By Chelsey Dulaney 
 

Allergan PLC said Tuesday that it has reached a deal to buy the exclusive world-wide rights to two of Merck & Co.'s experimental migraine drugs for an upfront payment of $250 million.

Merck also could receive milestone and royalty payments based on the commercialization of the two calcitonin gene-related peptide receptor antagonists, which are being developed for treatment and prevention of migraines.

Dublin-based Allergan expects to begin a late-stage study for one of the oral drugs in 2016, while the company expects to begin a mid-stage study for the other next year.

Allergan has been bulking up its portfolio through a string of deals recently.

On Monday, Allergan said it struck a deal to buy Oculeve, a maker of experimental dry-eye disease treatments, for an unpfront payment of $125 million in cash.

That follows the Botox maker's deal last month to buy Kythera Biopharmaceuticals Inc. and its newly approved double-chin treatment in a $2.1 billion deal that aims to plump up its lineup of cosmetic medicines.

Write to Chelsey Dulaney at chelsey.dulaney@wsj.com

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