By William Mauldin 

Major trade legislation favored by President Barack Obama and Republican leaders passed a Senate hurdle on Wednesday, despite opposition from some Democrats.

The "fast track" bill, which would pave the way for a sweeping trade agreement among 12 Pacific countries, cleared the Senate Finance Committee by a vote of 20 to 6. It passed along with a measure backed by Sen. Chuck Schumer (D., N.Y.) that would seek to punish foreign companies that benefit from alleged currency manipulation overseas. Another key currency provision was defeated.

The fast track bill's progress in the Senate came on a day when Mr. Obama faced a setback in the House, where his trade push faces the biggest obstacles. The top Democrat in the House, Rep. Nancy Pelosi (D., Calif.) threw her support behind a rival piece of trade legislation. The alternative trade legislation, which Rep. Sander Levin (D., Mich.) said he would introduce Thursday, includes safeguards popular among labor groups and provisions to buttress the Detroit auto industry, as well as strong provisions on currency manipulation.

The lack of support among Democratic leaders, made clear on Wednesday, means the administration will have to work harder to clinch necessary Democratic votes for the main, bipartisan fast track bill, also known as trade promotion authority. The legislation, enacted under previous presidents, allows trade agreements to get a simple majority vote in Congress, without procedural delays or amendments.

Besides fast track, the Senate committee approved three other bills that would provide a safety net for workers who lose their jobs to trade, renew programs that give preferential tariffs to developing countries, and facilitate customs processes and enforcement.

In the customs bill, the committee easily approved Mr. Schumer's currency legislation, which was opposed by the administration. "It's time to do something that might actually solve this problem and help America," Mr. Schumer said, pledging to get the legislation enacted "one way or another." He opposed the fast track bill, along with four other Democrats and Sen. Richard Burr (R., N.C.).

But the committee rejected another currency-manipulation measure, offered as an amendment to the fast track bill. Introduced by Sen. Rob Portman (R., Ohio) and backed by unions, the amendment would have pushed the administration to negotiate enforceable currency rules in the Pacific trade agreement, known as the Trans-Pacific Partnership, or TPP.

The committee leaders sought to present Mr. Portman's amendment, supported by Mr. Schumer and other Democrats, as a poison pill. "If this amendment passes, you can kiss TPP goodbye," warned Sen. Orrin Hatch (R., Utah), the committee's chairman. "This is an amendment that is a bridge too far," said Sen. Ron Wyden (D., Ore.), the top Democrat.

The Obama administration opposes putting binding currency rules in trade agreements or U.S. law, citing objections of trading partners and concerns that U.S. monetary policy could be challenged.

But Ford Motor Co. had pushed lawmakers Wednesday to support the currency rules, saying they could prevent Japan, the other giant economy in the TPP talks, from intervening in the yen to gain an advantage. Detroit is among the biggest critics of the TPP talks, while Japanese auto makers support the agreement.

Following the Senate panel's passage of fast track and the related bills, the House committee that oversees trade, led by Rep. Paul Ryan (R., Wis.), may vote on a similar package as early as Thursday.

Business groups and administration officials are seeking to enact fast track as soon as possible in an effort to clinch a TPP agreement and get the deal enacted before the presidential campaign season further complicates the politics of trade.

But labor unions and allies ranging from environmental organizations to some conservative groups are working to block the TPP and fast track, citing potential job losses and concerns about labor and environmental conditions in Vietnam and other TPP countries.

Siobhan Hughes contributed to this article.

Write to William Mauldin at william.mauldin@wsj.com

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