By Jeannette Neumann and Christopher Bjork 

MADRID-- Banco de Sabadell SA's bid for TSB Banking Group PLC reflects a maxim of post-crisis banking in Spain: Diversify.

The profitability of Spanish banks such as Sabadell, the country's No. 5 lender by market value, was hit hard when a real estate boom went bust in 2008. Property developers defaulted on tens of thousands of loans, saddling banks with bad debts that they are still working through today.

Spanish banks with massive international operations, Banco Santander SA and Banco Bilbao Vizcaya Argentaria SA, which have units from the U.K. to Latin America, fared better during the downturn, buoyed by returns in stronger markets overseas.

Executives from small- and medium-size banks that are primarily focused on the home market vowed in the aftermath of the crisis to look beyond Spain's borders.

In that sense, Sabadell's move is the boldest yet by a Spanish midsize bank. Both Sabadell and TSB on Thursday confirmed they are in talks about a possible GBP1.7 billion ($2.54 billion) takeover, in what would be one of the largest European cross-border banking acquisitions in years.

Some analysts said Thursday that the proposed offer deal was too ambitious. Shares in Sabadell were down 8.7% in early afternoon trading.

Sabadell, which purchased six lenders in Spain between 2006 and 2014, is already digesting financial-crisis era acquisitions, such as a troubled regional savings bank called Caja de Ahorros del MediterrĂ¡neo, known as CAM, that it purchased in 2011 for EUR1.

TSB said Sabadell had indicated that it expects to finance the proposed takeover "on a capital neutral basis."

Francisco Riquel, an analyst with Madrid-based financial-services firm N+1 Group, said Sabadell is likely to need around EUR1.2 billion in capital to fund the deal. A rights issue at a 30% discount to its current share prices would require Sabadell to increase its share count by around 20%, diluting current shareholders, Mr. Riquel said in a research note Thursday.

Sabadell has long affirmed its aim to expand internationally. Still, Mr. Riquel said, "We thought this was a long-term strategic ambition."

He said: "We would have preferred Sabadell to deploy its excess capital in its Spanish market [organically or through acquisitions] now that [Gross Domestic Product] growth is gathering pace."

In an interview with The Wall Street Journal last year, Chairman Josep Oliu said that a lesson learned in the Spain's financial crisis was that it was necessary for the bank to build an international presence. Mr. Oliu has been chairman since 1999 and received a Ph.D. in economics from the University of Minnesota. Chief Executive Jaime Guardiola also has international experience, after running BBVA's Mexican unit for years.

Berenberg Bank analyst Nick Anderson said the takeover talks with TSB raised questions about Sabadell's confidence in its home market.

"By bidding for TSB, they're saying their marginal euro is best invested in a mature market at the top of cycle [U.K.] rather than a supposedly recovering economy at [the] start of [a] cyclical rebound [Spain]," Mr. Anderson said.

Sabadell already owns Miami-based Sabadell United Bank and corporate lending units in Mexico, but the bank said this week that it was keen to increase the proportion of its annual net profit generated abroad to 30% from around 8% now. It didn't say when it aimed to hit that figure.

Sabadell has said it expects to get its full banking license in Mexico this summer and that it would focus on loans to small- and medium-size businesses.

The takeover talks come as another Spanish lender, Caixabank SA, has made a bid to expand in neighboring Portugal. Caixabank, Spain's No. 3 bank by market value, last month offered to buy the 55.9% of Banco BPI SA that it doesn't already own. The takeover bid has been muddled as a top shareholder has suggested BPI instead merge with another Portuguese bank.

Write to Jeannette Neumann at jeannette.neumann@wsj.com and Christopher Bjork at christopher.bjork@wsj.com

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