Japanese pharmaceutical company Eisai Inc. said Thursday that it would cut about 25% of its U.S. workforce as part of a plan to restructure its operations in the country.

"The actions we are taking will ensure Eisai stays competitive in a rapidly changing business environment," Chief Executive Yuji Matsue said in a news release, adding that the company is "fully committed to the U.S. market."

Eisai said it had no plans to close any of its main offices or facilities. The company's U.S. headquarters is in Woodcliffe, N.J., and it has additional locations in North Carolina and Pennsylvania.

The Tokyo-based drug company focuses on drugs for neurology, oncology and metabolic diseases. In June 2013, Eisai teamed with U.S.-based pharmaceutical company Arena to develop the weight-loss drug Belviq. Last week, fellow diet drug maker Vivus Inc. announced U.S. job cuts of its own.

Eisai's U.S. operations include research and development, manufacturing, sales and marketing, and administrative functions. The company said it expected the new structure to be in place by May 1.

In 2014, Eisai reported $600.4 million in sales. The Americas segment contributed 26.5% to the top line.

Write to Lisa Beilfuss at lisa.beilfuss@wsj.com

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