By Robin Sidel And Joann S. Lublin 

The president of American Express Co. collapsed and died on the way home from a business trip Friday morning, sending shock waves through the New York company where he had worked since he was a college student.

Edward Gilligan, 55 years old, was traveling on a corporate plane returning to New York from a trip to Japan when he fell ill, the company said. Other executives were also on the plane, a spokesman said.

Mr. Gilligan was viewed as a likely successor to Kenneth Chenault, the company's longtime chief executive. Mr. Chenault, who will be 64 years old next week, wasn't on the plane.

Mr. Gilligan was named president of AmEx in 2013, having served in a number of key roles at the company, and was viewed as a strong leader internally and by investors.

"His contributions have left an indelible imprint on practically every area of our business, from commercial card and travel to international, consumer, small business, merchant services, network services and, most recently, the group forging our digital partnerships and driving payment innovations," Mr. Chenault said in a letter to the staff.

Mr. Gilligan's death leaves the company without a clear successor at a time when it is facing a number of difficulties. Its revenue has repeatedly fallen below its internal goals despite strong credit trends.

The company recently announced that it would end a 16-year relationship with Costco Wholesale Corp. in which its plastic was the only credit-card accepted at the warehouse club. AmEx also lost a high-profile antitrust lawsuit that was filed by the Justice Department.

"In our view, his name was at the top of any succession planning and his absence obviously hurts," wrote Sanjay Sakhrani, an analyst at Keefe, Bruyette & Woods, in a note to clients. Mr. Sakhrani also said "there is a solid bench of executives at the company."

AmEx shares dropped slightly after the news of Mr. Gilligan's death was announced, closing down 0.5% at $79.72. The company's shares are down more than 12% over the past year.

American Express faces an unusual conundrum as boards typically plan ahead for the sudden demise of their leader--rather than the heir apparent, one succession specialist said.

Directors likely will quickly identify other potential Chenault successors and try "to put them on an accelerated development path," predicted Jeffrey Cohn, a CEO succession expert.

"The problem is there is no such thing as accelerated development" for a CEO role, he added. "It takes time."

Mr. Chenault, CEO since 2001, hasn't given any indication that he plans to step down. But in the absence of a clear heir apparent, Mr. Chenault's retirement "just got delayed by a couple of years," Mr. Cohn predicted.

Other top executives have left AmEx in recent years, including Jud Linville, who now runs the credit-card division of Citigroup Inc., and Dan Schulman, who is the chief executive of PayPal, which is being spun off by eBay Inc.

The unexpected CEO succession crisis at American Express underscores the fact that "you can't have all your eggs in one basket," said Paul Winum, head of the board and CEO services practice at RHR International, a leadership development firm. "A good succession plan has to have multiple candidates."

Mr. Gilligan started at AmEx in a temporary accounting position in 1980 while he was a student at New York University, where he received an undergraduate degree in economics and management.

Mr. Gilligan spent significant amounts of time working in AmEx's key businesses, including its commercial card division. He also worked for the company in London, where he led its international consumer-card business.

"Ed was a terrific friend whom I've always held in the highest regard. He will be greatly missed," said Gordon Smith, a former AmEx executive who now runs the consumer-banking business at J.P. Morgan Chase & Co. The pair worked together at AmEx and also lived in the same New Jersey town for a number of years.

Mr. Gilligan was on the board of the Lincoln Center for the Performing Arts in New York. He was also on the board of trustees of New York's Xaverian High School, which he graduated in 1977.

Mr. Gilligan is survived by his wife and four children.

"This is deeply painful and frankly unimaginable for all of us who had the great fortune to work with Ed," Mr. Chenault said in a statement. "He was a proud husband and father, and his love for his family was evident in all that he did."

Write to Robin Sidel at robin.sidel@wsj.com and Joann S. Lublin at joann.lublin@wsj.com

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