Video Release -- FEI and Oregon Health & Science University Install a Complete Correlative Microscopy Workflow in Newly Built...
December 15 2014 - 9:10AM
FEI (Nasdaq:FEIC) and Oregon Health & Science University (OHSU)
today announced an expansion of their Living Lab for Cell Biology
agreement that includes the installation of a complete correlative
microscopy workflow in the new Collaborative Life Sciences Building
(CLSB) on OHSU's campus. This expansion adds a new instrument, the
FEI CorrSightTM, to the OHSU-FEI correlative light and electron
microscopy suite.
A video accompanying this release is available at
http://www.globenewswire.com/newsroom/prs/?pkgid=29647
FEI's CorrSight is an advanced light microscope that integrates
multiple sample preparation protocols for correlative experiments
and enables researchers to observe live cell dynamics using visible
light microscopy and quickly fixes those cells for follow-on light
and electron microscopy when a targeted event or structure is
identified. The CorrSight system completes OHSU's correlative
microscopy workflow and will be used by researchers to develop
correlative light and electron microscopy (CLEM) assays for
high-content drug screening applications.
The OHSU/FEI Living Lab is part of the OHSU Center for Spatial
Systems Biomedicine (OCSSB) that combines physics, biomedical
engineering, chemistry and biology to study how cancer cells and
other diseases develop in the body. The multidisciplinary Center
for Spatial Systems Biomedicine is part of the OHSU School of
Medicine and the OHSU Knight Cancer Institute.
"Establishing the OHSU/FEI Living Lab with FEI in 2011 equipped
us with high-performance tools to visualize cell and tissue
structures at levels of detail that were not possible before, with
a specific mission to explore how cancer cells function differently
as they spread from the site of origin to other parts of the body.
With the installation of the new CorrSight microscope, we will now
have a complete correlative workflow that will allow us to better
understand complex diseases, such as HIV and cancer. In the near
term, we will contribute to the OHSU Knight Cancer Institute goals
of enabling early detection of lesions destined to become lethal
cancer, developing low toxicity treatments to prevent or keep early
lesions from becoming lethal and developing effective strategies to
better manage advanced cancers," said Joe Gray, Ph.D., director of
the OCSSB and associate director for translational research for the
OHSU Knight Cancer Institute.
"Among the advantages of the expanded Living Lab instrumentation
is the ability to view living samples and preserve those cells in a
fixed position for observation with both light and electron
microscopy," Gray said.
Peter Fruhstorfer, vice president and general manager of Life
Sciences, FEI, added, "Over the past several years, imaging
technologies have made their first steps toward usage in automated
high-content screening environments for unsupervised discovery. The
rich variety and wide field-of-view of light microscopy, when
combined with the exquisite detail offered by electron microscopy,
enables researchers to find and analyze molecular-scale structures
and events as part of a drug discovery process. An automated
combination of these techniques could be a powerful tool for
high-content screening of candidate compounds."
"A working protocol will be defined, enabling a known specific
cell sample type to be run through an entire workflow during
demonstrations," Fruhstorfer added. "The workflow will involve
multiple steps, leveraging the live cell imaging capability of the
complete set of instruments, as well as the scientific expertise of
OHSU and FEI researchers and staff."
The goals of the expanded OHSU/FEI Living Lab collaboration
include: improvements in image acquisition speed, automation, data
handling, improved image analysis, more challenging electron
microscopy (EM) sample preparation protocols, and three-dimensional
EM acquisition. Development of high-content screening workflows for
biologically-relevant problems also will be explored.
In addition to the CorrSight system, the CLSB facility includes
several other microscopes from FEI that complete the correlative
microscopy workflow, such as: Titan Krios™ transmission electron
microscope (TEM) – the world's most powerful commercially-available
TEM; a Tecnai™ T12 TEM; and a Tecnai with iCorr™ fully-integrated
light/electron TEM; and a Helios NanoLab™ DualBeam™ focused ion
beam/scanning electron microscope (FIB/SEM) for sample preparation
and 3-D studies of cell structures. FEI's MAPS software enables
correlation between the electron microscope images and an image
from any other microscope within the facility.
Establishing the OHSU/FEI Living Lab has provided the OHSU and
FEI team with a forum to regularly share feedback on the
instrumentation as well as the experimentation. FEI and OHSU are
also establishing the first correlative workflow demonstration
showcase at the CLSB facility, which is jointly owned and operated
by OHSU, Oregon State University and Portland State University.
Using this workflow, researchers are able to start from live cell
imaging, continue to fixing cells and then go to high resolution
electron microscopy, all working from one software platform.
About OHSU
Oregon Health & Science University (http://www.ohsu.edu) is
a nationally prominent research university and Oregon's only public
academic health center. With 93 percent of its funding coming
from outside of Oregon, OHSU is counted among the nation's top 20
biomedical research institutions, according to the Blue Ridge
Institute for Medical Research. In 2013, OHSU announced 103
invention disclosures, 81 commercialization agreements and 98
industry collaboration agreements along with 452 material transfer
agreements with corporate researchers or researchers at other
nonprofit institutions. OHSU serves patients throughout the
Northwest with a Level 1 trauma center and nationally recognized
OHSU Doernbecher Children's Hospital. Its dental, medical, nursing
and pharmacy schools rank high both in research funding and in
meeting the university's social mission.
About FEI
FEI Company (Nasdaq:FEIC) designs, manufactures and supports a
broad range of high-performance microscopy workflow solutions that
provide images and answers at the micro-, nano- and picometer
scales. Its innovation and leadership enable customers in industry
and science to increase productivity and make breakthrough
discoveries. Headquartered in Hillsboro, Ore., USA, FEI has
over 2,600 employees and sales and service operations in more than
50 countries around the world. More information can be found at:
www.fei.com.
FEI Safe Harbor Statement
This news release contains forward-looking statements that
include statements regarding the performance capabilities and
benefits of the CorrSight system, Titan Krios TEM, Tecnai T12 TEM,
Tecnai with iCorr, Helios NanoLab DualBeam and MAPS software.
Factors that could affect these forward-looking statements include
but are not limited to our ability to manufacture, ship, deliver
and install the tools or software as expected; failure of the
product or technology to perform as expected; unexpected technology
problems and challenges; changes to the technology; the inability
of FEI, its suppliers or project partners to make the technological
advances required for the technology to achieve anticipated
results; and the inability of the customer to deploy the tools or
develop and deploy the expected new applications or workflows.
Please also refer to our Form 10-K, Forms 10-Q, Forms 8-K and other
filings with the U.S. Securities and Exchange Commission for
additional information on these factors and other factors that
could cause actual results to differ materially from the
forward-looking statements. FEI assumes no duty to update
forward-looking statements.
CONTACT: For more information contact:
Elisa Williams (media contact for OHSU)
+1 503 494 8231
willieli@ohsu.edu
Sandy Fewkes (media contact for FEI)
MindWrite Communications, Inc.
+1 408 224 4024
sandy@mind-write.com
FEI Company
Jason Willey (investors and analysts)
Investor Relations
+1 503 726 2533
Jason.willey@fei.com
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