By Alison Sider 

Dow Chemical Co. profits rose 41% in the first quarter, but the company could have made more if falling crude-oil prices and the strength of the U.S. dollar compared with global currencies hadn't cut into sales.

The chemical maker beat analyst expectations when it reported a profit of $1.48 billion, or $1.18 a share, up from $1.05 billion, or 79 cents a share, in the prior-year period. Results were buoyed by Dow's sale of its Angus Chemical company and its sodium borohydride business. Revenue decreased 14% to $12.4 billion.

Excluding asset-sales gains and other one-time items, per-share earnings were 84 cents for the quarter. Analysts polled by Thomson Reuters expected per-share profit of 76 cents. Dow shares rose 1.2% to $50.62 in midday trading.

The price of oil has fallen by half since its June peak, which is a mixed blessing for Dow.

The company has benefited in recent years from high oil prices and cheap North American natural gas. Dow Chemical uses cheaper U.S. gas to make plastics and consumer goods, while its competitors rely on pricier oil-based fuels, cutting into their profits.

Andrew Liveris, chief executive of Dow, said plunging oil prices would ultimately work to the company's advantage by stimulating the global economy and demand for its products. During the first quarter, the company reported higher sales volumes in most of its divisions except agricultural chemicals.

"We see good demand growth," Mr. Liveris said Thursday in an interview with The Wall Street Journal. "It's not gangbuster growth, but targeted growth."

Dow reported its highest profit margins in a decade, driven by a segment that includes packaging and plastics. Oil prices are also less critical today to the company than they have been in the past, because Dow has pivoted toward different, more profitable products, Mr. Liveris said.

"There's no way the Dow of old would have obtained these results," he said.

But lower fuel costs helped boost Dow's results, which may not be fully sustainable if energy prices rise, warned Cowen & Co. analyst Charles Neivert.

"The theme for the results centered on margin gain through lower raw material costs that more than offset pricing declines and currency headwinds," he said in a note to clients.

Dow, based in Midland, Mich., recently agreed to spin off a significant portion of its chlorine business to smaller chemical-maker Olin Corp. in a cash-and-stock deal valued at $5 billion, as part of its effort to shift toward making higher-profit chemicals and products. That deal is expected to close by the end of the year.

Tess Stynes contributed to this article.

Write to Alison Sider at alison.sider@wsj.com

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