d13-c638-4a5b-8317-5d4f0b28dba3

Impressive pre-clinical work, imo

Clinical Trial:
https://clinicaltrials.gov/study/NCT05958121?tab=history&a=15#version-content-panel

Even though the stock sold off a bit today, it still seems to me that more good news could be coming.
I saw that pre-market $11.40 the other day too, and thought we were going to get hit hard Monday.. We are still above $12 and there was much buying today at higher prices.
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Solarfuture Solarfuture 3 months ago
9th Annual CAR-TCR Summit
Sep 17 - Sep 20, 2024

The Immatics team will attend the CAR-TCR Summit.



For more information, visit the summit website by clicking here.



Location

Boston, Massachusetts, USA
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Solarfuture Solarfuture 3 months ago
Yes it was...
There will be more news soon.
The first premarket was 11,40...So it was a great day...
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FACT-MASTER FACT-MASTER 3 months ago
Yes we did, last at $12.73 on over 1 million shares

High of the day was $13.09

This was an excellent day imo, given the not so good news, on IMA401.
I personally thought the stock was going to get punished, so i see today's action as highly positive.
Possibly there is good news around the corner on IMA203 and/or IMA402.

I guess we will see in the coming days.
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Solarfuture Solarfuture 3 months ago
I agree...
Perhaps we will close green....
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FACT-MASTER FACT-MASTER 3 months ago
I concur, the company appears to still be positive on IMA401 so there could be some other data they have. Also, these were all heavily pretreated patients, so patients that likely do not have any other alternative or their current therapies like chemo etc were not working.
imo, the Immatics therapy should be trialed as first line - chemo and other therapies actual cause certain mutations as far as i have researched, however the regulatory processes are just not that easy.

Stock is holding up well in early morning trading.

Looking forward to the data on IMA203 in October.
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Solarfuture Solarfuture 3 months ago
Ah okay...
In the end this could be an advantage to have all rights back IMO...
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FACT-MASTER FACT-MASTER 3 months ago
Those are good points.

Reading this over again, i think BMS is just pulling out of the IMA401 program. Here, Immatics already updated their pipeline web page.
BMS is still listed under the Autologous and Allogeneic programs.

https://immatics.com/our-pipeline/
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Solarfuture Solarfuture 3 months ago
Not really...
I did some DD on BMS. At the moment they seem to have more problems with their own business and their numbers. I think the reason for this decission is more likely to find by BMS themselves than by Immatics.
My second thought was: If BMS is out Immatics could be much more attractive for M & A...
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Solarfuture Solarfuture 3 months ago
Not really...
I did some DD on BMS. At the moment they seem to have more problems with their own business and their numbers. I think the reason for this decission is more likely to find by BMS themselves than by Immatics.
My second thought was: If BMS is out Immatics could be much more attractive for M & A...
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FACT-MASTER FACT-MASTER 3 months ago
News out this morning on IMA401

Not as good as i was thinking yesterday, also looks like BMS is pulling out.
https://finance.yahoo.com/news/immatics-presents-clinical-proof-concept-092500575.html

Remember this was targetting mage, IMA402 was targetting prame, so there is still hope those results are better. Hope we get an update on IMA402 before year end. TCRX has had excellent success with leukemia targetting prame.
I have to admit today's news is not that good, imo
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Solarfuture Solarfuture 3 months ago
Interesting thoughts! But could be!
Let's do so!
Looking for a nice week/weeks here...
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FACT-MASTER FACT-MASTER 3 months ago
I'll add this analysis to the article:

1. Institutional ownership at June 30/24 = 75%
https://www.nasdaq.com/market-activity/stocks/imtx/institutional-holdings

2. Short position at 08/30/2024 = 10,415,614\
https://www.nasdaq.com/market-activity/stocks/imtx/short-interest

Could the upcoming data release at the upcoming ESMO (tomorrow) and Society for Melanoma Research Congress (Oct.11/24) cause a short squeeze?
The above evidence demonstrates that in this instance, it could be a real possibility, imo.

Let's keep in touch.
FM
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FACT-MASTER FACT-MASTER 3 months ago
Noticed IMA402 was mentioned in the Q1 report and was initially focused on melanoma (similar to IMA203) Not sure when results will be coming out on IMA402, however from the article you posted, this trial could be well advanced. The announcement regarding the Oral Presentation at the Society for Melanoma Research Congress 2024 - October 11/24 only mentions IMA203. (https://finance.yahoo.com/news/immatics-announces-upcoming-oral-presentation-110000681.html)

I'll whisper this: Given that IMA203 received RMAT designation almost a year ago, i speculate that it is a distince possibility that FDA approval will be announced for IMA203 in and around the Melanoma Research Congress October 10-13/24 in New Orleans, Louisiana - just my opinion.



https://finance.yahoo.com/news/immatics-announces-first-quarter-2024-110000778.html

TCER® IMA402 (PRAME)

Immatics initiated the Phase 1/2 trial investigating the companyโ€™s fully owned TCER® candidate IMA402 in patients with recurrent and/or refractory solid tumors in August 2023 and the first patients have been dosed. Initial focus indications are ovarian cancer, lung cancer, uterine cancer and cutaneous and uveal melanoma, among others. IMA402 targets an HLA-A*02:01-presented peptide derived from the tumor antigen PRAME. This target peptide has been selected based on natural expression in native solid primary tumors and metastases at particularly high target density (peptide copy number per tumor cell identified by Immaticsโ€™ proprietary quantitative mass spectrometry engine XPRESIDENT®).

Immatics has recently engaged Patheon UK Limited, a subsidiary of ThermoFisher Scientific Inc., for the manufacturing of clinical IMA402 batches for its use within a potential registration-enabling trial. Patient recruitment and dose escalation continue to scale. First clinical data in at least 15 patients in dose escalation across multiple solid cancers, but initially focused on melanoma, is anticipated to be announced in 2H 2024.
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FACT-MASTER FACT-MASTER 3 months ago
Well thank you for sharing that interesting article. I note that it references IMA402 which is Immatics proprietary targeting prame.

https://www.boerse-online.de/nachrichten/aktien/geheimtipp-diese-voellig-unbekannte-biotech-aktie-aus-deutschland-hat-niemand-auf-dem-schirm-20352622.html

Insider tip? Nobody has this completely unknown biotech stock from Germany on their radar

Along with BioNTech and other pharmaceutical companies, the shares of this German company are a hot candidate for a big price jump in 2024.

More than just BioNTech. Anyone looking for German biotech stocks will quickly end up with the Mainz stocks. There are other promising stocks that speculative investors should at least keep an eye on. For example, there is Immatics from Tübingen. The company focuses on the development and production of T cell-based immunotherapies for the treatment of cancer. What sounds complicated is essentially aimed at modifying T cells and then developing an immunotherapy that selectively and effectively attacks a patient's tumors.

The research on this takes place at three locations: Tübingen, Texas and Munich. The group also works with some well-known biotech giants such as Bristol-Myers-Squibb, Genmab and Moderna, who actively promote research. With more than 500 million US dollars, Immatics has enough financial resources to carry out clinical studies on the various active ingredients. 2024 could be a particularly exciting year for investors.

Will 2024 boost Immatics shares?
โ€œWe are working intensively to make IMA402 available to a broad patient population as quickly as possible and look forward to publishing the first clinical data in 2024,โ€ the company announced last year. And the active ingredient for the treatment of cancer called IMA402 is not the only drug about which there could be news this year. There will also be new data for the active ingredient IMA-203 this year. In total, the Germans are currently preparing eleven treatments or are already in the first clinical study phases.

The year could have some surprises in store for the stock. The fact that the stock reacts to even small results was shown last year when the price shot up by 30 percent in one day after the publication of some clinical data.

That's what the analysts say
The stock is currently not receiving much attention from analysts on Wall Street. A current analysis by Mizuho Securities still believes the stock will have a medium-term price increase of over 13 percent. Two other analyzes at the end of last year were significantly higher. Leerink Partners even believed the stock had 86.69 upside potential and Chardan Capital had an incredible 103 percent.

According to data from the MarketScreener platform, six analysts currently recommend buying the stock. The average price potential is almost 60 percent. Risk-taking investors should therefore not lose sight of the stock this year.
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Solarfuture Solarfuture 3 months ago
Perhaps interesting to read for you with google translate....

https://www.boerse-online.de/nachrichten/aktien/geheimtipp-diese-voellig-unbekannte-biotech-aktie-aus-deutschland-hat-niemand-auf-dem-schirm-20352622.html
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Solarfuture Solarfuture 3 months ago
Thank you too for sharing your information!
Yes, I'm from Germany...
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FACT-MASTER FACT-MASTER 3 months ago
Agree, it also shows that the CD4/8 combination significantly improves efficacy. ( same thing over TCRX)

T cell-engaging bispecifics are designed to redirect T cells to cancer antigens. IMA401 is a next-gen T cell engaging receptor (TCER®) combining a high-affinity TCR domain against an HLA-A*02:01-presented MAGEA4/8 peptide, a low-affinity T cell-recruiting antibody and an Fc part for half-life extension. The target peptide exhibits a >5-fold higher density compared to the MAGEA4-derived peptide targeted by other bispecifics or cell therapies.

Again, I'm not 100% sure but i'm thinking there should be a press release over the next couple of days detailing the ESMO abstract in more layman's terms

I have assumed for a while that you live in Germany ( or Europe somewhere) and thanks for sharing the information on the production facility.

I'm in North America and just doing some Sunday afternoon research on a beautiful day here
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Solarfuture Solarfuture 3 months ago
That could give a great push in PPS...Not Long ago they finished a big production facility in Germany...together that all makes sence
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Solarfuture Solarfuture 3 months ago
I agree. I would say 80 %. But this would mean a fantastic result!
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FACT-MASTER FACT-MASTER 3 months ago
And look at the broad spectrum of cancer types that were part of this trial!!
Possible breakthrough potential here!!, imo

" Among these were pts with ovarian cancer, sqNSCLC, gastric cancer, HNSCC, melanoma, and neuroendocrine carcinoma."

https://cslide.ctimeetingtech.com/esmo2024/attendee/confcal/show/session/232#presentation-abstract-895832222418
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FACT-MASTER FACT-MASTER 3 months ago
I'm not 100% sure, however wouldn't this be an 80% ORR ( objective response rate) 20/25 patients?

"55% (11/20) of efficacy-evaluable pts treated in the escalation phase, including initial low MABEL-based starting DLs, achieved disease control (SD/PR). Among these were pts with ovarian cancer, sqNSCLC, gastric cancer, HNSCC, melanoma, and neuroendocrine carcinoma. 45% (9/20) of the pts showed shrinkage of target lesions (median -21.7%), including 3 pts with durable confirmed PRs at 4+, 10+ and 11+ months after first infusion."

https://cslide.ctimeetingtech.com/esmo2024/attendee/confcal/show/session/232#presentation-abstract-895832222418
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FACT-MASTER FACT-MASTER 3 months ago
IMTX: Presentation on Phase 1a/1b IMA401 tomorrow at ESMO/24

Remember IMA401 is in collaboration with BMS ( https://immatics.com/our-pipeline/)

ESMO Abstract

https://cslide.ctimeetingtech.com/esmo2024/attendee/confcal/show/session/232#presentation-abstract-895832222418

Abstract
Background
T cell-engaging bispecifics are designed to redirect T cells to cancer antigens. IMA401 is a next-gen T cell engaging receptor (TCER®) combining a high-affinity TCR domain against an HLA-A*02:01-presented MAGEA4/8 peptide, a low-affinity T cell-recruiting antibody and an Fc part for half-life extension. The target peptide exhibits a >5-fold higher density compared to the MAGEA4-derived peptide targeted by other bispecifics or cell therapies.

Methods
This ongoing Phase 1a/1b first-in-human clinical trial evaluates IMA401 in patients (pts) with recurrent/refractory solid tumors. HLA-A*02:01+ and MAGEA4/8+ pts received initially QW then Q2W iv. IMA401 infusions. Primary objectives: MTD and/or RP2D. Secondary objectives: safety, tolerability, PK, initial anti-tumor activity.

Results
As of April 1, 2024, 25 heavily pretreated cancer pts received IMA401 across the first dose levels (DL1-7, 6.6ยตg-2.5mg). IMA401 showed manageable tolerability with most common (≥30%) treatment-related adverse events being transient lymphopenia (G1-4) and CRS (G1/2). High-grade (G3/4) neutropenia observed at DL7 did not reoccur after the introduction of dexamethasone pre-treatment. MTD/RP2D was not reached and dose escalation is ongoing. Median terminal half-life was 15.0 days. 55% (11/20) of efficacy-evaluable pts treated in the escalation phase, including initial low MABEL-based starting DLs, achieved disease control (SD/PR). Among these were pts with ovarian cancer, sqNSCLC, gastric cancer, HNSCC, melanoma, and neuroendocrine carcinoma. 45% (9/20) of the pts showed shrinkage of target lesions (median -21.7%), including 3 pts with durable confirmed PRs at 4+, 10+ and 11+ months after first infusion.

Conclusions
IMA401 was well tolerated and its single-agent anti-tumor activity was demonstrated by durable objective responses and disease control. The prolonged half-life prompted a switch to treatment every 2 weeks already during dose escalation. The data of this ongoing Phase 1 dose escalation trial provide first clinical PoC for the next-gen half-life extended TCER® format and its potential in multiple solid tumors.

Clinical trial identification
NCT05359445.

Legal entity responsible for the study
Immatics Biotechnologies GmbH.
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Solarfuture Solarfuture 3 months ago
Volume rises....
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Solarfuture Solarfuture 3 months ago
Yes,I mean too with RMAT...
It's very interesting they announce that something will be announced. This only makes sense If something positive will be presented IMO...
This here can become very interesting very soon...Good data can also wake up "Big Pharma" very soon...I believe good times already in 2024...
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FACT-MASTER FACT-MASTER 3 months ago
Agree.
Another presentation just announced for the 21st International Congress of the Society for Melanoma Research on October 11/24.
Looks like a possible update coming on IMA203. If i recall correctly IMTX had RMAT designation for IMA203 - this could get very interesting, imo

https://finance.yahoo.com/news/immatics-announces-upcoming-oral-presentation-110000681.html

Houston, Texas and Tuebingen, Germany, September 06, 2024 โ€“ Immatics N.V. (NASDAQ: IMTX, โ€œImmaticsโ€ or the โ€œCompanyโ€), a clinical-stage biopharmaceutical company active in the discovery and development of T cell-redirecting cancer immunotherapies, today announced that updated clinical data on its lead cell therapy candidate, ACTengine® IMA203 targeting PRAME, will be presented at the 21st International Congress of the Society for Melanoma Research.

Oral presentation

Date / Time: October 11, 2024 / 8:00 โ€“ 8:20 am Central Daylight Time
Session: Plenary Session 1 โ€“ Developmental Immunotherapy (Cellular Immunotherapy, Vaccines, and New Checkpoints)
Title: ACTengine IMA203 TCR-T targeting PRAME in PD1-refractory metastatic melanoma โ€“ Clinical Update
Presenter: Martin Wermke, M.D. (University Hospital Dresden, Germany)

About IMA203

ACTengine® IMA203 T cells is an autologous T cell product with a genetically modified, pairing-enhanced TCR directed against an HLA-A*02-presented peptide derived from preferentially expressed antigen in melanoma (PRAME). This peptide is frequently expressed in a large variety of solid cancers, thereby supporting the programโ€™s potential to address a broad cancer patient population. Immaticsโ€™ PRAME peptide is present at a high copy number per tumor cell and is homogeneously and specifically expressed in tumor tissue. The peptide has been identified and characterized by Immaticsโ€™ proprietary mass spectrometry-based target discovery platform, XPRESIDENT®. Through its proprietary TCR discovery and engineering platform XCEPTOR®, Immatics has generated a highly specific T cell receptor (TCR) against this target for its TCR-based cell therapy approach, ACTengine® IMA203.

ACTengine® IMA203 TCR-T is currently being evaluated in a Phase 1 trial as IMA203 monotherapy, and as a second-generation IMA203CD8 (GEN2) monotherapy, where IMA203-engineered T cells are co-transduced with a CD8aรŸ co-receptor, thereby leveraging the power of both CD4+ and CD8+ T cells. As previously reported, IMA203 in combination with an immune checkpoint inhibitor has been deprioritized.
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Solarfuture Solarfuture 3 months ago
Very interesting...even I don't understand everything...but the second half of the year seems to become promising...
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FACT-MASTER FACT-MASTER 3 months ago
IMTX: Recent video

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FACT-MASTER FACT-MASTER 4 months ago
IMTX: Immatics Appoints Alise Reicin to Board of Directors

https://finance.yahoo.com/news/immatics-appoints-alise-reicin-board-110000822.html

(looks like a high profile addition to the BOD, imo)
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Solarfuture Solarfuture 5 months ago
Agree, else they would not file a news for this...
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