By Julie Steinberg And Michael Calia 

U.S. Bancorp said its profit edged up 2.2% in the most recent quarter as its revenue and average total loans grew, though a key measure of lending profitability narrowed.

Earnings and revenue beat Wall Street estimates, sending shares up nearly 3% in early afternoon trading.

The bank posted earnings of $1.49 billion, up from $1.46 billion in the prior-year period. On a per-share basis, earnings rose to 79 cents from 76 cents. One-time items tied to equity investments and accruals for legal matters boosted earnings by one cent a share in the latest period.

Revenue at the Minneapolis-based bank rose 5.7% to $5.17 billion.

Analysts had expected 77 cents a share in earnings and $5.01 billion in revenue, according to Thomson Reuters.

Average total loans rose by 5.9%.

The bank also benefited from a boost in noninterest income revenue. Noninterest income, which is generated from business lines like credit and debit card revenue and mortgage banking revenue, totaled $2.37 billion in the quarter, up 10% from a year earlier. Investment products fees and trust and investment management fees drove the increase.

U.S. Bancorp has been investing in its wealth management and corporate trust segments, both of which are considered pieces that "complement other businesses" and "offer diversification" for the company, said Chief Operating Officer Andy Cecere in an interview.

The company this week promoted Mr. Cecere, 54 years old, to his current position. He previously served as chief financial officer. He was replaced in that capacity by Kathleen Ashcraft Rogers, who previously served as executive vice president for business line planning and reporting.

On an earnings call Wednesday with analysts, Chief Executive Richard Davis said the promotion for Mr. Cecere was "an opportunity to prove that he can run virtually all parts of the company in the eventual opportunity for him to run it someday."

Net interest margin, an important measure of lending profitability, fell to 3.14% from 3.4% a year earlier on lower reinvestment rates on investment securities and lower rates on new loans.

The bank had posted growth in profit and loans recently, although it faces a tough environment in which low interest rates limit interest income.

Like some other regional banks, U.S. Bancorp has been carving out a presence within traditional Wall Street capital markets activity to help boost revenue. Mr. Cecere said in the interview that the bank plans to develop more deeply across business lines including foreign exchange and bond underwriting.

He said the bank in 2015 plans to invest in areas "we haven't focused on, " but said the bank is probably not focusing on traditional mergers and acquisitions activity.

Write to Julie Steinberg at julie.steinberg@wsj.com and Michael Calia at michael.calia@wsj.com

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