FORM 4
[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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OMB Number: 3235-0287
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

Alles Mark J 		2. Issuer Name and Ticker or Trading Symbol

CELGENE CORP /DE/ [ CELG ] 		5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director                      _____ 10% Owner
__ X __ Officer (give title below)      _____ Other (specify below)
See Remarks
(Last)          (First)          (Middle)

C/O CELGENE CORPORATION, 86 MORRIS AVENUE 		3. Date of Earliest Transaction (MM/DD/YYYY)

1/29/2016
(Street)

SUMMIT, NJ 07901
(City)        (State)        (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)

 
6. Individual or Joint/Group Filing (Check Applicable Line)

_ X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3) 		2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8) 		4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5) 		5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4) 		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
Common Stock   1/29/2016     M    2634   A $27.425   120381   D    
Common Stock   1/29/2016     M    4528   A $29.02   124909   D    
Common Stock   1/29/2016     M    2438   A $24.805   127347   D    
Common Stock   1/29/2016     M    1266   A $31.21   128613   D    
Common Stock   1/29/2016     M    2500   A $25.18   131113   D    
Common Stock   1/29/2016     M    1926   A $19.235   133039   D    
Common Stock   1/29/2016     M    2292   A $28.495   135331   D    
Common Stock   1/29/2016     M    1128   A $30.74   136459   D    
Common Stock   1/29/2016     M    1720   A $25.765   138179   D    
Common Stock   1/29/2016     M    1506   A $36.96   139685   D    
Common Stock                  5639   I   401(k) Plan  

Table II - Derivative Securities Beneficially Owned ( e.g. , puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3) 		2. Conversion or Exercise Price of Derivative Security 3. Trans. Date 3A. Deemed Execution Date, if any 4. Trans. Code
(Instr. 8) 		5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5) 		6. Date Exercisable and Expiration Date 7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4) 		8. Price of Derivative Security
(Instr. 5) 		9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4) 10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4) 11. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares
Stock Option (right to buy)   $27.425   1/29/2016     M         2634      (1) 1/9/2017   Common Stock   2634   $0.00   (2) 0   D    
Stock Option (right to buy)   $29.02   1/29/2016     M         4528      (1) 4/10/2017   Common Stock   4528   $0.00   (2) 0   D    
Stock Option (right to buy)   $24.805   1/29/2016     M         2438      (1) 1/8/2018   Common Stock   2438   $0.00   (2) 0   D    
Stock Option (right to buy)   $31.21   1/29/2016     M         1266      (1) 4/8/2018   Common Stock   1266   $0.00   (2) 0   D    
Stock Option (right to buy)   $25.18   1/29/2016     M         2500      (1) 1/13/2019   Common Stock   2500   $0.00   (2) 0   D    
Stock Option (right to buy)   $19.235   1/29/2016     M         1926      (1) 4/1/2019   Common Stock   1926   $0.00   (2) 0   D    
Stock Option (right to buy)   $28.495   1/29/2016     M         2292      (1) 1/12/2020   Common Stock   2292   $0.00   (2) 0   D    
Stock Option (right to buy)   $30.74   1/29/2016     M         1128      (1) 4/13/2020   Common Stock   1128   $0.00   (2) 0   D    
Stock Option (right to buy)   $25.765   1/29/2016     M         1720      (1) 1/31/2021   Common Stock   1720   $0.00   (2) 0   D    
Stock Option (right to buy)   $36.96   1/29/2016     M         1506      (1) 3/1/2022   Common Stock   1506   $0.00   (2) 2704   D    
Stock Option (right to buy)   $100.80   2/1/2016     A      8625         (3) 2/1/2026   Common Stock   8625   $0.00   (2) 8625   D    

Explanation of Responses:
( 1)  The option was fully exercisable.
( 2)  The option was issued pursuant to the Company's 2008 Stock Incentive Plan (as Amended and Restated as of April 15, 2015).
( 3)  Option is immediately exercisable and will vest in four equal annual installments commencing on February 1, 2017.

Remarks:
President and Chief Operating Officer

Reporting Owners
Reporting Owner Name / Address
Relationships
Director 10% Owner Officer Other
Alles Mark J
C/O CELGENE CORPORATION
86 MORRIS AVENUE
SUMMIT, NJ 07901

See Remarks

Signatures
/s/ Robert J. Hugin ______________________________________________________ Robert J. Hugin, Attorney-in-Fact 2/2/2016
** Signature of Reporting Person Date


Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.
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