By William Horobin and Jason Chow in Paris and Robert Wall in London 

An Airbus A320 flying from Barcelona to Düsseldorf with 150 passengers and crew on board crashed in a remote, hard-to-reach region of the French Alps on Tuesday, in the worst air disaster in France in more than three decades.

The flight operated by Germanwings, a budget airline whose parent company is Deutsche Lufthansa AG, went down near Méolans-Revel, a small village of 300 surrounded by steep mountains.

"The conditions of the accident suggest there are no survivors," French President François Hollande said in a brief televised address.

Flight 9525 reached an altitude of 38,000 feet at 10:45 a.m., or 44 minutes after takeoff, and a minute later began an eight-minute descent before crashing, Germanwings Chief Executive Thomas Winkelmann said.

The airline said it is not sure why the plane began to fly at a lower altitude and air traffic control had not authorized a descent, a Germanwings official said.

Air-traffic authorities based in Aix-en-Provence tried to make contact several times with cockpit crew when they noticed the plane dipped below cruising altitude, said Roger Rousseau, the secretary general for the SNCTA union of air-traffic controllers.

"Air-traffic control made multiple attempts and there was always no response," he said. "There was no distress call from the plane. No mayday call, no squawk from the transponder--nothing."

Mr. Rousseau said the plane didn't deviate from its course as it lost altitude, which he said is an unusual pattern for a plane in distress.

"The plane kept on its trajectory, and that's surprising to us. If there's a loss of control, pilots usually lose their way too," the union delegate said. "That didn't happen in this case."

One of the black box recorders from the flight had been recovered, French Interior Minister Bernard Cazeneuve said early Tuesday evening. France's flight safety agency, BEA, will begin analyzing the contents of the black box later Tuesday, the interior ministry said.

The recording devices, which store conversations on the flight deck and data on the aircraft systems, are usually key to determining the cause of a crash. Extracting the information can take only a few hours, though an in-depth analysis usually takes far longer.

BEA has dispatched seven investigators to the scene along with three German investigators and technical advisors from Airbus, the French agency said.

Helicopters flying over the snow-covered crash area have spotted wreckage but the remote location would likely make it hard for recovery workers and investigators to reach the site, French officials said. A lawmaker from the region who said he had flown over it with the French interior minister described it as a horror.

"I'm hoping there are survivors and the priority is to check for any signs of life," Christophe Castaner said on French television. "But when you see there is only debris of small size and body parts, it's awful."

With no direct road access, emergency workers were bracing for a complex operation that could involve hourslong treks and helicopter relays. Complicating matters, heavy snow was forecast Tuesday evening.

At an altitude over 6,500 feet, the crash site is at least two hours away from the nearest road for any emergency crews hiking to the area, said Damien Bon, a marshall with the local mountain police. Five helicopters have been dispatched, he said, along with 300 emergency workers.

"It is really hard to get there," Mr. Bon said.

Mr. Hollande said he had spoken to German Chancellor Angela Merkel--who he said was "particularly shocked." Flanked by the king of Spain, at the start of an official visit in Paris, Mr. Hollande said he and the Spanish monarch had decided to call off their meeting.

Germanwings said there were 144 passengers and six crew on board, including at least 67 Germans. Spain's government said it believes dozens of Spaniards may have perished.

A group of 16 secondary school students and two teachers booked on the flight are presumed to be among the victims, the deputy mayor of the western German town of Haltern am See said. The students had been on an exchange program at a partner school in Spain, Hans-Josef Böing said.

On Wednesday, Mr. Hollande will travel to Seyne, a small town near the crash site, where he will meet Ms. Merkel and Spanish Prime Minister Mariano Rajoy.

"We still don't know much beyond the scarce details of the flight, and there must be no speculation on the causes of the crisis--everything will be thoroughly investigated," Ms. Merkel told reporters in Berlin, expressing her "deep sorrow" over the crash.

French officials, cited in French media, initially said pilots had issued a distress call but later clarified the alert had been issued by a ground-control officer, who saw the plane veering off normal course on his radar.

The pilot of the A320 had more than 10 years of service. The plane underwent regular maintenance on Monday and had its last major safety check in 2013, Mr. Winkelmann said. The plane had undergone all required safety upgrades after European safety regulators issued a series of safety bulletins for the aircraft type.

Lufthansa Chief Executive Carsten Spohr said via Twitter that "if our fears are confirmed, this is a dark day for Lufthansa" and expressed "deepest sympathy" for family and friends of passengers and crew.

"We are in mourning because it's a tragedy that happened on our soil," Mr. Hollande said, adding that several French ministers were on their way to the crash site.

French authorities said they had mobilized 13 coroners to collect body samples and help identify victims.

At Barcelona's El Prat airport, a crisis center for relatives of passengers of the Germanwings flight has been staffed with a team of psychologists and medical workers, said Artur Mas, the president of the region of Catalonia. The regional government will also arrange transportation for family members who wish to travel to the crash site in France, Mr. Mas added.

The German Federal Bureau of Aircraft Accident Investigation plans to send three officials to France to aid the crash probe, a spokesman for the agency said. France would lead the probe, though agencies from other countries with a stake in a crash usually are involved.

Airbus typically also supports such investigations with technical experts. The Toulouse, France-based plane maker said it was "aware of the media reports and all efforts are now going towards assessing the situation" and that it would provide updates as available.

The crash is the first fatal accident for Lufthansa since 1993, when two persons died in an Airbus A320 crash in Poland, according to the Aviation Safety Network, an accident-tracking site run by the not-for-profit Flight Safety Foundation. A crew member and passenger died when the plane came off the runway on landing. Lufthansa's Germanwings budget unit, founded in 2002, has had no previous fatal crashes.

The Airbus A320 is the plane maker's most popular model, with more than 3,600 in service and more than 4,700 sold. The A320 family of planes suffers about 0.08 crashes per million flights, according to website AirSafe.com.

The crash rate is about the same as for equivalent Boeing narrowbodies, it said.

Airbus said the plane was delivered in 1991 to Lufthansa and had logged around 58,300 flight hours in some 46,700 flights. The plane was transferred to Germanwings last year, the carrier said.

The A320 was powered by CFM56-5 engines from CFM International, a joint venture of France-based Snecma and General Electric Co., a GE spokesman said. The companies have offered their assistance to investigators.

The A320 has been involved in some high-profile crashes, though, including last year's crash of an AirAsia jetliner in Indonesia. It was also the plane type involved in the so called "Miracle on the Hudson" on Jan. 15, 2009, when a US Airways plane taking off from New York's LaGuardia Airport lost power in both engines after encountering a flock of Canada geese. Pilot Chesley "Sully" Sullenberger landed the plane on the Hudson River.

Airbus is working on an updated, more efficient version of the plane, called the A320neo for "new engine option" that is due to enter service this year.

Commercial jet crashes are rare in European airspace, especially in mountainous areas. In 1992, an A320 operated by Air Inter collided with a 2,700-foot ridge on approach to Strasbourg, in eastern France, killing 87 people.

Tuesday's accident was the deadliest crash in France since 1981, when an Adria Airways MD80 crashed in Corsica killing 173 passengers and 7 crew. It was the deadliest crash in Western Europe since Aug. 20, 2008 when a Spanair MD-82 crashed killing 148 passengers and 6 crew, and injuring 18 more onboard.

The crash of a Concorde supersonic jet operated by Air France in 2000 killed 113 people.

Stacy Meichtry and Christopher Bjork contributed to this article.

Write to William Horobin at William.Horobin@wsj.com

Corrections & Amplifications

The designation of the Germanwings flight that crashed is Flight 9525. An earlier version of this article incorrectly stated it as U49525. (March 24, 2015)

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