Waters and NIBRT Researchers Generate Reference Library for Released N-Glycans Labeled with RapiFluor-MS
August 23 2016 - 2:34PM
Business Wire
New RapiFluor-MS Glycan GU Scientific Library
enables automated data analysis of glycoproteins
Researchers at Waters Corporation (NYSE: WAT) and Ireland’s
National Institute for Bioprocessing Research and Training (NIBRT)
have created a new integrated database called RapiFluor-MS™ (RFMS)
Glycan GU Scientific Library that enables automated data analysis
of N-linked glycans using the Waters® Glycan Application Solution
with UNIFI®.
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GlycoBase-derived Glycan GU databases
supporting UPLC HILIC and HILIC-MS analysis of both 2-AB and
RapiFluor-MS labeled glycans are now available from Waters as
integrated scientific libraries within UNIFI Software. Combined
with the UNIFI glycan analysis workflows, these libraries automate
the analysis of glycoproteins, including the determination of
glycan GU calibrated retention times and assignment of glycan
structures within those profiles. A typical system configuration
includes the Waters ACQUITY UPLC® H-Class or H-Class BioSystem, the
Xevo® G2-XS QTof Mass Spectrometer, GlycoWorks sample preparation
kits and standards, and Waters HILIC columns for glycoproteins.
(Photo: Business Wire)
This new library will be made available as an integrated
database within the Waters UNIFI Scientific Information System and
features UPLC® HILIC chromatographic retention time data for 177
N-linked glycan structures frequently associated with
biotherapeutic proteins. After labeling the released N-linked
glycans with the Waters GlycoWorks™ RapiFluor-MS N-Glycan Kit and
performing UPLC-MS analyses, their retention times are converted to
Glucose Units (GU), a capability that is especially critical to
global organizations that run on different instruments.
“By combining an experimentally derived reference library with
the ground-breaking sample labeling technology for characterizing
N-linked glycans, scientists are now able to automatically and
confidently analyze these important analytes at new levels of
speed, sensitivity, and simplicity. The RapiFluor-MS Glycan GU
Scientific Library is an important and logical extension to the
RapiFluor-MS Labeling Kit," commented Ying Qing Yu, Ph.D., Senior
Science Manager at Waters Corporation. “Driven by customer demand,
the RFMS Glycan GU Scientific Library automates data analysis and
provides scientists with more confidence in their assessment of the
critical quality attributes of glycosylated biotherapeutics.”
The RFMS Glycan GU Scientific Library was jointly generated and
confirmed by UPLC-MS and glycosidase arrays through a collaborative
effort between Waters and Professor Pauline Rudd’s GlycoScience
research team at NIBRT. Professor Rudd said, “We are delighted to
announce the launch of the new RapiFluor-MS Glycan GU Scientific
Library. We have partnered with Waters over many years to address
key issues in the characterization of glycans for the
biopharmaceutical research and industry communities. This new
release will provide new levels of structural information in a
rapid, sensitive, and straightforward manner.”
About NIBRT (www.nibrt.ie)National Institute of
Bioprocessing Research and Training, NIBRT, is a world-class
institute, delivering training and research solutions for the
global biopharmaceutical industry. Partnering with all higher
education institutes as well as industry, NIBRTs state of the art
training facility supports international best practice in biologics
operations.
About Waters Corporation (www.waters.com)Waters
Corporation (NYSE:WAT) develops and manufactures advanced
analytical and material science technologies for laboratory
dependent organizations. For more than 50 years, the company has
pioneered a connected portfolio of separations science, laboratory
information management, mass spectrometry, and thermal analysis
systems.
Waters, The Science of What’s Possible, UPLC, and UNIFI and are
registered trademarks of Waters Corporation. GlycoWorks and
RapiFluor-MS are trademarks of Waters Corporation. All other
trademarks are property of their respective owners.
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version on businesswire.com: http://www.businesswire.com/news/home/20160823006203/en/
Waters CorporationKaren Haas, +1
508-482-3363Karen_haas@waters.comorNIBRTKillian O’Driscoll,
01-2158100killian.odriscoll@nibrt.ie
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