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Cogent Biosciences Inc

Cogent Biosciences Inc (COGT)

9.27
0.13
(1.42%)
Closed July 14 4:00PM
9.27
0.03
(0.32%)
After Hours: 6:56PM

Professional-Grade Tools, for Individual Investors.

Key stats and details

Current Price
9.27
Bid
8.20
Ask
9.50
Volume
551,369
9.10 Day's Range 9.41
3.67 52 Week Range 13.36
Market Cap
Previous Close
9.14
Open
9.32
Last Trade
1
@
9.47
Last Trade Time
Financial Volume
$ 5,099,593
VWAP
9.249
Average Volume (3m)
1,316,736
Shares Outstanding
95,613,396
Dividend Yield
-
PE Ratio
-1.17
Earnings Per Share (EPS)
-2.01
Revenue
-
Net Profit
-192.41M

About Cogent Biosciences Inc

Cogent Biosciences Inc a biotechnology company focused on developing precision therapies for genetically defined diseases. It designs rational precision therapies that treat the underlying cause of disease and improve the lives of patients. Its program CGT9486, is a selective tyrosine kinase inhibit... Cogent Biosciences Inc a biotechnology company focused on developing precision therapies for genetically defined diseases. It designs rational precision therapies that treat the underlying cause of disease and improve the lives of patients. Its program CGT9486, is a selective tyrosine kinase inhibitor designed to potently inhibit the KIT D816V mutation as well as other mutations in KIT exon 17. In the vast majority of cases, KIT D816V is responsible for driving Systemic Mastocytosis (SM), a serious disease caused by unchecked proliferation of mast cells. Exon 17 mutations are also found in patients with advanced gastrointestinal stromal tumors (GIST), a type of cancer with strong dependence on oncogenic KIT signaling. Show more

Sector
Pharmaceutical Preparations
Industry
Pharmaceutical Preparations
Website
Headquarters
Dover, Delaware, USA
Founded
1970
Cogent Biosciences Inc is listed in the Pharmaceutical Preparations sector of the NASDAQ with ticker COGT. The last closing price for Cogent Biosciences was $9.14. Over the last year, Cogent Biosciences shares have traded in a share price range of $ 3.67 to $ 13.36.

Cogent Biosciences currently has 95,613,396 shares outstanding. The market capitalization of Cogent Biosciences is $873.91 million. Cogent Biosciences has a price to earnings ratio (PE ratio) of -1.17.

COGT Latest News

Cogent Biosciences Announces Positive FDA Meeting and Alignment on MS2D2, a Novel Patient Reported Outcome Measure for the SUMMIT trial

WALTHAM, Mass. and BOULDER, Colo., June 27, 2024 (GLOBE NEWSWIRE) -- Cogent Biosciences, Inc. (Nasdaq: COGT), a biotechnology company focused on developing precision therapies for genetically...

Cogent Biosciences Announces Additional Clinical Data from Part 1 of its Ongoing SUMMIT Trial Evaluating Bezuclastinib in Patients with NonAdvanced Systemic Mastocytosis (NonAdvSM)

Patients treated with 100 mg bezuclastinib showed substantial reduction in their most severe symptoms and mast cell reactions Reductions were shown in all individual MS2D2 symptoms across domains...

PeriodChangeChange %OpenHighLowAvg. Daily VolVWAP
10.9110.88516746418.369.418.026521788.82622436CS
40.394.391891891898.889.417.8414037378.61430339CS
122.6940.88145896666.589.415.8813167367.99613935CS
263.972.6256983245.3710.264.2817685447.26196084CS
52-3.37-26.661392405112.6413.363.6714705667.44353699CS
1562.434.93449781666.8718.073.6710531199.00796147CS
2607.07321.3636363642.218.072.29255198.95443872CS

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COGT Discussion

View Posts
Monksdream Monksdream 1 week ago
COGT under $10
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Monksdream Monksdream 3 months ago
COGT under $10
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Invest-in-America Invest-in-America 5 months ago
COGT: I CONCUR with your assessment, Sir, by 1,000%!!! (And, instead of just a "Bullish", or a "Bearish" click-box for any post, iHub should also have a "BULLSHIT" box to click below any post to a board!!!)
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javier1973 javier1973 5 months ago
Great bull shhhh
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Invest-in-America Invest-in-America 5 months ago
COGT: Great news, but then the price stays RED???
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gail gail 7 months ago
and off she goes.
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gail gail 7 months ago
nice a/h action. im lonely, such a quiet board. lol
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gail gail 7 months ago
wow, here we goooo!!!!
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gail gail 7 months ago
grabbed some on the dip today.
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Pedro2004 Pedro2004 2 years ago
Too much manipulation today. And someone has a lot of shares to unload.
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Pedro2004 Pedro2004 2 years ago
The trading on this today is crazy.
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crudeoil24 crudeoil24 2 years ago
COGT up 60% @ 7.97
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crudeoil24 crudeoil24 2 years ago
UPDATE: Cogent Biosciences Says 'All patients treated with bezuclastinib achieved ≥50% reduction in serum tryptase, with a median reduction of 89%, regardless of prior KIT D816V inhibitor treatment'
7:01 am ET June 10, 2022 (Benzinga) Print
All patients treated with bezuclastinib achieved ≥50% reduction in serum tryptase, with a median reduction of 89%, regardless of prior KIT D816V inhibitor treatment

All bone marrow biopsy-assessed patients achieved ≥50% bone marrow mast cell reduction and decreases in blood KIT D816V variant allele fraction (VAF)

Bezuclastinib demonstrates favorable initial safety and tolerability profile with no reported periorbital or peripheral edema, cognitive effects or intracranial bleeding events

Cogent to host investor conference call and webcast today at 8:00 a.m. ET?

CAMBRIDGE, Mass. and BOULDER, Colo., June 10, 2022 (GLOBE NEWSWIRE) -- Cogent Biosciences, Inc. (NASDAQ:COGT), a biotechnology company focused on developing precision therapies for genetically defined diseases, today announced positive initial data from its ongoing Phase 2 APEX clinical trial evaluating the selective KIT D816V inhibitor bezuclastinib in patients with advanced systemic mastocytosis (AdvSM). The data are being presented today in a poster presentation at the 2022 European Hematology Association (EHA) Congress in Vienna, Austria.

"Advanced systemic mastocytosis is a severe, debilitating hematologic disorder and physicians and patients remain in search of more effective and better tolerated treatment options to fight this disease," said Daniel DeAngelo, M.D., Ph.D., Chief of the Division of Leukemia at the Dana-Farber Cancer Institute and APEX clinical trial investigator. "I am very impressed with the early, encouraging results presented today from the APEX study. If results like these can be shown in a larger set of patients with AdvSM, I believe bezuclastinib has the potential to help us take a big step forward in treating systemic mastocytosis patients."

"We are very excited to present initial clinical data from the APEX study of bezuclastinib in advanced systemic mastocytosis," said Andrew Robbins, Chief Executive Officer at Cogent Biosciences. "These results reinforce the hypothesis that a potent, selective KIT D816V inhibitor with limited CNS penetration has the potential to provide meaningful clinical activity to all systemic mastocytosis patients, without the tolerability challenges seen with other available treatment options. Based on these results, we expect to accelerate our timelines and investment and look forward to providing another APEX clinical update by the end of 2022, and to presenting SUMMIT clinical data in non-advanced systemic mastocytosis (NonAdvSM) patients in the first half of 2023."

Data from Ongoing Phase 2 APEX Clinical Trial

APEX is a global, open-label, multi-center, two-part Phase 2 clinical trial in patients with AdvSM evaluating the safety, efficacy, pharmacokinetic, and pharmacodynamic profiles of bezuclastinib. As of the data cutoff date of May 24, 2022, 11 patients had been treated in Part 1 at one of four dose levels (50 mg BID, 100 mg BID, 200 mg BID or 400 mg QD). The median age of patients at study entry was 70 years (ranging from 48-87 years). Patients were enrolled with the following sub-types: two patients with aggressive systemic mastocytosis (ASM), eight patients with systemic mastocytosis with associated hematologic neoplasm (SM-AHN), and one patient with mast cell leukemia (MCL). Two patients had received prior avapritinib and midostaurin treatment.

Initial Safety Data?

As of the cutoff date, May 24, 2022, bezuclastinib was generally well-tolerated at all doses. The majority of adverse events were Grade 1/2 and seen in no more than one patient with one serious adverse event and no Grade 4 events reported. Grade 3 events reported as at least possibly related were anemia (1 patient), neutropenia (1 patient) and hypersensitivity/mediator flare (1 patient). There were no reported cases of periorbital/peripheral edema, cognitive effects or intracranial bleeding events, which have been associated with other KIT inhibitors. As of the cutoff date, all patients remained on study. Subsequently, one SM-AHN patient with chronic myelomonocytic leukemia (CMML) transformed to acute myeloid leukemia (AML) and discontinued participation in the trial.

Initial Clinical Activity Data

As of the data cutoff date of May 24, 2022, all 11 patients treated were evaluated for signs of clinical activity. Eight of 11 patients had been treated for at least two cycles, had available data from bone marrow biopsy, and were evaluated for additional endpoints Cycle 3 Day 1 (C3D1) evaluable.

11/11 patients achieved ≥50% reduction in serum tryptase levels by central assessment
89% median reduction in serum tryptase
Six of these patients achieved reduction to <20 ng/mL
8/8 patients (C3D1 evaluable) achieved ≥50% reduction in bone marrow mast cells by central review
Six of these patients achieved complete clearance of bone marrow mast cell aggregates
8/8 patients (C3D1 evaluable) demonstrated decreases in KIT D816V variant allele fraction (VAF) by droplet digital polymerase chain reaction (ddPCR)
All patients remained on treatment with treatment duration ranging from 0.5 - 4.8 months

Two patients enrolled had previously received and discontinued avapritinib for toxicity reasons (intracranial hemorrhage, thrombocytopenia). Both patients have demonstrated clinical outcomes consistent with the avapritinib-naïve patients, including similar magnitude reductions in serum tryptase.

Bezuclastinib Clinical Development?

Based on the favorable initial safety and tolerability profile and clinical activity observed to date in the Phase 2 APEX clinical trial with bezuclastinib for AdvSM,?Cogent?will continue enrolling patients in Part 1 of APEX to determine a recommended dose for use in Part 2 of the trial. A pre-planned interim analysis is scheduled once approximately 28 patients have received at least two cycles of study treatment in Part 1. Cogent plans to present additional data from APEX by the end of 2022. In addition,?Cogent continues to actively enroll?patients in SUMMIT, a Phase 2 clinical trial with bezuclastinib for NonAdvSM, and PEAK, a registrational randomized, open-label, global, Phase 3 clinical trial in patients with imatinib-resistant Gastrointestinal Stromal Tumors (GIST).?Cogent plans to present initial data from SUMMIT and lead-in data from PEAK in the first half 2023.

Conference Call Information & EHA poster

Cogent will host a webcast today at 8:00 am ET to discuss today's APEX results. The webcast will be accessible through the Investors and Media section of Cogent's website at https://investors.cogentbio.com/events. Following the live webcast, an archived replay will also be available.

Dial-in Number

U.S./Canada Dial-in Number: 844-686-3753

International Dial-in Number: 704-753-0395

Conference ID: 2951969

COGT
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murocman murocman 2 years ago
Surprised no posts here, especially with a catalyst imminent!

GLTA,

Murocman
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