LONDON-- Standard Chartered PLC Chief Executive Peter Sands on Thursday said he will step down in June and be replaced by former J.P. Morgan Chase & Co. executive Bill Winters, after months of disquiet from shareholders and executives over the bank's leadership.

The London-based, Asia-focused lender said Chairman John Peace will step down in 2016, and that it will firm up its board with two new independent directors while three veterans will depart.

Mr. Sands said "now is the right moment" to hand over to Mr. Winters. "I am delighted that a banker of Bill's calibre will be leading the group through the next phase of development," he said.

Mr. Winters, who set up asset management firm Renshaw Bay after leaving J.P. Morgan in 2009, called Standard Chartered "a special bank" that he looks forward to helping bring to its full potential. The 53-year-old American was co-CEO of J.P. Morgan's investment bank during a 26-year career at the U.S. lender. He also served on the U.K. Independent Commission on Banking, which played a key role in reforming Britain's banking sector after the financial crisis.

While Mr. Winters has been mentioned in the past as a CEO candidate for other U.K. banks, his appointment Thursday is a surprise. Despite his impressive resume, he has little direct experience in Standard Chartered's core emerging markets. Mr. Peace said Mr. Winters "brings substantial financial experience from leading a successful global business and has an exceptional understanding of the global regulatory and conduct environment."

The long-awaited shake-up at the troubled bank comes after Mr. Sands and Mr. Peace were privately pressed by some executives and shareholders to resign, according to people familiar with the matter.

Standard Chartered for a decade rode a wave of growth in Asian lending markets. But a slowdown in some of its key markets and rising regulatory costs have weighed on its results and led some analysts to question its strategy and capital adequacy.

Mr. Sands for months has said he wasn't going anywhere. He laid out plans in January to shed thousands of jobs in Standard Chartered's retail bank and shut its stock-trading business, but the plans were regarded by many as insufficient to address the bank's broader problems.

Write to Margot Patrick at margot.patrick@wsj.com

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