Pharmaceutical Safety Testing Open Letter
June 09 2011 - 5:00AM
RNS Non-Regulatory
TIDMCRX
Cyprotex PLC
09 June 2011
Cyprotex PLC
("Cyprotex" or the "Company" or the "Group")
Concerns About Pharmaceutical Safety Testing Cause Cyprotex to
Join in Signing an Open Letter to Prime Minister David Cameron and
Health Secretary Andrew Lansley
On behalf of Cyprotex PLC (AIM:CRX), Dr. Katya Tsaioun,
Cyprotex's Chief Scientific Officer, has joined with a group of
eminent UK clinicians and scientists who have written an open
letter (see
http://www.lancet.com/journals/lancet/article/PIIS0140-6736(11)60802-7/f
ulltext/ ) to Prime Minister David Cameron and Health Secretary
Andrew Lansley expressing concerns about the escalating problems of
drug failures and adverse drug reactions. Adverse drug reactions
have reached epidemic proportions amid rising costs in
prescriptions, with around 197,000 EU citizens dying every year
because of the problem.
The letter, published 3 June 2011 in the medical journal, The
Lancet, says the reliance on testing new drugs on animals before
humans is partly to blame, with trials on non-humans frequently
failing to translate to the clinic. The experts have called for the
use of more human-biology-based experiments where chemicals are
tested on human cells to see how people might be affected by new
treatments.
Following publication of the letter, Cyprotex's CEO, Dr. Tony
Baxter, was interviewed by Sky News (see
http://news.sky.com/skynews/Home/Politics/Scientists-Write-To-David-Came
ron-And-Andrew-Lansley-Over-Medicine-And-Drug-Failures/Article/201106116
004688 ) at Cyprotex's laboratory in Macclesfield.
Pointing at the crux of the problem, Dr. Baxter said, 'A
fundamental problem is that a rat is not a human. They are
different sizes, have different metabolisms, and have different
diets. So using animals to predict effects on humans is difficult.
Fifty percent of compounds that prove to be safe in rats prove not
to be safe in humans. So it really is the toss of a coin.'
Remarking on the issue, Dr Katya Tsaioun said, 'In the past few
years there has been tremendous progress in developing drug safety
tests based on human biology. Many of these models, such as
Cyprotex's CellCiphr(TM) assay for liver toxicity, are now superior
to animal testing. Yet, the pharmaceutical industry is hesitant to
adopt these tests because regulatory agencies have yet to adopt
them, which is in turn caused by the agencies' failure to
investigate them. The open letter addresses this by calling for the
UK Government to initiate a comparison of a set of
human-biology-based tests with those currently used, as proposed in
the Safety of Medicines Bill 2010-11, to see which are more
effective for predicting the safety of medicines for patients. 148
Members of Parliament have already signed a motion in support of
this proposal.
'Leading this initiative is the Safer Medicines Trust, an
independent patient safety organization and registered charity
(number 1039411). For more information see www.SaferMedicines.org
.'
For further information:
Cyprotex PLC
Tel: +44 (0) 1625 505 100
Dr Anthony Baxter, Chief Executive Officer
John Dootson, Chief Financial Officer
Mark Warburton, Chief Operating Officer and Legal Counsel
ir@cyprotex.com
www.cyprotex.com
Singer Capital Markets Limited (broker to Cyprotex)
Tel: +44 (0) 203 205 7500
Shaun Dobson
shaun.dobson@singercm.com
Claes Spang
claes.spang@singercm.com
www.singerscm.com
Financial Dynamics
Tel: +44 (0) 20 7831 3113
Ben Brewerton
Ben Atwell
Mo Noonan
cyprotex@fd.com
www.fd.com
Notes to Editors:
Cyprotex PLC
Cyprotex is the world's largest contract research organisation
(CRO) specialising in ADME Tox, which is the analysis of the
Absorption, Distribution, Metabolism, Excretion, and Toxicity
properties of potential drugs, cosmetics, and agrochemicals. It is
the only company in the world with in-house capabilities for both
in vitro (test tube) and in silico (computer modelling) ADME Tox.
Cyprotex was founded in 1999 and listed on the AIM in 2002. It has
laboratories in Macclesfield, Cheshire, UK (near Manchester), and
Watertown, Massachusetts, USA (near Boston), making it one of only
three ADME Tox CROs with international operations.
This information is provided by RNS
The company news service from the London Stock Exchange
END
NRASSUFMAFFSELM
Cyprotex (LSE:CRX)
Historical Stock Chart
From Mar 2024 to Apr 2024
Cyprotex (LSE:CRX)
Historical Stock Chart
From Apr 2023 to Apr 2024