By Kate Gibson, MarketWatch

NEW YORK (MarketWatch) -- U.S. stocks declined on Thursday, with the S&P 500 snapping its seven-session winning streak, as investors worried about developments related to Syria and Federal Reserve policy moves.

The Dow Jones Industrial Average (DJI) dropped 25.96 points, or 0.2%, to 15,300.64. J.P. Morgan Chase & Co. (JPM) fell 1.9%, making the bank the biggest decliner in the Dow.

Bolstering the blue-chip index, shares of Walt Disney Co. (DIS) rallied 2.4% after Bloomberg News reported the media conglomerate plans to repurchase between $6 billion and $8 billion in shares in the new year.

Halting its longest winning run since July, the S&P 500 (SPX) dropped 5.71 points, or 0.3%, to 1,683.42, with materials and financials posting the biggest losses among its 10 major industry groups.

In the materials sector, Cliffs Natural Resources Inc. (CLF) fell 5.2% after a downgrade from FBR, and Newmont Mining Corp. (NEM) shed 4.2% alongside falling metals prices.

Off the S&P 500, Barrick Gold Corp. (ABX) fell 5.5% as the price of gold tumbled. Gold futures for December delivery (GCZ3) slid $33.20, or 2.4%, to $1,330.60 an ounce, while crude-oil futures for October delivery (CLV3) added $1.04 to end at $108.60 a barrel.

Walgreen Co. (WAG) was the top gainer in the S&P 500, with shares of the drugstore chain rallying 5% after Goldman Sachs raised its rating on the stock to conviction buy from buy.

The Nasdaq Composite (RIXF) lost 9.04 points, or 0.2%, to 3,715.97.

More than 642 million shares traded on the New York Stock Exchange. Composite volume surpassed 3 billion shares.

Investors kept an eye on the conflict in Syria. U.S. Secretary of State John Kerry arrived in Geneva on Thursday for discussions with Russia's foreign minister on a proposed plan under which Syria will turn over its chemical weapons to the international community.

Separately, Syria's President Bashar al-Assad said the U.S. needs to give up "its policy of threats" and stop shipping arms to Syrian rebels before his government surrenders its chemical weapons, The Wall Street Journal reported. Read: Putin's op-ed gets chilly reception on Capitol Hill.

Wall Street's downside momentum picked up "as news came out that before 'signing on' Syria wants the U.S. to stop threatening them and to halt arms shipments to the rebels," wrote Elliot Spar, market strategist at Stifel, Nicolaus & Co., in afternoon commentary. "Oh yes, and we'll throw in a Mercedes S550 sedan as well," Spar quipped.

U.S. stock futures displayed little reaction on Thursday morning as data showed that jobless claims fell last week to their lowest level since April 2006, with the data skewed by computer upgrades in two states.

First-time claims for unemployment benefits declined by 31,000 to 292,000 in the week ending Sept. 7, but processing glitches involving two states clouded the reading, the Labor Department reported.

On Friday, several U.S. economic reports are due, including retail sales, producer prices and consumer sentiment.

In the bond market, the yield on the 10-year Treasury note (10_YEAR) fell 1 basis point to 2.908%. Many analysts believe the bond market has priced in reduced stimulus from the Federal Reserve, which could start tapering its asset purchases this month.

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