RefleXion and Limbus AI Announce Technology Integration to Expedite Cancer Treatment Planning
March 28 2024 - 9:01AM
Business Wire
Agreement improves radiotherapy planning
workflow and the patient experience
RefleXion Medical, Inc., a therapeutic oncology company, and
Limbus AI, Inc., a provider of software solutions for cancer
radiation therapy, today announced a licensing agreement to
incorporate Limbus’ automated contouring software, Limbus Contour,
into the RefleXion® X1 radiotherapy treatment planning system. This
integration will reduce the most significant bottleneck in the
patient treatment planning process, which involves delineating the
tumor target from surrounding critical organs and other healthy
tissue.
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Unedited head-and-neck image generated by
the RefleXion® X1 displays excellent contrast and detail
resolution, and near-perfect Limbus AI contours visible on several
structures. (Photo: Business Wire)
“Contouring is one of the most time-consuming tasks in
radiotherapy planning, and often contributes to treatment delays,”
said Sam Mazin, Ph.D., co-founder and chief technology officer at
RefleXion. “We have found Limbus Contour’s AI-driven solution to be
a technology leader in speed, accuracy and versatility. Depending
on the complexity of the treatment plan, we expect contouring time
reductions of up to 80%1, thus ensuring that patients receive
timely treatment.
“Furthermore, this sets the stage for adapting the treatment
plan immediately prior to delivery to leverage the unique and rich
anatomic and biologic information produced by the X1 in
image-guided and SCINTIX procedures,” continued Mazin.
Radiotherapy treatment planning begins with the patient
undergoing computed tomography (CT) imaging of the tumor target.
Clinicians then manually outline or “contour” both the treatment
area and the nearby organs (known as organs at risk or OARs) where
irradiation should be minimized. This manual process is
time-consuming and often suffers from variability between
clinicians, which can lead to inconsistencies in the quality of the
treatment plan and limit its effectiveness. Limbus Contour employs
clinically validated, deep-learning segmentation algorithms with a
high level of accuracy to reduce human error and help ensure
precise radiation delivery to target areas and avoidance of
OARs.
“The performance of Limbus Contour software relies on the
quality of the CT image,” said Karl Otto, Ph.D., CEO at Limbus AI.
“X1 images demonstrate high resolution, exceptional contrast, and
minimal noise and motion artifacts. This should enhance precision
in distinguishing adjacent structures and yield consistent,
reliable contouring results, ensuring patients receive the highest
quality care possible.”
The X1 with SCINTIX® technology is a dual-treatment
modality radiotherapy platform that can treat patients with
FDA-cleared indicated solid tumors of any stage. Both treatment
modalities, biologic and anatomic, will benefit from the
efficiencies of Limbus Contour integration.
About RefleXion Medical
RefleXion is a privately held therapeutic oncology company
located in Hayward, Calif., commercializing SCINTIX biology-guided
radiotherapy, a novel therapy that uses a single radiotracer
injection to transform cancer cells into real-time biological
beacons to control external-beam radiotherapy delivery to single or
multiple tumors. SCINTIX therapy is indicated for use in FDG-guided
treatment of lung and bone tumors arising from either primary lung
and bone cancers or resulting from metastases by other primary
cancers. In addition to SCINTIX therapy, the RefleXion X1 is also
FDA-cleared for conventional image-guided external-beam
radiotherapy for solid tumors located anywhere in the body.
About Limbus AI
Limbus AI is dedicated to improving cancer care through the
development of state-of-the-art software. The company’s machine
learning-based products improve efficiency and clinical workflows
in cancer radiation treatment planning. Limbus AI specializes in
the creation of artificial intelligence (AI)-driven automatic
contouring algorithms performed entirely on customers' existing
clinical workstations within the security of their own local
network. These unique software solutions enable clinicians to
create more accurate treatment plans more quickly, allowing for the
delivery of more precise treatments throughout the course of care.
Limbus AI is headquartered in Regina, Saskatchewan, Canada.
1Hoque SMH, Pirrone G, Matrone F, Donofrio A, Fanetti G, Caroli
A, Rista RS, Bortolus R, Avanzo M, Drigo A, et al. Clinical Use of
a Commercial Artificial Intelligence-Based Software for
Autocontouring in Radiation Therapy: Geometric Performance and
Dosimetric Impact. Cancers. 2023; 15(24):5735.
https://doi.org/10.3390/cancers15245735
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version on businesswire.com: https://www.businesswire.com/news/home/20240327446154/en/
RefleXion Contact: Amy Cook acook@reflexion.com +1
925-222-5094
Limbus Contact: David Talton dave@limbus.ai +1
215-431-5679