NEW YORK, July 20, 2015 /PRNewswire/ --
ACI Association has initiated research coverage on ImmunoGen,
Inc. (NASDAQ: IMGN). Select highlights from the internally released
reports are being made available to the general public (included
below), with access to the entirety of the research available to
new members.
Today, membership is open to readers on a complementary basis at
the following URL: http://www.aciassociation.com/?c=IMGN
Highlights from our IMGN Report include:
- Ongoing Phase 1 Trial Findings - On May 30, 2015, ImmunoGen, Inc. reported the first
clinical findings from the ongoing Phase 1 trial of Company's
unique, FRα-targeting antibody-drug conjugate (ADC), mirvetuximab
soravtansine. The results showed that mirvetuximab soravtansine
(IMGN853) demonstrated notable single agent activity for patients
with platinum-resistant ovarian cancer.
- Study Details - The release stated that once the
recommended Phase 2 dose (RP2D) of mirvetuximab soravtansine was
established during dose finding, an expansion cohort was opened to
assess the safety and activity of this ADC specifically in the
treatment of patients with FRα-positive platinum-resistant ovarian
cancer. It was observed that nearly 80% of the patients screened
met the criteria for having FRα-positive disease. Twenty-two
patients were included in the study, out of which two were from the
dose-escalation phase of the trial and the twenty enrolled in the
expansion cohort at the time of data cutoff (April 30, 2015).
- Study Results - Out of 22 patients, 17 patients were
included in the efficacy analysis as the other five were still on
study and had not yet reached their first assessment. The results
showed that out of these 17 patients, nine had an objective
response (8 partial responses, 1 complete response) to treatment,
for an objective response rate (ORR) of 53%. The responses in six
of these nine patients were ongoing at the time of data cutoff,
with five of these six patients on treatment for more than 15
weeks.
- Phase 2 Trial Plans - Providing a glimpse of future
course of action, Dr. Charles
Morris, EVP and Chief Development Officer of ImmunoGen,
stated that on the basis of these findings, the Company would be
executing a development plan designed to advance mirvetuximab
soravtansine as quickly as possible while also recognizing the
potential to benefit the greatest number of patients. He further
said that the Company is preparing to initiate a Phase 2 trial in
late 2015 that will assess this ADC as a single-agent treatment for
patients with FRα-positive platinum-resistant ovarian cancer.
- Trials for Other Clinical Studies - Commenting on the
potential of mirvetuximab soravtansine for other types of cancers,
Dr. Morris said, "At the same time, we're preparing to initiate
testing of mirvetuximab soravtansine in combination regimens as a
potential therapy for patients with less heavily pretreated ovarian
cancer. We're also continuing to explore this promising ADC as a
treatment for other types of FRα-positive solid tumors, including
target-positive endometrial cancer."
To find out how this influences our rating on ImmunoGen, Inc.,
read the full report in its entirely here:
http://www.aciassociation.com/?c=IMGN
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