Researchers address drug-related toxicity in
chemotherapy and explore alternatives from traditional Chinese
medicine to treat diabetic neuropathy
XI'AN,
China, April 30, 2024 /PRNewswire/ --
Inflammatory bowel disease (IBD) is a common chronic
gastrointestinal disorder and current treatment strategies can
cause adverse effects. Thus, there is a need to identify
alternative compounds to treat IBD. Similarly, the dose-related
toxicity and efficacy of anticancer drugs must be monitored
accurately to improve the treatment outcomes. Moreover, over the
years, plant-based therapeutic compounds and traditional Chinese
medicine formulae have gained attention for their enhanced healing
effects. Volume 14, Issue 2 of the Journal of Pharmaceutical
Analysis (JPA), published in February 2024, addresses these issues in three
different studies, respectively.
The first study, published in Volume 14, Issue 2 of JPA,
identified and extracted a plant-based, acidic polysaccharide named
SUSP-4 from the herb Selaginella uncinata (Desv.) Spring.
This phytocompound significantly improved the symptoms of IBD such
as low body weight and high disease activity index during animal
experiments. It inhibited the immune response of macrophage
activation by altering the chemokine levels in treated animals and
ultimately affected the thiamine metabolic pathway and protected
against IBD. The corresponding author, Dr. Jinyong Peng states, "IBD reduces the level
of vitamin B1 (thiamine), which itself has an inhibitory effect on
inflammation, so a moderate supplementation of vitamin B1 may go a
long way towards preventing IBD in people."
In the second study, published in Volume 14, Issue 2 of
JPA, scientists employed spatiotemporal metabolomics to
closely monitor the administration of chemotherapeutic drug
oxaliplatin in animal models. They used biocompatible microprobes
to gather information about the efficacy and dose-related toxicity
of the drug, locally administered via in vivo lung
perfusion. The study identified a total of 139 specific compounds
that indicated acute lung injury. The corresponding author, Prof.
Janusz Pawliszyn shares, "This
study might be a starting point for future developments of tools
that might be applied to prognosticate the patient's pathological
response to the selected chemotherapy treatment."
In the third study, published in Volume 14, Issue 2 of JPA,
researchers studied diabetic peripheral neuropathy (DPN), a
condition where the blood vessels and nerves are damaged due to
improperly regulated metabolic pathways. They specifically targeted
carbohydrate metabolism and developed a metabolomics approach using
a high-performance ion chromatography technique and studied DPN in
rats and humans. The researchers found that JinMaiTong (JMT), a
traditional Chinese medicine supplement, effectively treated DPN by
inducing the activation of adenosine monophosphate-activated
protein kinase and other downstream proteins involved in energy
profile regulation. The corresponding author, Prof. Xiaochun Liang concludes by saying, "Our
study proved that the TCM formula JMT improved the neurological
functions and attenuated the pathological damages of peripheral
nerve in the progress phase of DPN rats. In-vivo and in-vitro
studies demonstrated that the neuroprotective capacities of JMT
should be attributed to the improved energy status with the vital
role of the activated AMPK signaling, which is crucial for a better
understanding of the clinical effect of JMT and proposes a
promising treatment strategy for DPN for decades."
Overall, these articles together underscore the importance of
metabolomics analysis.
Reference
Title of original paper: Gut microbiome-based thiamine
metabolism contributes to the protective effect of one acidic
polysaccharide from Selaginella uncinata (Desv.) Spring
against inflammatory bowel disease
Journal: Journal of Pharmaceutical Analysis
DOI: https://doi.org/10.1016/j.jpha.2023.08.003
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SOURCE Journal of Pharmaceutical Analysis