By Jonathan D. Rockoff 

Two years ago, Actavis PLC was a relatively small seller of generic medicines with an unpronounceable name. After it seals its $66 billion deal for Allergan Inc., announced Monday, the company would be one of the globe's largest drug makers by sales, led by the antiwrinkle treatment Botox.

The rapid rise of Actavis was fueled by seismic changes reshaping health care, and then turbocharged by Allergan's heated efforts to slip from the grasp of a hostile suitor. To thwart detection as they sealed the deal, executives said the two companies held recent meetings in lawyers' offices far from corporate headquarters, and with Allergan CEO David Pyott checking into hotels under assumed names.

Mr. Pyott said he finally agreed to the deal this weekend during a cellphone call, marred by poor reception. Actavis will pay $219 a share, about 60% in cash and the rest in Actavis stock. The companies expect a deal, which must be approved by shareholders and regulators, would close in the second quarter next year and be accretive within the first year.

The combined company would sell a range of eye, skin and stomach drugs, led by the well known brand Botox. The company would have $23 billion in sales next year, more than 30,000 employees and a market capitalization of $128 billion, about 12 times Actavis's equity value just two years ago.

"We will create a top-10 pharmaceutical company," Actavis Chief Executive Brent Saunders said in a conference call.

But Actavis's entry into the ranks of Big Pharma will come at a hefty price for the company, its many employees and U.S. tax coffers. To reach its financial targets, Actavis plans to cut at least $1.8 billion in costs, including $400 million in research spending. That doesn't include $475 million in costs Allergan already planned to cut since it came under pressure from Valeant.

The Dublin-based company is expected to have a 15% corporate tax rate. That could save the combined company hundreds of millions of dollars in taxes that California-based Allergan would have paid at a roughly 26% tax rate.

To put its hostile suitor Valeant Pharmaceuticals International Inc. out of reach, Actavis's offer pays $85.08 a share more than the value of Allergan stock before the company was put in play in April.

Actavis shares rose 1.7% Monday to $247.94, and Allergan shares were up 5.3% to $209.20. Valeant shares edged up 1.9% to $136.73.

Valeant Chief Executive Michael Pearson, who had teamed up with activist investor William Ackman and his hedge fund Pershing Square Capital Management LP to buy Allergan, indicated he was walking away, though they could always return should Actavis's share price drop and make its offer easier to top.

"Valeant cannot justify to its own shareholders paying a price of $219 or more per share for Allergan," Mr. Pearson said. "We will remain focused on delivering strong organic results and evaluating acquisition opportunities as we always have: prudently, in a disciplined manner, and in the best interests of our shareholders."

Mr. Saunders admitted Actavis paid up for Allergan. "But in the midst of doing that, we got a company and a team that shouldn't have been up for sale," he said during an interview. "This is a once-in-a-lifetime, a unique opportunity to transform our industry."

Actavis projects the combined company would achieve at least 10% in revenue growth in each of the coming years.

An acquisition of Allergan would cap Actavis's steep ascent to the ranks of Big Pharma in just a few years. The deal comes amid a reordering of an industry buffeted by patent expirations for blockbuster drugs, efforts to control health-care spending and low interest rates that have driven considerable deal-making, especially to cut corporate taxes.

Actavis (pronounced AK-tuh-vis) is a product of all of these forces. Operating as Watson Pharmaceuticals, the company took advantage of a wave of blockbuster patent expirations, selling generic versions of drugs like attention-deficit and hyperactivity disorder drug Concerta.

Yet Watson was so little known around the world that in late 2012 it took the name Actavis, after buying the Iceland generics firm that was better recognized.

But that was around the peak of the patent cliff for top-selling prescription drugs. Like its generic-drug rivals, Actavis searched for new ways to increase revenue going forward. It was among the first pharmaceutical companies to merge with a foreign company, in its case Warner Chilcott last year, in a so-called inversion deal to lower its tax rate.

Then this year, it paid $25 billion for Forest Laboratories and its brand-name pharmaceuticals. The deal added higher-margin brand-name drugs such as the Alzheimer's drug Namenda to its portfolio. The broader range of products also offered a way to sell baskets of drugs at different price points to hospital systems that were consolidating and trying to control spending.

Allergan became an option for Actavis, slowly, after Valeant made its bid and after Mr. Pyott's exploration of other escapes, including a potential deal for Salix Pharmaceuticals, foundered, people familiar with the matter have said. Meantime, Actavis had to avoid the designs of Pfizer Inc., which approached it about a deal.

Mr. Pyott said he read Actavis's securities filings and talked with Mr. Saunders over the past several months to see if the businesses would be a good match. Mr. Pyott said he was impressed by Actavis's relatively lean management structure, its heavy marketing to physicians, and success building sales for women's health and other drugs.

Last week, teams of senior leaders from both companies huddled at a law firm in Chicago to review the operations of each company, looking for potential skeletons.

Mr. Pyott said he checked into hotels under assumed names during the talks, and pulled a ski cap down over his head Sunday in New York City to prevent being seen. Actavis board members flew separately to Ireland and stayed at different hotels in the Dublin countryside to avoid detection while giving their blessing for a deal, according to Mr. Saunders.

The two chief executives reached a final deal during a cellphone call over the weekend that was interrupted at least once by bad service. "I said, Brent?" Mr. Pyott recalled. Then he called Mr. Saunders back to agree.

Liz Hoffman and David Benoit contributed to this article.

Write to Jonathan D. Rockoff at Jonathan.Rockoff@wsj.com

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