By Mike Esterl 

PepsiCo Inc. said Friday it will remove aspartame from Diet Pepsi in the U.S. and replace it with sucralose, another artificial sweetener, in a bid to reverse plunging sales.

The beverage company said it is making the move in response to consumer surveys showing the presence of aspartame to be the No. 1 reason that Americans are scaling back on diet colas.

U.S. consumers are backing away from artificial sweeteners amid health concerns, even though the Food and Drug Administration says such sweeteners are completely safe. Aspartame has proved particularly unpopular with consumers of late.

PepsiCo said it continues to stand behind the safety of aspartame and will keep using it outside the U.S. But it said it would start shipping Diet Pepsi without aspartame to U.S. stores in August.

Diet Pepsi sales fell 5.2% by volume in the U.S. last year, according to industry tracker Beverage Digest.

Coca-Cola Co.'s U.S. diet soda sales also have fallen sharply the last two years. U.S. volumes of Diet Coke, the country's leading diet soda by sales, fell 6.6% last year, according to Beverage Digest.

Coke Chief Executive Muhtar Kent didn't say in an interview with CNBC on Friday morning whether the company would also consider removing aspartame from Diet Coke.

"I'm not here to defend aspartame," Mr. Kent said during the interview, when asked about PepsiCo's move.

But he added that the European Food Safety Authority recently came out with a report saying aspartame is one of the most "researched ingredients in the world and safe."

In a statement Friday, Coke said "there are currently no plans to change the sweetener" for Diet Coke. "All of the beverages we offer and ingredients we use are safe," it added.

PepsiCo said it has no plans to remove aspartame from other diet soda offerings, including Diet Mountain Dew and Pepsi Max, a diet cola marketed more aggressively to males.

Aspartame "doesn't even hit top 10" among concerns of Pepsi Max drinkers, Seth Kaufman, senior vice president of Pepsi and flavors in North America, said in an interview.

Aspartame "remains an important sweetener option for us," he added.

Some studies starting in the 1970s linked aspartame to cancer. The FDA, which approved aspartame in 1981, says such studies, including an Italian one in 2005, were flawed.

But consumer fears over artificial sweeteners, particularly aspartame, have been amplified by the Internet in recent years.

Some studies have suggested that zero-calorie artificial sweeteners, not just aspartame, can trip up body mechanisms that regulate caloric intake. Some have also shown a correlation, but not established causation, between diet soda and obesity, diabetes and heart disease.

The American Beverage Association says artificial sweeteners are among "the most studied and reviewed ingredients" over four decades, and are safe weight-loss tools, positions that have been echoed by the American Diabetes Association and the Academy of Nutrition and Dietetics.

Tripp Mickle contributed to this article.

Write to Mike Esterl at mike.esterl@wsj.com

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