New Hope for Melanoma Patients -- Update
May 18 2016 - 10:27PM
Dow Jones News
By Peter Loftus
A new study reinforces the potential of a new class of expensive
immune-boosting drugs to prolong the lives of people with a deadly
form of skin cancer.
An estimated 40% of 655 people who took Merck & Co.'s
Keytruda in a clinical trial to treat advanced melanoma were still
alive three years after starting treatment, the Merck-funded study
shows, according to results released online by the American Society
of Clinical Oncology. Researchers said three-year survival rates
for older melanoma treatments were about 10% to 20%. The median
overall survival among patients in the study was about two years.
The study continues.
Keytruda and similar new "immunotherapy" drugs are designed to
harness the immune system to destroy cancerous cells. For certain
types of tumors, particularly melanoma, the new drugs have extended
average patient survival beyond what older drugs could achieve.
In April, researchers said that about 34% of melanoma patients
who took Bristol-Myers Squibb Co.'s Opdivo were still alive five
years after starting treatment. In comparison, the average
five-year survival rate for all patients with advanced melanoma has
been about 15% to 20%, according to the American Cancer
Society.
"Patients with advanced melanoma are often very reasonably
scared about the diagnosis, based on reading old statistics about
long-term survival probabilities," said Michael Postow, a medical
oncologist at Memorial Sloan Kettering Cancer Center in New York
who wasn't involved in the new survival analysis but has been
involved in other Keytruda studies. "All of these statistics are
now being rewritten in a favorable way with these new drugs."
Keytruda is the drug that former U.S. President Jimmy Carter
said last year he received to treat melanoma that had spread to
other parts of his body. In December, Mr. Carter said recent
imaging scans had shown no signs of cancer. A spokeswoman for Mr.
Carter's charitable organization, the Carter Center, said Wednesday
she didn't have an update on his condition.
Use of the new immunotherapy drugs is expanding to treat other
types of tumors such as lung cancer. On Wednesday, the U.S. Food
and Drug Administration approved a new Roche Holding AG drug,
Tecentriq, to treat bladder cancer. And on Tuesday, the FDA
approved Bristol's Opdivo to treat Hodgkin lymphoma.
The benefits of the new immunotherapy drugs come at a price:
Keytruda and Opdivo each cost more than $12,500 a month for the
average patient. Roche said Tecentriq will cost about $12,500 a
month per patient. Researchers still haven't determined how long
patients should take the drugs.
Results of the Keytruda study and other cancer trials will be
presented in June at ASCO's annual meeting in Chicago.
Ron Winslow contributed to this article.
Write to Peter Loftus at peter.loftus@wsj.com
Corrections & Amplifications
An earlier version of this article was illustrated with a
photograph of a logo that was not that of Merck & Co.
(END) Dow Jones Newswires
May 18, 2016 22:12 ET (02:12 GMT)
Copyright (c) 2016 Dow Jones & Company, Inc.
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