Roche Reports Positive Late-Stage Trial Results for MS Drug
October 08 2015 - 1:57PM
Dow Jones News
By Ezequiel Minaya
Roche Holding AG on Thursday said its experimental treatment for
multiple sclerosis showed superiority to current drugs in two
late-stage trials involving patients with the most common form of
the disease.
The drug maker said the drug, known as ocrelizumab, also showed
efficacy in a third late-stage trial with patients who have a rarer
form of multiple sclerosis that has no approved treatments.
Roche said it plans to submit the results from the trials to the
U.S. Food and Drug Administration in early 2016, as it seeks
marketing approval to treat both forms of MS. The trials were
conducted by Roche's biotech business, Genentech.
Shares of Roche rose 2% to $33.19 in midday trading.
Multiple sclerosis is a chronic disease that affects an
estimated 2.3 million people around the world, according to the
company. Relapsing MS is the most common form of the disease, which
has no cure.
Two late-stage trials testing ocrelizumab in patients with
relapsing MS showed that ocrelizumab was better than Rebif, a
common therapy for relapsing MS, in reducing certain symptoms over
the course of the two-year test, Genentech said in a news
release.
In a separate study focusing on patients with a deteriorating
form of the illness, known as primary progressive multiple
sclerosis, the drug was said to reduce the progression of clinical
disability over 12- and 24-week periods when compared with a
placebo.
"Additionally, the study met other secondary endpoints of
reducing the time required to walk 25 feet, the volume of chronic
inflammatory brain lesions, and brain volume loss," the company
added.
Write to Ezequiel Minaya at ezequiel.minaya@wsj.com
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(END) Dow Jones Newswires
October 08, 2015 13:42 ET (17:42 GMT)
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