By Robin Sidel And Joann S. Lublin 

The president of American Express Co., who was viewed as a likely successor to Chief Executive Kenneth Chenault, collapsed and died on the way home from a business trip Friday. His death sent shock waves through the New York company where he had worked since he was a college student.

Edward Gilligan, 55 years old, was traveling on a corporate plane returning to New York from a trip to Japan when he fell ill, the company said. Other executives also were on the plane, a spokesman said.

Mr. Chenault, the company's longtime CEO who will be 64 years old next week, wasn't on the plane.

Mr. Gilligan was named president of AmEx in 2013, having served in a number of key roles at the company, and was viewed as a strong leader internally and by investors.

"His contributions have left an indelible imprint on practically every area of our business, from commercial card and travel to international, consumer, small business, merchant services, network services and, most recently, the group forging our digital partnerships and driving payment innovations," Mr. Chenault said in a letter to staff.

Mr. Gilligan's death leaves the company without a clear successor at a time when it is facing a number of difficulties. Its revenue has repeatedly fallen below its internal goals despite strong credit trends.

The company recently announced that it would end a 16-year relationship with Costco Wholesale Corp. in which its plastic was the only credit card accepted at the warehouse club. AmEx also lost an antitrust lawsuit that was filed by the Justice Department.

"In our view, his name was at the top of any succession planning and his absence obviously hurts," wrote Sanjay Sakhrani, an analyst at Keefe, Bruyette & Woods, in a note to clients. Mr. Sakhrani also said "there is a solid bench of executives at the company."

AmEx's shares dropped slightly after news of Mr. Gilligan's death was announced and closed down 0.5%, at $79.72. The company's shares have declined 13% over the past year.

American Express faces an unusual conundrum as boards typically plan ahead for the sudden demise of their leader, rather than the heir apparent, one succession specialist said.

Directors likely will quickly identify other potential Chenault successors and try "to put them on an accelerated development path," predicted Jeffrey Cohn, who advises on CEO succession. "The problem is there is no such thing as accelerated development" for a CEO role, he said. "It takes time."

Mr. Chenault, CEO since 2001, hasn't given any indication that he plans to step down. But in the absence of a clear heir apparent, Mr. Chenault's retirement "just got delayed by a couple of years," Mr. Cohn predicted.

Other top executives have left AmEx in recent years, including Jud Linville, who now runs the credit-card division of Citigroup Inc., and Dan Schulman, who is the CEO of PayPal, which is being spun off by eBay Inc.

Top executives at AmEx include John D. Hayes, chief marketing officer since 2003; Joshua Silverman, president of consumer products and a former eBay executive; Steve Squeri, who runs the corporate business and has been with the company for more than a decade; and Jeffrey Campbell, who was hired from McKesson Corp. in 2013 as chief financial officer.

It isn't clear if any of them would be potential candidates for the top job when Mr. Chenault steps down.

The unexpected CEO succession crisis at American Express underscores the fact that "you can't have all your eggs in one basket," said Paul Winum, head of the board and CEO services practice at RHR International, a leadership development firm. "A good succession plan has to have multiple candidates."

Mr. Gilligan started at AmEx in a temporary accounting position in 1980 while he was a student at New York University, where he received an undergraduate degree in economics and management.

Mr. Gilligan spent significant amounts of time working in AmEx's key businesses, including its commercial-card division. He also worked for the company in London, where he led its international consumer-card business.

"Ed was a terrific friend who I've always held in the highest regard. He will be greatly missed," said Gordon Smith, a former AmEx executive who now runs the consumer-banking business at J.P. Morgan Chase & Co. The pair worked together at AmEx and lived in the same New Jersey town for a number of years.

Mr. Gilligan was on the board of the Lincoln Center for the Performing Arts in New York. He also was on the board of trustees of New York's Xaverian High School, from which he graduated in 1977. Mr. Gilligan is survived by his wife and four children.

"This is deeply painful and frankly unimaginable for all of us who had the great fortune to work with Ed," Mr. Chenault said in a statement. "He was a proud husband and father, and his love for his family was evident in all that he did."

Write to Robin Sidel at robin.sidel@wsj.com and Joann S. Lublin at joann.lublin@wsj.com

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