Agilent Technologies Launches SureGuide CRISPR Libraries for Functional Genomics
October 20 2016 - 11:00AM
Business Wire
SureGuide Offerings Include GeCKO Libraries and Full
Customization for Any CRISPR Screening Experiment
Agilent Technologies Inc. (NYSE: A) today launched a
comprehensive offering of pooled CRISPR libraries for functional
genomics. SureGuide harnesses Agilent’s industry-leading
oligonucleotide synthesis platform to create CRISPR guide
libraries, which are a critical component of the CRISPR/Cas genome
editing system. The flexibility of Agilent’s SureGuide platform
enables CRISPR-based functional screening for any application, from
genome-wide knock-outs (GeCKO) to fully customized, user-designed
libraries.
The introduction of genome engineering tools, based on CRISPR,
has rapidly accelerated research related to functional studies of
complex diseases and drug discovery. Genetic screens using pooled
libraries are typically performed to locate and identify genes that
are involved in cellular response, such as in signaling pathways,
or to discover the function of novel genes. The introduction of
CRISPR-based tools has provided an opportunity to overcome the
limitations of previous technologies used in functional
screening.
As a key component in any CRISPR experiment, guide library
quality and composition can affect all of the downstream segments
of the workflow including screening effort, sequencing cost and
false positive/negative identification. SureGuide offers
high-fidelity CRISPR guides alongside SureVector cloning
technology, which enable an optimal distribution of guides to be
maintained across even the most complex libraries.
SureGuide CRISPR libraries are available in three formats:
Ready-to-package plasmid libraries consist of GeCKO
libraries; target all exons in the human or mouse genome; and have
been validated by researchers studying functional gene interactions
on an -omics scale.
Ready-to-clone custom libraries enable user-defined
custom CRISPR targets in mammalian cells. These custom libraries
can be prepared for delivery with Agilent’s SureVector library
cloning kits, which makes plasmid library generation a simple and
rapid process.
Ready-to-amplify custom libraries enable researchers to
design every aspect of their CRISPR library, allowing the use of
alternative delivery systems, cloning approaches, and the
development of CRISPR libraries targeting any set of genomic
regions in any organism.
“Agilent SureGuide CRISPR Libraries are built on Agilent’s well
known, high-fidelity oligo synthesis platform,” said Herman
Verrelst, Agilent vice president and general manager, Genomics
Solutions Division and Clinical Applications Division. “Our unique
technology allows us to provide researchers with fully customizable
guide libraries at the same exceptional quality as our GeCKO
offerings.”
Verrelst noted that Agilent offers an extensive range of
instrumentation and reagents that can help laboratories get the
best possible results from their CRISPR screens.
“The new libraries represent the first of several planned
products in a CRISPR-focused portfolio, supporting every aspect of
the CRISPR screening workflow all the way through analysis and hit
validation,” he said.
Agilent will host a workshop today at ASHG 2016 in Vancouver
titled: A CRISPR Guide to Superior Custom sgRNA Libraries, where
the SureGuide technology and workflow will be highlighted. In
addition, customers will speak about their novel research
applications using SureGuide CRISPR Libraries.
About Agilent Technologies
Agilent Technologies Inc. (NYSE: A), a global leader in
life sciences, diagnostics and applied chemical markets, is the
premier laboratory partner for a better world. Agilent works with
customers in more than 100 countries, providing instruments,
software, services and consumables for the entire laboratory
workflow. The company generated revenues of $4.04 billion in fiscal
2015 and employs about 12,000 people worldwide. Information about
Agilent is available at www.agilent.com.
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Agilent TechnologiesVictoria Wadsworth-Hansen, +1
408-553-2005victoria.wadsworth-hansen@agilent.com
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