By Carla Mozee, MarketWatch

LONDON (MarketWatch) -- U.K. stocks gained Friday as Royal Bank of Scotland Group PLC shares put in their best performance in more than two years after an upbeat profit report, while AstraZeneca PLC shares slipped after the drug maker rejected a sweetened merger offer from Pfizer Inc.

The U.K.'s FTSE 100 closed up 0.2% at 6,822.42, a move that pushed the benchmark index to a 2.1% rise for the week, its third consecutive weekly increase.

Stocks in London held a grip on gains as the broader European market hit intraday lows, falling further as the United Nations Security Council met at the request of Russia to discuss the "serious escalation of violence in Ukraine," according to French news agency AFP.

A Ukrainian military operation launched Friday left "many" pro-Russian activists dead as Ukraine tried to regain control of the pro-Russian separatist stronghold of Slovyansk, Britain's BBC reported.

Tensions between Moscow and Kiev intensified ahead of three-day weekend in the U.K. and Ireland, where trading won't take place on Monday in observance of the Early May Bank holiday.

The FTSE 100's advance on Friday was aided by an 8.2% upswing in RBS shares after the bank's first-quarter profit surged to 1.2 billion pounds ($2.02 billion) from GBP393 million a year ago. The performance was the best for RBS's shares since January 2012, according to FactSet data. The rise in quarterly profit for the 80% U.K. government-owned bank came as bad debt in its loan books fell, and as provisions for legal issues related to misconduct from the financial crisis decreased.

Shares of InterContinental Hotels Group also rallied 8.2% after the Holiday Inn and Crowne Plaza chains owner said it plans to distribute $750 million to shareholders through a special dividend. The move comes after the company reported a 6% rise in first-quarter revenue for each available room.

Meanwhile, AstraZeneca PLC rebuffed Pfizer Inc.'s (PFE) acquisition offer, which was raised to GBP50 a share ($84.87), valuing AstraZeneca at GBP63 billion ($106.43 billion).

"Inadequate" is what AstraZeneca called financial and other terms of the offer. AstraZeneca shares had turned up during the session, but concluded the day with a 0.2% decline. The shares still finished the week up by 17.8%, their strongest week on record, according to FactSet.

"Pfizer's proposal would dramatically dilute AstraZeneca shareholders' exposure to our unique pipeline and would create risks around its delivery. As such, the board has no hesitation in rejecting the proposal," said AstraZeneca Chariman Leif Johansson in a statement.

In January, Pfizer had valued the company at GBP46.61 a share, or about $100 billion.

Reckitt Benckiser Group PLC shares fell 0.9% following a Bloomberg report that Bayer AG is close to reaching an agreement to take over Merck & Co. Inc.'s (MRK) consumer-health care unit, in a deal that values the unit at $14 billion.

Earlier this week, Reckitt Benckiser said it was in talks to buy the unit from Merck, adding that it was "part of a competitive process." A Bayer representative declined to comment on the Bloomberg report, while a Merck spokesperson wasn't immediately available.

In other developments Friday, Markit and the Chartered Institute of Purchasing & Supply said U.K. house-building activity grew in April.

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