NIH to Study Three Drugs in Treatment of Covid-19 Patients
October 16 2020 - 7:59AM
Dow Jones News
By Thomas M. Burton
WASHINGTON -- The National Institutes of Health is launching a
late-stage clinical trial to determine whether three drugs used for
controlling immune systems could be used to treat respiratory
distress and organ failure in severely ill Covid-19 patients.
The NIH study will evaluate two drugs already on the market,
Johnson & Johnson's Remicade and Bristol-Myers Squibb Co.'s
Orencia, along with an investigational drug called CVC from AbbVie
Inc.
The study will evaluate whether any of the medicines, known as
immune modulators, can control an overreaction of the patient's
systemic Covid-19 inflammatory response.
This phenomenon, known as a "cytokine storm" for the proteins
that trigger the inflammation, can lead to respiratory distress,
multiple organ failure and other severe reactions in hospitalized
patients. Cytokines are part of the body's normal immune reaction,
but one that in this instance has gone haywire.
The study, at sites in the U.S. and Latin America, is expected
to last up to eight months and will enroll about 2,100 patients.
All of the patients will receive the standard-treatment antiviral
drug remdesivir.
Some will also get a placebo, while others will also get one of
the drugs being studied. The study will evaluate whether the study
drugs lower severity of disease, recovery time, death rate and use
of hospital resources.
Write to Thomas M. Burton at tom.burton@wsj.com
(END) Dow Jones Newswires
October 16, 2020 07:44 ET (11:44 GMT)
Copyright (c) 2020 Dow Jones & Company, Inc.
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