Waters Announces New Reference Library for Metabolite Profiling by Ion Mobility Separations
June 06 2016 - 10:48AM
Business Wire
With more than 900 Collision Cross Section
Values, Metabolic Profiling CCS Library to Increase Researcher
Confidence during Untargeted Studies
Waters Corporation (NYSE: WAT) has introduced a new metabolic
profiling reference library for use during ion mobility mass
spectrometry-based research. The Metabolic Profiling CCS Library
includes more than 900 measurements of collision cross-section
(CCS) values, which measure the gas phase three-dimensional shape
of a molecule for an additional identification coordinate used to
confirm analytical results. The library also includes more than 600
MS/MS spectra.
The library is included in Waters® UNIFI® Scientific Information
System, the company’s unique software platform that combines
instrument control and data analysis, visualization, and management
of both chromatography and mass spectrometry results. The library
is also available for use with Progenesis® QI Software. The new
resource was announced at the 64th American Society for Mass
Spectrometry (ASMS) meeting.
The Metabolic Profiling CCS Library enables research scientists
to accurately identify biomarkers in complex sample matrices when
using ion mobility separations. A collisional cross section (CCS)
value is a precise physicochemical property of an ion related to
its size, shape, and charge in the gas phase. In untargeted
metabolomics studies involving small sample amounts that are highly
complex, researchers can use CCS values in the library to confirm
identifications of endogenous metabolites and lipids showing
statistically significant changes between different sample
groups.
“Metabolomics and lipidomics are critical techniques for
biomarker discovery and translational research, whether identifying
endogenous biomarkers of interest for efficacy, or understanding
disease progression. Ion mobility mass spectrometry is an enabling
technology for performing untargeted metabolomics studies where the
researcher wants to learn as much as possible about the underlying
biology. Where ion mobility increases overall chromatographic peak
capacity, CCS values improve confidence that a researcher has
correctly identified a particular metabolite/s,” commented David
Heywood, senior business development manager for Waters’ omics
solutions.
The Metabolic Profiling CCS Library for UNIFI is available with
the Vion™ IMS QTof and SYNAPT® G2-Si HDMS® Systems, high-resolution
mass spectrometers that reduce the complexities of executing ion
mobility-based analyses.
When used in conjunction with Progenesis QI Software, which aids
in the identification of compounds that are significantly changing
in a sample, the technologies enable researchers in biomarker
identification to robustly and routinely mine complex samples with
high coverage and statistical rigor.
For more information: http://www.waters.com/clarity
About Waters Corporation
(www.waters.com)
Waters Corporation (NYSE: WAT) develops and manufactures
advanced analytical and material science technologies for
laboratory dependent organizations. For more than 50 years, the
company has pioneered a connected portfolio of separations science,
laboratory information management, mass spectrometry and thermal
analysis systems.
Waters, UNIFI, Progenesis, Vion, SYNAPT, and HDMS are trademarks
of Waters Corporation.
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Waters CorporationKaren Haas, +1 508-482-3363Public
Relationskaren_haas@waters.com
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