By Stephanie Yang and Lisa Beilfuss 

BB&T Corp. said its profit edged down 1.6% in the first quarter, as low interest rates pressured the bank's net interest margin and results missed Wall Street's expectations.

The Winston-Salem, N.C., lender on Thursday posted net income of $488 million, or 67 cents a share, down from $496 million, or 68 cents a share, a year earlier. Excluding merger-related charges, per-share profit was 68 cents, down a penny from a year earlier. Revenue rose 1.5% to $2.34 billion.

Analysts, according to Thomson Reuters, had projected 70 cents in per-share earnings on $2.4 billion in revenue. Shares fell about 2.4% in morning trading.

Mortgage-banking income at the lender jumped 48.6% in the quarter to $110 million. Sequentially, mortgage-banking income fell 57% from the fourth quarter.

BB&T, one of the largest lenders in the southeastern U.S., said net interest income fell 2.6% in the quarter to $1.35 billion. Like most other banks, continued low interest rates put downward pressure on BB&T's net interest margin. The metric, an important measure of lending profitability, slid to 3.33% from 3.52% a year earlier. The bank pointed to lower interest rates on new loans and runoff of loans acquired from the Federal Deposit Insurance Corp.

BB&T Chief Financial Officer Daryl Bible said on an earnings call Thursday he expects net interest income to increase over the year, assisted by pending acquisitions of Bank of Kentucky Financial Corp. and Susquehanna Bancshares Inc.

Despite recent regulatory scrutiny of bank deals, executives on the call were confident that both mergers would go through as planned. The Bank of Kentucky deal is expected to close in the second quarter, and Susquehanna in the second half of the year.

Chief Executive Kelly King said he expects the deals to "ramp up revenue" over a shorter period relative to other traditional mergers.

"Both opportunities are fantastic, and at this point we feel more excited about them than the day we announced," Mr. King said.

When asked about the bank's potential interest in GE assets, Mr. King said BB&T is evaluating everything available in the marketplace, but wouldn't be interested in any megadeals--unlike Wells Fargo, which has shown interest in tens of billions of dollars of loans in the GE Capital portfolio.

"We're fairly positive that some of those acquisition opportunities will come to fruition," he said.

The bank said its noninterest expenses rose by $28 million to $1.4 billion. BB&T said rising personnel expenses due to in part to higher pension costs were partially offset by a decline in loan-related expense.

During the quarter, the company's adjusted efficiency ratio inched up to 58.5% from 58.2%. An efficiency ratio measures how much it costs a bank to produce revenue--the lower the ratio, the more efficient the bank is. BB&T had targeted a ratio of 56% by the end of last year.

Average deposits slipped 2.4% to $784 million. The company said, though, that its deposit mix improved, with average noninterest-bearing deposits representing 30.6% of total deposits, up from 30% in the prior quarter.

The bank was able to benefit from its fee-generating noninterest-income businesses. Noninterest income rose 7.5% to $997 million, driven by higher mortgage-banking income and insurance income.

Write to Stephanie Yang at stephanie.yang@wsj.com and Lisa Beilfuss at lisa.beilfuss@wsj.com

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