Chartmaster
3 days ago
Therapeutic Solutions International Receives Notice of Allowance for Landmark Patent Covering Cellular Therapy of Lung Diseases
Clinical Stage Stem Cell Company Granted Exclusivity on the Use of Specific Immune System Cells to Increase Efficacy of Stem Cells in Lung Inflammation
ELK CITY, Idaho--(BUSINESS WIRE)-- Therapeutic Solutions International, Inc. (TSOI) announced today receipt of a Notice of Allowance from the United States Patent and Trademark Office regarding its patent application entitled “Stimulation of Mesenchymal Stem Cell Therapeutics Activities by Regulatory T Cells.”
The issued patent claims include:
“A method of inhibiting lung inflammation comprising: a) identifying a subject suffering from lung inflammation; b) administering a population of T regulatory cells in combination with a population of plastic adherent umbilical cord derived mesenchymal stem cells in an amount sufficient to reduce inflammation in said subject’s lungs.”
Therapeutic Solutions International owns a Phase III Investigational New Drug application for treatment of COVID-19. However, the Company is working on a new application for treating “all-cause” acute respiratory distress syndrome (ARDS) using the company’s patented JadiCell1, a true mesenchymal stem cell. Additionally, the Company has filed a Phase I/II clinical trial for COPD and possesses preclinical data for pulmonary fibrosis. All of these conditions are examples of lung inflammation.
“The claims issued today, in our opinion, capture the whole area of using a specific type of immune system cell, termed ‘T Regulatory Cells’ for enhancing activity of mesenchymal stem cells in all the major lung pathologies,” said Dr. Thomas Ichim, Board Member of TSOI and co-inventor of the patent. “We anticipate significant value in the current patent based on other companies working in the area of T regulatory cells. This is validated by the Regeneron-Sonoma Therapeutics2 and the Quell-AstraZeneca3 deals. It is nice to know that we own a potent piece of intellectual property that anyone hoping to enter this space will need to license.”
Dr. Ichim has a strong history of success in the area of biotechnology having taken his company Medistem from a 7 cent share price when he was made CEO to a sale at $1.35 to Intrexon, a NYSE traded company. Dr. Ichim’s lifetime of science, FDA clearances, and over 400 issued and published patents, have taken multiple companies to NASDAQ public listings.
“At Therapeutic Solutions International we are building a critical mass of clinical data, scientific discoveries, and patents4,” said Timothy Dixon, President, and CEO of the Company and co-inventor. “We believe we are developing significant traction which will result in partnerships and co-development deals.”
About Therapeutic Solutions International, Inc.
Therapeutic Solutions International is focused on immune modulation for the treatment of several specific diseases. The Company's corporate website is www.therapeuticsolutionsint.com.
1 https://patents.google.com/patent/US9803176B2/en?oq=9803176
2 https://www.fiercebiotech.com/biotech/sonoma-biotherapeutics-takes-big-bite-120m-regeneron-collab-tacking-five-new-targets
3 https://www.reuters.com/business/healthcare-pharmaceuticals/astrazeneca-signs-2-bln-agreement-with-quell-develop-cell-therapies-2023-06-09/
4 https://patents.justia.com/assignee/therapeutic-solutions-international-inc
https://cts.businesswire.com/ct/CT?id=bwnews&sty=20240516930973r1&sid=acqr8&distro=nx&lang=en
View source version on businesswire.com: https://www.businesswire.com/news/home/20240516930973/en/
Timothy G. Dixon
ir@tsoimail.com
Source: Therapeutic Solutions International, Inc.
© Copyright Business Wire 2024
https://www.otcmarkets.com/stock/TSOI/news/story?e&id=2863154
BigBadWolf
1 week ago
Trade Data since last T/A verified SS Update
Date Close/Last Volume Open High Low
05/09/2024 $0.0006 150,742,100 $0.0005 $0.0007 $0.0005
05/08/2024 $0.0006 170,815,400 $0.0007 $0.0007 $0.0005
05/07/2024 $0.0007 67,242,310 $0.0008 $0.001 $0.0007
05/06/2024 $0.0008 75,632,240 $0.0006 $0.0008 $0.0006
05/03/2024 $0.0006 57,890,520 $0.0005 $0.0006 $0.0005
05/02/2024 $0.0006 10,744,930 $0.0006 $0.0006 $0.0005
05/01/2024 $0.0006 17,697,640 $0.0005 $0.0006 $0.0005
04/30/2024 $0.0005 111,088,900 $0.0006 $0.0006 $0.0004
04/29/2024 $0.0006 48,979,020 $0.0007 $0.0007 $0.0005
04/26/2024 $0.0006 52,436,990 $0.0006 $0.0007 $0.0006
04/25/2024 $0.0006 22,166,110 $0.0006 $0.0006 $0.0005
04/24/2024 $0.0006 49,003,790 $0.0007 $0.0007 $0.0005
04/23/2024 $0.0006 25,939,830 $0.0007 $0.0007 $0.0006
04/22/2024 $0.0007 23,903,370 $0.0006 $0.0007 $0.0006
Authorized Shares 6,500,000,000 04/22/2024
Outstanding Shares 4,396,378,735 04/22/2024 >166,261,866
Restricted 1,454,564,260 04/22/2024 >57,857,142
Unrestricted 2,941,814,475 04/22/2024 >108,404,724
Held at DTC 2,839,780,106 04/22/2024 >56,818,182
T/A verifies Tim Dixon is responsible for the Ongoing pps decline
Authorized Shares 6,500,000,000 04/15/2024
Outstanding Shares 4,230,116,869 04/15/2024
Restricted 1,396,707,118 04/15/2024
Unrestricted 2,833,409,751 04/15/2024
Held at DTC 2,782,961,924 04/15/2024
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