By David Benoit and Jonathan D. Rockoff 

A sizable investor in Allergan Inc. doesn't favor the offer Valeant Pharmaceuticals International Inc. has made for the Botox maker, in conjunction with activist William Ackman.

Dan Davidowitz, the chief investment officer of Polen Capital Management LLC, said Thursday in an interview: "We think we could get this type of price just from another couple of years of compound earnings growth. So I don't think this is that attractive of an offer."

With about 0.9% of Allergan shares, Polen is a top 20 shareholder, according to FactSet. It has held the stock for about five years and counts it as its biggest position. Like all shareholders, he would benefit from an improved offer.

On Tuesday, Valeant unveiled a nearly $46 billion offer that valued Allergan shares at about $152.89 a share as of Monday's closing prices. Allergan had earlier resisted Valeant's private overtures.

Now, Valeant is on a campaign, with Mr. Ackman, to persuade Allergan shareholders to back its cash and stock bid. Analysts, investors and deal makers say a key question will be Allergan shareholders' appetite for Valeant shares. Valeant's stock has been a winner under its chief executive, Michael Pearson, who took over in 2008. But the strategies of the two drug makers are very different. Valeant shuns research and development and grows through product sales and acquisitions, while Allergan spends heavily on science.

In a research report in February, following a meeting with Allergan management, Sanford C. Bernstein & Co. analysts said shareholders would "hesitate" to take Valeant stock in a deal because they have "very different business models."

David Maris, a BMO Capital Markets analyst, said his conversations with many of the top 20 Allergan shareholders since news of the Valeant offer reveal concerns about taking on Valeant stock.

"There's a concern the currency -- Valeant stock -- is not worth dollar for dollar what they're getting. They'd rather have cash," Mr. Maris said.

Many leading Allergan shareholders are worried the Allergan business "will be worth less in a few years than it is now" because of Valeant's plans to cut spending on research and development and any changes it might make to marketing efforts.

Mr. Pearson said on Tuesday he expected stock of a combined company would cross $200 a share, and touted his company's ability to cut costs and grow a combined Allergan and Valeant. Mr. Ackman, whose firm now owns about 9.7% of Allergan, said he viewed his investment ultimately as a stake in Valeant. He called the campaign his first-ever pharmaceutical investment. "We think Valeant stock is cheap now," Mr. Ackman said.

Write to David Benoit at david.benoit@wsj.com and Jonathan D. Rockoff at jonathan.rockoff@wsj.com

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