FORM 4
[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

KIRK RANDAL J 		2. Issuer Name and Ticker or Trading Symbol

HALOZYME THERAPEUTICS INC [ HALO ] 		5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

__ X __ Director                      __ X __ 10% Owner
_____ Officer (give title below)      _____ Other (specify below)
(Last)          (First)          (Middle)

C/O THIRD SECURITY, LLC, 1881 GROVE AVENUE 		3. Date of Earliest Transaction (MM/DD/YYYY)

5/31/2016
(Street)

RADFORD, VA 24141
(City)        (State)        (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)

 
6. Individual or Joint/Group Filing (Check Applicable Line)

_ X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3) 		2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8) 		4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5) 		5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4) 		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock   5/31/2016     J (1)    1326320   (1) D   (1) 0   I   by NRM IV   (2)
Common Stock   5/31/2016     J (1)    81795   (1) A   (1) 216795   I   by Staff 2001   (2)
Common Stock   5/31/2016     J (1)    371186   (1) A   (1) 3056601   I   by R.J. Kirk DOT   (2)
Common Stock   5/31/2016     J (1)    372   (1) A   (1) 11317   I   by Lotus   (2)
Common Stock   5/31/2016     J (1)    9954   (1) A   (1) 302954   I   by JPK 2008   (2)
Common Stock   5/31/2016     J (1)    9954   (1) A   (1) 302954   I   by MGK 2008   (2)
Common Stock   5/31/2016     J (1)    9954   (1) A   (1) 302954   I   by ZSK 2008   (2)
Common Stock   5/31/2016     J (1)    23259   (1) A   (1) 354654   I   by JPK 2009   (2)
Common Stock   5/31/2016     J (1)    23259   (1) A   (1) 354653   I   by MGK 2009   (2)
Common Stock   5/31/2016     J (1)    2235   (1) A   (1) 2235   I   by ZSK 2009   (2)
Common Stock   5/31/2016     J (1)    27260   (1) A   (1) 290460   I   by JPK 2012   (2)
Common Stock   5/31/2016     J (1)    4382   (1) A   (1) 46701   I   by Kellie L. Banks LTT   (2)
Common Stock   5/31/2016     J (1)    131144   (1) A   (1) 131144   I   by Senior Staff 2006   (2)
Common Stock   5/31/2016     J (1)    65572   (1) A   (1) 65572   I   by Staff 2006   (2)
Common Stock   5/31/2016     J (1)    21858   (1) A   (1) 21858   I   by Incentive 2006   (2)
Common Stock                  3977445   I   by Kapital Joe   (2)
Common Stock                  6328853   I   by NRM V   (2)
Common Stock                  3538253   D    

Table II - Derivative Securities Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3) 		2. Conversion or Exercise Price of Derivative Security 3. Trans. Date 3A. Deemed Execution Date, if any 4. Trans. Code
(Instr. 8) 		5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5) 		6. Date Exercisable and Expiration Date 7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4) 		8. Price of Derivative Security
(Instr. 5) 		9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Explanation of Responses:
( 1)  On May 31, 2016, New River Management IV, LP ("NRM IV") made a liquidating distribution of its assets to its partners in connection with the dissolution of the partnership in accordance with the terms of its limited partnership agreement. NRM IV held 1,326,320 shares of common stock of the issuer. The following entities in their capacities as partners of NRM IV, or designees, received shares: Third Security Staff 2001 LLC ("Staff 2001"), R.J. Kirk DOT, Lotus Capital (2000) Co, Inc. ("Lotus"), JPK 2008 LLC ("JPK 2008"), MGK 2008 LLC ("MGK 2008"), ZSK 2008 LLC ("ZSK 2008"), JPK 2009 LLC ("JPK 2009"), MGK 2009 LLC ("MGK 2009"), ZSK 2009 LLC ("ZSK 2009"), JPK 2012 LLC ("JPK 2012"), Kellie L Banks (2009) Long Term Trust ("Kellie L. Banks LTT"), Third Security Senior Staff 2006 LLC ("Senior Staff 2006"), Third Security Staff 2006 LLC ("Staff 2006") and Third Security Incentive 2006 LLC ("Incentive 2006").
( 2)  Randal J. Kirk controls each of NRM IV, Staff 2001, R.J. Kirk DOT, Lotus, JPK 2008, MGK 2008, ZSK 2008, JPK 2009, MGK 2009, ZSK 2009, JPK 2012, Kellie L. Banks LTT, Senior Staff 2006, Staff 2006, Incentive 2006, Kapital Joe, LLC ("Kapital Joe") and New River Management V, LP ("NRM V"). Shares held by these entities may be deemed to be indirectly beneficially owned (as defined under Rule 13d-3 promulgated under the Securities Exchange Act of 1934, as amended) by Mr. Kirk. Mr. Kirk disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director 10% Owner Officer Other
KIRK RANDAL J
C/O THIRD SECURITY, LLC
1881 GROVE AVENUE
RADFORD, VA 24141 		X X


Signatures
/s/ Randal J. Kirk 6/2/2016
** Signature of Reporting Person Date


Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.
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